Targeting DDS with sensing function of tissular and environmental changes

• Project/Area Number: 22659357
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Okayama University
• Principal Investigator: YOSHIDA Yasuhiro 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90281162)
• Co-Investigator(Kenkyū-buntansha): OKIHARA Takumi 岡山大学, 大学院・自然科学研究科, 講師 (70243491) ; NAGAOKA Noriyuki 岡山大学, 大学院・医歯薬学総合研究科, 助教 (70304326)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
• Keywords: DDS / ドラッグデリバリーシステム / キャリア / リン酸化糖 / 会合 / ミセル / 臨界 / CPC

Research Abstract

We synthesized phosphorylated polysaccharides as the carrier for bactericide delivery. It was indicated that 0. 01% phosphorylated pullulan and 0. 01% cetylpyridinium chloride(CPC) consistently exhibited an antibacterial effect, even after rinsing with distilled water, although CPC at a concentration of 10% showed no effect on bacterial growth after slight rinsing. Furthermore, phosphopullulan exhibited a controllable drug release property for antibacterial and anticancer agents.

Research Products

• [Journal Article] Effect of functional monomer and photo-initiator on the degree of conversion of a dental adhesive (2012)
  • Author(s): Oguri, M., Yoshida, Y., Yoshihara, K., Miyauchi, T., Nakamura, Y., Shimoda, S., Hanabusa, M., Momoi, Y., Van Meerbeek, B
  • Journal Title: Acta Biomaterialia Volume: 8 Pages: 1928-1934
  • Peer Reviewed
• [Journal Article] Real-time assessment of surface interactions with titanium passivation layer by surface plasmon resonance (2012)
  • Author(s): Hirata, I., Yoshida, Y., Nagaoka, N., Hiasa, K., Abe, Y., Maekawa, K., Kuboki, T., Akagawa, Y., Suzuki, K., Van Meerbeek, B., Messersmith, P. B., Okazaki, M
  • Journal Title: Acta Biomaterialia Volume: 8 Pages: 1260-1266
  • NAID: 120005308253
  • Peer Reviewed
• [Journal Article] Nano-layering of phosphoric-acid ester monomer at enamel and dentin (2011)
  • Author(s): Yoshihara, K., Yoshida, Y., Hayakawa, S., Nagaoka, N., Irie, M., Ogawa, T., Van Landuyt K. L., Osaka, A., Suzuki, K., Minagi, S., Van Meerbeek, B
  • Journal Title: Acta Biomaterialia Volume: 7 Pages: 3187-3195
  • Peer Reviewed
• [Journal Article] Sox9 expression during fracture repair (2011)
  • Author(s): Shintaku, Y., Murakami, T., Yanagita, T., Kawanabe, N., Fukunaga, T., Matsuzaki, K., Matsuoka, S., Yoshida, Y., Kamioka, H., Takano-Yamamoto, T., Takada, K., Yamashiro, T
  • Journal Title: Cells Tissues Organs Volume: 194 Pages: 38-48
  • Peer Reviewed
• [Journal Article] Detection of synthetic RGDS(PO_3H_2) PA peptide adsorption using a titanium surface plasmon resonance(SPR) biosensor (2011)
  • Author(s): Abe, Y., Hiasa, K., Hirata, I., Okazaki, Y., Nogami, K., Mizumachi, W., Yoshida, Y., Suzuki, K., Okazaki, M., Akagawa, Y
  • Journal Title: Journal of Materials Science : Materials in Medicine Volume: 22 Pages: 657-661
  • Peer Reviewed
• [Journal Article] Hydrolytic stability of one-step self-etch adhesives bonded to dentin (2011)
  • Author(s): Fukuoka, A., Koshiro, K., Inoue, S., Yoshida, Y., Tanaka, T., Ikeda, T., Suzuki, K., Sano, H., Van Meerbeek, B
  • Journal Title: Journal of Adhesive Dentistry Volume: 13 Pages: 243-248
  • Peer Reviewed
• [Journal Article] Self-etch monomer-calcium salt deposition on dentin (2011)
  • Author(s): Yoshihara, K., Yoshida, Y., Hayakawa, S., Nagaoka, N., Torii, Y., Osaka, A., Suzuki, K., Minagi, S., Van Meerbeek, B., Van Landuyt K. L
  • Journal Title: Journal of Dental Research Volume: 90 Pages: 602-606
  • Peer Reviewed
• [Journal Article] Effect of functional monomers in all-in-one adhesive systems on formation of enamel/dentin acid-base resistant zone (2011)
  • Author(s): Nikaido, T., Ichikawa, C., Li, N., Takagaki, T., Sadr, A., Yoshida, Y., Suzuki, K., Tagami. J
  • Journal Title: Dental Materials Journal Volume: 30 Pages: 576-582
  • NAID: 10029480351
  • Peer Reviewed
• [Journal Article] Enamel-smear compromises bonding by mild self-etch adhesives (2010)
  • Author(s): Mine, A., De Munck, J., Vivan Cardoso, M., Van Landuyt, K. L., Poitevin, A., Kuboki, T., Yoshida, Y., Suzuki, K., Van Meerbeek, B
  • Journal Title: Journal of Dental Research Volume: 89 Pages: 1505-1509
  • Peer Reviewed
• [Journal Article] Degree of immobilization of synthetic RGDS(PO_3H_2) PA peptides on titanium surfaces (2010)
  • Author(s): Abe, Y., Okazaki, Y., Hiasa, K., Hirata, I., Yoshida, Y., Taji, T., Suzuki, K., Okazaki, M., Akagawa, Y
  • Journal Title: Dental Materials Journal Volume: 29 Pages: 668-672
  • NAID: 10026962580
  • Peer Reviewed
• [Journal Article] The quasi-3D marginal leakage of full-coverage crowns : resin coating method versus sodium hypochlorite treatment (2010)
  • Author(s): Kawahara, D., Mine, A., De Munck, J., Kuboki, T., Yoshida, Y., Suzuki, K., Van Meerbeek, B., Yatani, H
  • Journal Title: The International Journal of Prosthodontics Volume: 23 Pages: 406-409
  • Peer Reviewed
• [Journal Article] Visible light-induced cross-linkable gelatin (2010)
  • Author(s): Son, T. I., Sakuragi, M., Takahashi, S., Obuse, S., Kang, J. H., Fujishiro, M., Matsushita, H., Gong, J., Shimizu, S., Tajima, Y., Yoshida, Y., Suzuki, K., Yamamoto, T., Nakamura, M., Ito, Y
  • Journal Title: Acta Biomaterialia Volume: 6 Pages: 4005-4010
  • Peer Reviewed
• [Journal Article] Nano-controlled molecular interaction at adhesive interfaces for hard-tissue reconstruction (2010)
  • Author(s): Yoshihara, K., Yoshida, Y., Nagaoka, N., Fukegawa, D., Hayakawa, S., Mine, A., Nakamura, M., Minagi, S., Osaka, A., Suzuki, K., Van Meerbeek, B
  • Journal Title: Acta Biomaterialia Volume: 6 Pages: 3573-3582
  • Peer Reviewed
• [Journal Article] TEM characterization of a silorane composite bonded to enamel/dentin (2010)
  • Author(s): Mine, A., De Munck, J., Van Ende, A., Cardoso, M. V., Kuboki, T., Yoshida, Y., Van Meerbeek, B
  • Journal Title: Dental Materials Volume: 26 Pages: 524-532
  • Peer Reviewed
• [Presentation] 接着技術を活かした生体硬組織の再生・再建 (2012)
  • Author(s): 吉田靖弘
  • Organizer: 第50回臨床応用を目指した三次元臓器造形研究会
  • Place of Presentation: 東京大学医学部附属病院.東京
  • Year and Date: 2012-01-28
• [Presentation] 接着技術を活かした生体硬組織の再生・再建 (2012)
  • Author(s): 吉田靖弘
  • Organizer: 第50回臨床応用を目指した三次元臓器造形研究会
  • Place of Presentation: 東京大学医学部附属病院
  • Year and Date: 2012-01-28
• [Presentation] リン酸化プルランを用いた高機能医用材料の開発 (2011)
  • Author(s): 吉田靖弘
  • Organizer: 第90回岡山県医用工学研究会・メディカルテクノおかやま平成23年度第2回セミナー
  • Place of Presentation: 岡山
  • Year and Date: 2011-10-12
• [Presentation] リン酸化プルランを用いた高機能医用材料の開発 (2011)
  • Author(s): 吉田靖弘
  • Organizer: 第90回岡山県医用工学研究会・メディカルテクノおかやま平成23年度第2回セミナー
  • Place of Presentation: 岡山大学
  • Year and Date: 2011-10-12
• [Presentation] Phosphopullulan bioadhesive for hard-tissue reconstruction (2011)
  • Author(s): Yoshida, Y
  • Organizer: Start-up Symposium for Innovative Materials Research "A Roadmap for the Future of Oral Biomaterials"
  • Place of Presentation: Osaka, Japan
• [Presentation] 生体材料は高齢者の健康維持にどのように貢献できるか (2011)
  • Author(s): 吉田靖弘
  • Organizer: 日本老年歯科医学会第22回学術大会
  • Place of Presentation: 東京
• [Presentation] Phosphopullulan bioadhesive for hard-tissue reconstruction (2011)
  • Author(s): Yasuhiro Yoshida
  • Organizer: Start-up Symposium for Innovative Materials Research "A Roadmap for the Future of Oral Biomaterials"
  • Place of Presentation: Osaka University
• [Presentation] リン酸化プルランによる多目的医用材料の開発と製品化への検討 (2010)
  • Author(s): 吉田靖弘
  • Organizer: 両備椰園記念財団平成22年度第32回研究助成金贈呈式記念講演
  • Place of Presentation: 岡山
  • Year and Date: 2010-10-01
• [Presentation] 接着技術の応用による医用材料の高機能化 (2010)
  • Author(s): 吉田靖弘
  • Organizer: 日本歯科保存学2010年度会秋季学術大会(第133回)・第12回日韓歯科保存学会学術大会.シンポジウムII「機能性修復材料開発戦略のベクトルを探る」
  • Place of Presentation: 岐阜
• [Presentation] Phosphorylated Pullulan Bioadhesive for Hard-Tissue Reconstruction (2010)
  • Author(s): Yoshida, Y., Takahata, T., Nakamura, M., Irie, M., Tanaka, M., Ozaki, T., Suzuki, K., Van Meerbeek, B
  • Organizer: 88th General Session & Exhibition of the IADR
  • Place of Presentation: Barcelona, Spain
• [Presentation] 接着技術の応用による医用材料の高機能化 (2010)
  • Author(s): 吉田靖弘
  • Organizer: 日本歯科保存学2010年度会秋季学術大会(第133回)・第12回日韓歯科保存学会学術大会
  • Place of Presentation: 岐阜
• [Book] Basics in adhesion technology : In Caries management-Science and Clinical Practice (2011)
  • Author(s): Van Meerbeek, B., Yoshida, Y
• [Remarks] 吉田靖弘.(財)医科学応用研究財団平成23年調査研究助成金(2011年)
• [Remarks] 吉田靖弘.第54回日本歯科理工学会学術講演会発表優秀賞(2010年)
• [Remarks] 吉田靖弘.(財)ホクト生物科学振興財団平成22年度研究奨励金(2010年)
• [Remarks] 吉田靖弘.(財)両備.園記念財団平成22年度研究助成金(2010年)
• [Patent(Industrial Property Rights)] リン酸化多糖の製造方法 (2012)
  • Inventor(s): 沖原巧,亀ノ上翔吾,吉田靖弘,松川昭博,難波尚子,高柴正悟
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2012-073934
  • Filing Date: 2012-03-28
• [Patent(Industrial Property Rights)] リン酸化多糖の固相合成方法 (2012)
  • Inventor(s): 沖原巧,吉田靖弘,亀ノ上翔吾,井口勉,木島菜摘,難波尚子,長岡紀幸
  • Industrial Property Rights Holder: 岡山大学
  • Industrial Property Number: 2012-073933
  • Filing Date: 2012-03-28
• [Patent(Industrial Property Rights)] 生体硬組織接着用キット (2011)
  • Inventor(s): 吉田靖弘,田中雅人,鈴木一臣,尾崎敏文,高畑智宏,入江正郎,中村真理子,河島光伸,野尻大和,岡田浩一,長尾昌浩
  • Industrial Property Rights Holder: 岡山大学,順正学園
  • Filing Date: 2011-02-22
  • Overseas
• [Patent(Industrial Property Rights)] 虫歯予防剤 (2010)
  • Inventor(s): 吉田靖弘,高柴正悟,伊東孝,今村幸治,竹内英明,岡本英治
  • Industrial Property Rights Holder: 株式会社グライエンス,岡山大学
  • Industrial Property Number: 2010-105130
  • Filing Date: 2010-04-30