Establishment of the dental pulp stem cell using a low molecular weight compound for tooth regeneration
| Project/Area Number |
22659373
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,320,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 歯髄幹細胞 / GSK3β特異的阻害剤 |
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| Research Abstract |
We found that BIO, a glycogen synthase kinase-3 (GSK3) inhibitor, induced changes in cell morphology, and promoted the expression of Nanog mRNA, considered the key gene to pluripotency, in mouse dental papilla derived mesenchymal (mDP) cells. When the BIO treated mDP cells were cultured in osteogenic differentiation medium, the expression of osteoblast maker genes and alkaline phosphatase activity were progressively increased.
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Report
(4 results)
Research Products
(30 results)
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[Journal Article] Role of epithelial-stem cell interactions during dental cell differentiation2012
Author(s)
Arakaki M, Ishikawa M, Nakamura T, Iwamoto T, Yamada A, Fukumoto E, Saito M, Otsu K, Harada H, Yamada Y, Fukumoto S
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Journal Title
J Biol Chem
Volume: 287(13)
Issue: 13
Pages: 10590-601
DOI
Related Report
Peer Reviewed
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