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Analysis of bone regeneration using small-molecule harmine and Id2-knockout mice

Research Project

Project/Area Number 22659356
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Dental engineering/Regenerative dentistry
Research InstitutionOsaka University

Principal Investigator

EGUSA Hiroshi  大阪大学, 大学院・歯学研究科, 助教 (30379078)

Co-Investigator(Kenkyū-buntansha) YATANI Hirofumi  大阪大学, 大学院・歯学研究科, 教授 (80174530)
SAEKI Makio  大阪大学, 大学院・歯学研究科, 講師 (30273692)
Co-Investigator(Renkei-kenkyūsha) YOKOTA Yoshifumi  福井大学, 医学部, 教授 (50222386)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,220,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
Keywords再生歯学 / harmine / Id2 / 骨芽細胞 / 破骨細胞 / ケミカルバイオロジー / id2 / 骨組織再生
Research Abstract

This research project was performed aiming at investigating new molecular mechanisms using Id2-knockout mouse-derived osteoclasts/ osteoblasts and small-molecules. We found that small-molecule harmine is a potent activator of NFATc1 due to its interference with the functions of the protein kinase DYRK1A in osteoclast progenitors, and via its induction of Id2 expression, thus leading to the disruption of the fusion events mediating osteoclastogenesis.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (9 results)

  • [Journal Article] The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells2011

    • Author(s)
      Egusa H, Doi M, Saeki M, Fukuyasu S, Akashi Y, Yokota Y, Yatani H, Kamisaki Y
    • Journal Title

      Bone

      Volume: 49(2) Pages: 264-274

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A small-molecule approach to bone regenerative medicine in dentistry2010

    • Author(s)
      Egusa H, Saeki M, Doi M, Fukuyasu S, Matsumoto T, Kamisaki Y, Yatani H
    • Journal Title

      Journal of Oral Biosciences

      Volume: 52(2) Pages: 107-118

    • NAID

      10027105562

    • URL

      http://ci.nii.ac.jp/naid/10027105562

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 骨芽細胞分化促進作用を有する小分子化合物の探索システムの構築2011

    • Author(s)
      福安翔, 江草宏, 佐伯万騎男, 矢谷博文
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨形成促進作用を有する小分子化合物の探索システムの構築2011

    • Author(s)
      福安翔, 江草宏, 萱島浩輝, 中野環, 矢谷博文
    • Organizer
      第41回日本口腔インプラント学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Id2欠損マウス由来iPS細胞を用いた骨芽細胞分化誘導モデル2011

    • Author(s)
      裏口真也, 江草宏, 萱島浩輝, 福安翔, 王放放, 矢谷博文
    • Organizer
      第9回日本再生歯科医学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨芽細胞分化促進作用を有する小分子化合物の探索システムの構築2011

    • Author(s)
      福安翔, 江草宏, 萱島浩輝, 裏口真也, 鎌野優弥, 矢谷博文
    • Organizer
      第9回日本再生歯科医学会学術大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 骨芽細胞分化促進作用を有する小分子化合物の探索システムの構築2011

    • Author(s)
      福安翔, 江草宏, 萱島浩輝, 裏口真也, 鎌野優弥, 佐伯万騎男, 矢谷博文
    • Organizer
      第112回大阪大学歯学会例会
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Cell-based double-screening method to identify reliable candidate for osteogenesis-targeting compounds2011

    • Author(s)
      Fukuyasu S, Egusa H, Akashi Y, Kayashima H, Uraguchi S, Yu G, Yatani H
    • Organizer
      89th IADR General Session
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2011-03-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Cell-based double-screening method to identify reliable candidate for osteogenesis-targeting compounds2011

    • Author(s)
      Fukuyasu S, Egusa H., et al.
    • Organizer
      89th国際歯科研究学会(IADR) General Session
    • Place of Presentation
      サンディエゴ(米国)
    • Year and Date
      2011-03-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dual function of small-molecule compound harmine on osteogenesis and osteoclastogenesis2010

    • Author(s)
      Fukuyasu S, Egusa H, Doi M, Kayashima H, Akashi Y, Yatani H
    • Organizer
      88th IADR General Session
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Dual function of small-molecule compound harmine on osteogenesis and osteoclas togenesis2010

    • Author(s)
      Fukuyasu S, Egusa H., et al.
    • Organizer
      88th国際歯科研究学会(IADR)General Session
    • Place of Presentation
      バルセロナ(スペイン)
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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