Targeting DDS with sensing function of tissular and environmental changes
Project/Area Number |
22659357
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Single-year Grants |
Research Field |
Dental engineering/Regenerative dentistry
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Research Institution | Okayama University |
Principal Investigator |
YOSHIDA Yasuhiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90281162)
|
Co-Investigator(Kenkyū-buntansha) |
OKIHARA Takumi 岡山大学, 大学院・自然科学研究科, 講師 (70243491)
NAGAOKA Noriyuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (70304326)
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
|
Keywords | DDS / ドラッグデリバリーシステム / キャリア / リン酸化糖 / 会合 / ミセル / 臨界 / CPC |
Research Abstract |
We synthesized phosphorylated polysaccharides as the carrier for bactericide delivery. It was indicated that 0. 01% phosphorylated pullulan and 0. 01% cetylpyridinium chloride(CPC) consistently exhibited an antibacterial effect, even after rinsing with distilled water, although CPC at a concentration of 10% showed no effect on bacterial growth after slight rinsing. Furthermore, phosphopullulan exhibited a controllable drug release property for antibacterial and anticancer agents.
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Report
(3 results)
Research Products
(34 results)
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[Journal Article] Effect of functional monomer and photo-initiator on the degree of conversion of a dental adhesive2012
Author(s)
Oguri, M., Yoshida, Y., Yoshihara, K., Miyauchi, T., Nakamura, Y., Shimoda, S., Hanabusa, M., Momoi, Y., Van Meerbeek, B
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Journal Title
Acta Biomaterialia
Volume: 8
Pages: 1928-1934
Related Report
Peer Reviewed
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[Journal Article] Real-time assessment of surface interactions with titanium passivation layer by surface plasmon resonance2012
Author(s)
Hirata, I., Yoshida, Y., Nagaoka, N., Hiasa, K., Abe, Y., Maekawa, K., Kuboki, T., Akagawa, Y., Suzuki, K., Van Meerbeek, B., Messersmith, P. B., Okazaki, M
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Journal Title
Acta Biomaterialia
Volume: 8
Pages: 1260-1266
NAID
Related Report
Peer Reviewed
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[Journal Article] Nano-layering of phosphoric-acid ester monomer at enamel and dentin2011
Author(s)
Yoshihara, K., Yoshida, Y., Hayakawa, S., Nagaoka, N., Irie, M., Ogawa, T., Van Landuyt K. L., Osaka, A., Suzuki, K., Minagi, S., Van Meerbeek, B
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Journal Title
Acta Biomaterialia
Volume: 7
Pages: 3187-3195
Related Report
Peer Reviewed
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[Journal Article] Sox9 expression during fracture repair2011
Author(s)
Shintaku, Y., Murakami, T., Yanagita, T., Kawanabe, N., Fukunaga, T., Matsuzaki, K., Matsuoka, S., Yoshida, Y., Kamioka, H., Takano-Yamamoto, T., Takada, K., Yamashiro, T
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Journal Title
Cells Tissues Organs
Volume: 194
Pages: 38-48
Related Report
Peer Reviewed
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[Journal Article] Detection of synthetic RGDS(PO_3H_2) PA peptide adsorption using a titanium surface plasmon resonance(SPR) biosensor2011
Author(s)
Abe, Y., Hiasa, K., Hirata, I., Okazaki, Y., Nogami, K., Mizumachi, W., Yoshida, Y., Suzuki, K., Okazaki, M., Akagawa, Y
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Journal Title
Journal of Materials Science : Materials in Medicine
Volume: 22
Pages: 657-661
Related Report
Peer Reviewed
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[Journal Article] Hydrolytic stability of one-step self-etch adhesives bonded to dentin2011
Author(s)
Fukuoka, A., Koshiro, K., Inoue, S., Yoshida, Y., Tanaka, T., Ikeda, T., Suzuki, K., Sano, H., Van Meerbeek, B
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Journal Title
Journal of Adhesive Dentistry
Volume: 13
Pages: 243-248
Related Report
Peer Reviewed
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[Journal Article] Self-etch monomer-calcium salt deposition on dentin2011
Author(s)
Yoshihara, K., Yoshida, Y., Hayakawa, S., Nagaoka, N., Torii, Y., Osaka, A., Suzuki, K., Minagi, S., Van Meerbeek, B., Van Landuyt K. L
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Journal Title
Journal of Dental Research
Volume: 90
Pages: 602-606
Related Report
Peer Reviewed
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[Journal Article] Effect of functional monomers in all-in-one adhesive systems on formation of enamel/dentin acid-base resistant zone2011
Author(s)
Nikaido, T., Ichikawa, C., Li, N., Takagaki, T., Sadr, A., Yoshida, Y., Suzuki, K., Tagami. J
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Journal Title
Dental Materials Journal
Volume: 30
Pages: 576-582
NAID
Related Report
Peer Reviewed
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[Journal Article] Enamel-smear compromises bonding by mild self-etch adhesives2010
Author(s)
Mine, A., De Munck, J., Vivan Cardoso, M., Van Landuyt, K. L., Poitevin, A., Kuboki, T., Yoshida, Y., Suzuki, K., Van Meerbeek, B
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Journal Title
Journal of Dental Research
Volume: 89
Pages: 1505-1509
Related Report
Peer Reviewed
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[Journal Article] Degree of immobilization of synthetic RGDS(PO_3H_2) PA peptides on titanium surfaces2010
Author(s)
Abe, Y., Okazaki, Y., Hiasa, K., Hirata, I., Yoshida, Y., Taji, T., Suzuki, K., Okazaki, M., Akagawa, Y
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Journal Title
Dental Materials Journal
Volume: 29
Pages: 668-672
NAID
Related Report
Peer Reviewed
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[Journal Article] The quasi-3D marginal leakage of full-coverage crowns : resin coating method versus sodium hypochlorite treatment2010
Author(s)
Kawahara, D., Mine, A., De Munck, J., Kuboki, T., Yoshida, Y., Suzuki, K., Van Meerbeek, B., Yatani, H
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Journal Title
The International Journal of Prosthodontics
Volume: 23
Pages: 406-409
Related Report
Peer Reviewed
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[Journal Article] Visible light-induced cross-linkable gelatin2010
Author(s)
Son, T. I., Sakuragi, M., Takahashi, S., Obuse, S., Kang, J. H., Fujishiro, M., Matsushita, H., Gong, J., Shimizu, S., Tajima, Y., Yoshida, Y., Suzuki, K., Yamamoto, T., Nakamura, M., Ito, Y
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Journal Title
Acta Biomaterialia
Volume: 6
Pages: 4005-4010
Related Report
Peer Reviewed
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[Journal Article] Nano-controlled molecular interaction at adhesive interfaces for hard-tissue reconstruction2010
Author(s)
Yoshihara, K., Yoshida, Y., Nagaoka, N., Fukegawa, D., Hayakawa, S., Mine, A., Nakamura, M., Minagi, S., Osaka, A., Suzuki, K., Van Meerbeek, B
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Journal Title
Acta Biomaterialia
Volume: 6
Pages: 3573-3582
Related Report
Peer Reviewed
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[Journal Article] TEM characterization of a silorane composite bonded to enamel/dentin2010
Author(s)
Mine, A., De Munck, J., Van Ende, A., Cardoso, M. V., Kuboki, T., Yoshida, Y., Van Meerbeek, B
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Journal Title
Dental Materials
Volume: 26
Pages: 524-532
Related Report
Peer Reviewed
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[Presentation] Phosphorylated Pullulan Bioadhesive for Hard-Tissue Reconstruction2010
Author(s)
Yoshida, Y., Takahata, T., Nakamura, M., Irie, M., Tanaka, M., Ozaki, T., Suzuki, K., Van Meerbeek, B
Organizer
88th General Session & Exhibition of the IADR
Place of Presentation
Barcelona, Spain
Related Report
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[Patent(Industrial Property Rights)] 生体硬組織接着用キット2011
Inventor(s)
吉田靖弘,田中雅人,鈴木一臣,尾崎敏文,高畑智宏,入江正郎,中村真理子,河島光伸,野尻大和,岡田浩一,長尾昌浩
Industrial Property Rights Holder
岡山大学,順正学園
Filing Date
2011-02-22
Related Report
Overseas
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