| Project/Area Number |
22659367
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Surgical dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
SEO Kenji 新潟大学, 医歯学系, 教授 (40242440)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Takeyasu 新潟大学, 医歯学系, 教授 (40183941)
KITAGAWA Jyunichi 新潟大学, 医歯学系, 准教授 (50373006)
FUJIWARA Naoshi 新潟大学, 医歯学系, 教授 (70181419)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,220,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,400,000 (Direct Cost: ¥1,400,000)
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| Keywords | QX-314, リドカイン / ニューロパチー / TRPV1 / PAIN / 三叉神経 / QX-314 / カプサイシン / 末梢神経 / 知覚 / 神経因性疼痛 / 下歯槽神経 / 神経切断 / TRPV1チャネル / ラット / 触覚 / 三叉神経脊髄路核 / 侵害刺激 / 膜電位 / C-繊維 |
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| Research Abstract |
A novel local anesthetic, QX-314 is known to have an effect of Na+ channel blockade.This action requires it to enter through TRIPV1 channel on the surface of the neuron and make a blockade action inside the neuron. Thus, we aimed to study the possibility of QX-314 in anti-nociceptive effect and investigated the effects of QX-314 on the withdraw threshold which was decreased by a resection of inferior alveolar nerve in the rats. The results were that QX-314 using together with capsaicin, the threshold became to be elevated. This was consistent with histological findings that TRIPV1channels increased in the injured trigeminal nerve. These suggested that QX-314 has a potential to be used as a therapeutic tool for neuropathic pain.
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