Role of Wnt-Ror2 signals in ruffled border formation in osteoclasts
Project/Area Number |
22659339
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Functional basic dentistry
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Research Institution | Matsumoto Dental University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Yasuhiro 松本歯科大学, 総合歯科医学研究所, 準教授 (20264252)
UEHARA Shunsuke 松本歯科大学, 歯学部, 助教 (90434480)
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Co-Investigator(Renkei-kenkyūsha) |
UDAGAWA Nobuyuki 松本歯科大, 歯学部, 教授 (70245801)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
Keywords | 口腔生化学 / 破骨細胞 / Wnt非古典経路 / 極性化 / 波上縁 / Wnt5a-Ror2シグナル / 低分子量Gタンパク質 / Wnt / Rho |
Research Abstract |
The role of Wnt5a-Ror2 signals in osteoclast function was studied. (1) Bone-resorbing activities of osteoclasts derived from Wnt5a-deficient mice and from Ror2 deficient mice were lower than that of wild-type(WT) osteoclasts. (2) Wnt5a activated Rho, a small G protein, in WT osteoclasts but not in Ror2-deficient osteoclasts. (3) When active Rho was transfected into Ror2-deficient osteoclasts, the bone-resorbing activity was recovered. Thus, Wnt5a-Ror2 signals play important roles in osteoclast function through a Rho-dependent mechanism.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Carbon nanotubes induce bone calcification by bidirectional interaction with osteoblasts2012
Author(s)
Shimizu M, Kobayashi Y, Mizoguchi T, Nakamura H, Kawahara I, Narita N, Usui Y, Aoki K, Hara K, Haniu H, Ogihara N, Ishigaki N, Nakamura K, Kato H, Kawakubo M, Dohi Y, Taruta S, Kim YA, Endo M, Ozawa H, Udagawa N, Takahashi N, Saito N
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Journal Title
Advanced Materials
Volume: 24
Issue: 16
Pages: 2176-2185
DOI
Related Report
Peer Reviewed
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[Journal Article] Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis2012
Author(s)
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
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Journal Title
Nat.Med.
Volume: (印刷中)
Issue: 3
Pages: 405-12
DOI
Related Report
Peer Reviewed
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[Journal Article] Lineage-Committed Osteoclast Precursors Circulate in Blood and Settle Down Into Bone2011
Author(s)
Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
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Journal Title
Journal of Bone and Mineral Research
Volume: 26
Issue: 12
Pages: 2978-2990
DOI
Related Report
Peer Reviewed
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[Journal Article] Polarized osteoclasts put marks of tartrate-resistant acid phosphatase on dentin slices-A simple method for identifying polarized osteoclasts-2011
Author(s)
Nakayama T, Mizoguchi T, Uehara S, Yamashita T, Kawahara I, Kobayashi Y, Moriyama Y, Kurihara S, Sahara N, Ozawa H, Udagawa N, Takahashi N
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Journal Title
Bone
Volume: 49(6)
Pages: 1331-1339
Related Report
Peer Reviewed
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[Journal Article] Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in CSF-1^<op/op> mice
Author(s)
Nakamichi Y, Mizoguchi T, Arai A, Kobayashi Y, Sato M, Penninger JM, Yasuda H, Kato S, DeLuca HF, Suda T, Udagawa N, Takahashi N
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Journal Title
Proc Natl Acad Sci UAS
Volume: (In press)
Related Report
Peer Reviewed
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