| Project/Area Number |
22659364
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Chiba University |
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Principal Investigator |
TANZAWA Hideki 千葉大学, 大学院・医学研究院, 教授 (50236775)
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| Co-Investigator(Kenkyū-buntansha) |
OGAWARA Katsunori 千葉大学, 医学部附属病院, 講師 (20372360)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | microRNA / 口腔癌 / 放射線耐性 / ICAM遺伝子 / micro RNA |
|---|
| Research Abstract |
We previously reported that intercellular adhesion molecule 2 (ICAM2) gene is closely associated with radioresistant mechanism in oral squamous cell carcinoma (OSCC). And we identifind miR-125b potentially regulating ICAM2 gene expression. In this study, we evaluated the potential of targeting miRNA-125b for overcoming radio-resistance of OSCC with controled ICAM2-associated signaling. Significantly downregulated expression of miR-125b was revealed in OSCC-derived cell lines and OSCC samples when compared with human normal keratinocytes. Furthermore, miR-125b-transfected cells showed an enhanced radiosensitivity to X-ray irradiation, and diminished ICAM2 mRNA expression.
The data suggest that upregulated expression of miR-125b can induce an enhanced radiosensitivity via regulation of ICAM2 signalling.
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