| Project/Area Number |
22659360
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
TOTSUKA Yasunori 北海道大学, 大学院・歯学研究科, 特任教授 (00109456)
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| Co-Investigator(Kenkyū-buntansha) |
SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
HIGASHINO Fumihiro 北海道大学, 大学院・歯学研究科, 准教授 (50301891)
HIDA Kyouko 北海道大学, 大学院・歯学研究科, 特任准教授 (40399952)
KITAMURA Tetsuya 北海道大学, 大学院・歯学研究科, 助教 (00451451)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,200,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 口腔外科学一般 / HuR / ARE-mRNA / AU-rich element / 転移・浸潤能 / ベルーカス病変 / 口腔がん |
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| Research Abstract |
I this study, we examined the localization of HuR in oral cancer cells, the cytoplasmic expression of HuR and malignancy, the relation between cytoplasmic HuR and precancerous change. HuR and AU-rich containing mRNA were exported to the cytoplasm of oral cancer cells. Cytoplasmic HuR expression increased in the cancer which had high malignancy and in the precancerous change which showed poor diagnosis. These findings suggest that the localization of HuR is available for diagnostic tool of precancerous change.
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