| Project/Area Number |
22659336
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIMURA Riko 大阪大学, 大学院・歯学研究科, 准教授 (60294112)
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| Co-Investigator(Renkei-kenkyūsha) |
YONEDA Toshiyuki 大阪大学, 大学院・歯学研究科, 教授 (80142313)
HATA Kenji 大阪大学, 大学院・歯学研究科, 講師 (80444496)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,410,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,200,000 (Direct Cost: ¥1,200,000)
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| Keywords | エピジェネティクス / 転写 / 未分化間葉系幹細胞 / 骨芽細胞 / 軟骨細胞 |
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| Research Abstract |
Mesenchymal stem cells(MSCs) have an unique ability to differentiate into several different cell linage including osteoblasts, chondrocytes, adipocytes and myocytes. In contrast, most of fibroblasts lack the ability. We focused on this difference between MSCs and fibroblasts, and examined differences of expression profiles and epigenetic information, in order to understand the molecules that are necessary for multipotent activity of MSCs. In addition, we attempted to approach the reprogramming of MSCs.
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