Energy metabolism and muscle pathology in denervated swallowing muscles
| Project/Area Number |
22659361
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Nobuo 北海道大学, 大学院・歯学研究科, 特任教授 (20091415)
YAMAZAKI Yutaka 北海道大学, 北海道大学病院, 講師 (90250464)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,230,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,800,000 (Direct Cost: ¥1,800,000)
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| Keywords | 筋線維タイプ / 咀嚼筋 / MRS / ATPase / 嚥下筋 / 筋繊維タイプ / 筋織維構成 / 順応 |
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| Research Abstract |
Swallowing mechanism are very complicated and muscle pathology of the swallowing muscles has yet to be clarified. Histochemical characteristics of the human masticatory muscles and swallowing muscles were investigated in this study. Experimental studies of soft diet and sympathectomy using young rabbits were also performed. Human masseter muscle and swallowing muscle showed unique histochemical characterstics reflecting highly differentiated masticatory and swallowing function. The soft diet experiment showed transformation of the muscle fiber types. Symathectomy experiment suggested that sympathetic nerve modulates differentiatin and metabolism of the muscle fibers.
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Report
(3 results)
Research Products
(10 results)
