| Project/Area Number |
22659363
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
MORI Shiro 東北大学, 病院, 講師 (80230069)
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| Co-Investigator(Renkei-kenkyūsha) |
KODAMA Tetsuya 東北大学, 医工学研究科, 教授 (40271986)
ONO Masao 東北大学, 医学系研究科, 教授 (20302218)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | FGFR2 / 疾患モデル / 関節強直症 / ナノバブル / 超音波 / 分子導入 / 生物製剤 / 遺伝子解析 / プラスミドDNA |
|---|
| Research Abstract |
The aim of the present study is to develop a study model and medical treatment procedure for the FGFR2-related craniosynostosis syndromes. In the present study, a new recombinant congenic strain of mice, which is a model for the dysplasia of bone and cartilage, was successfully established, and the onset of the disease in the mice was significantly associated with the genetic locus of FGFR2. By using the animal model and gene delivery system to the tissue around bone using nanobubbles and ultrasound, it became to be possible to perform an experimental molecular therapy using the Ig-Fc fusion protein of FGFR2 against the study model for the FGFR-related dysplasia of bone and cartilage.
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