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Molecular dissection of membrane traffic machinery regulating preterm delivery induced by marginal periodontitis

Research Project

Project/Area Number 22659378
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Periodontal dentistry
Research InstitutionOsaka University

Principal Investigator

AMANO Atsuo  大阪大学, 大学院・歯学研究科, 教授 (50193024)

Co-Investigator(Kenkyū-buntansha) INABA Hiroaki  大阪大学, 大学院・歯学研究科, 助教 (70359850)
FURUTA Nobumichi  大阪大学, 大学院・歯学研究科, 助教 (50452446)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
Keywords歯学 / 感染症 / シグナル伝達 / 歯周病菌 / 細胞・組織 / トロフォブラスト / 早産 / 細菌
Research Abstract

Epidemiological and interventional studies of humans have revealed a close association between periodontal diseases and preterm delivery of low birth weight infants. Porphyromonas gingivalis, a periodontal pathogen, can translocate to gestational tissues following oral-hematogenous spread. We previously showed that P. gingivalis invades extravillous trophoblast cells(HTR-8) derived from the human placenta, and inhibits proliferation through induction of arrest in the G1 phase of the cell cycle. The purpose of the present study was to identify signaling pathways mediating cellular impairment caused by P. gingivalis. The obtained results results suggest that P. gingivalis gingivalis activates cellular DNA damage signaling pathways that lead to G1 arrest and apoptosis in trophoblasts.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (93 results)

All 2012 2011 2010 2009 Other

All Journal Article (49 results) (of which Peer Reviewed: 45 results) Presentation (33 results) Book (9 results) Remarks (2 results)

  • [Journal Article] Identification of signaling pathways mediating cell cycle arrest and apoptosis induced by Porphyromonas gingivalis in human trophoblasts2012

    • Author(s)
      Inaba H*, Kuboniwa M, Sugita H, Lamont RJ, Amano A
    • Journal Title

      Infect Immun

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex2012

    • Author(s)
      Kawai S*, Amano A
    • Journal Title

      J Cell Biol

      Volume: 197(2) Pages: 201-208

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guidelines for the use and interpretation of assays for monitoring autophagy2012

    • Author(s)
      Klionsky DJ*, Amano A, and 1268 others
    • Journal Title

      Autophagy

      Volume: 8(4) Pages: 1-100

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insights into the pathogenesis of dental plaque : discoveries from proteomics2012

    • Author(s)
      Kuboniwa M, Tribble GD, Hendrickson EL, Amano A, Lamont RJ, Hackett M
    • Journal Title

      Expert Review of Proteomics

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell entry and exit by periodontal pathogen Porphyromonas gingivalis2012

    • Author(s)
      Amano A*, Furuta N
    • Journal Title

      J Oral Biosci

      Volume: 54 Pages: 54-57

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 病因論から再考する歯周治療2012

    • Author(s)
      天野敦雄
    • Journal Title

      障害者歯科

      Volume: 32(1) Pages: 1-7

    • NAID

      10030299367

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Transition metal ions induce carnosinase activity in PepD-homologous protein from Porphyromonas gingivalis2012

    • Author(s)
      Aoki A, et al
    • Journal Title

      Microbial Pathogenesis

      Volume: 52 Pages: 17-24

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development and evaluation of new primers for PCR-based identification of type II fimA of Porphyromonas gingivalis2012

    • Author(s)
      Moon JH, et al
    • Journal Title

      FEMS Immunology & Medical Microbiology

      Volume: Nov 3(In press) Issue: 3 Pages: 425-428

    • DOI

      10.1111/j.1574-695x.2011.00889.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease2012

    • Author(s)
      Yoneda M, et al
    • Journal Title

      BMC Gastroenterology

      Volume: 12 Pages: 16-16

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex2012

    • Author(s)
      Kawai S, et al
    • Journal Title

      Journal of Cell Biology

      Volume: 192 Pages: 201-208

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insights into the pathogenesis of dental plaque : discoveries from proteomics2012

    • Author(s)
      Kuboniwa M, et al
    • Journal Title

      Expert Review

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 循環器疾患と歯周病2012

    • Author(s)
      天野敦雄, 他
    • Journal Title

      CLINICAL CALCIUM

      Volume: 22 Pages: 43-48

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Proliferation of smooth muscle cells stimulated with Porphyromonas gingivalis is inhibited by apple polyphenol2011

    • Author(s)
      Inaba H*, Tagashira M, Kanda T, Amano A
    • Journal Title

      J Periodontol

      Volume: 821(11) Pages: 1616-1622

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis2011

    • Author(s)
      Sugita A, Kawai S, Hayashibara T, Amano A, Ooshima T, Michigami T, Yoshikawa H, Yoneda T*
    • Journal Title

      J Biol Chem

      Volume: 286(4) Pages: 3094-3103

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway2011

    • Author(s)
      Takeuchi H, Furuta N, Morisaki I, Amano A*
    • Journal Title

      Cell Microbiol

      Volume: 13(5) Pages: 677-691

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The collagen-binding protein of Streptococcus mutans is involved in hemorrhagic stroke2011

    • Author(s)
      Nakano K, Hokamura K, Taniguchi N, Wada K*, Kudo C, Nomura R, Kojima A, Naka S, Muranaka Y, Thura M, Nakajima A, Masuda K, Nakagawa I, Speziale P, Shimada N, Amano A, Kamisaki Y, Tanaka T, Umemura K. Ooshima T
    • Journal Title

      Nature Commun

      Volume: 2 Pages: 485-485

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cell entry and exit by periodontal pathogen via recycling pathway2011

    • Author(s)
      Takeuchi H, Furuta N, Amano A*
    • Journal Title

      Commun Integr Biol

      Volume: 4(5) Pages: 587-589

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis2011

    • Author(s)
      Nakano K, et al
    • Journal Title

      Oral Diseases

      Volume: 17 Pages: 370-378

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis2011

    • Author(s)
      Sugita A, et al
    • Journal Title

      Journal of Biological Chemistry

      Volume: 286 Pages: 3094-3103

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exit of intracellular Porphyromonas gingivalis from gingival epithelial cells is mediated by endocytic recycling pathway2011

    • Author(s)
      Takeuchi H, et al
    • Journal Title

      Cellular Microbiology

      Volume: 13 Pages: 677-691

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The collagen-binding protein of Streptococcus mutans is involved in hemorrhagic stroke2011

    • Author(s)
      Nakano K, et al
    • Journal Title

      Nature Communications

      Volume: 2 Pages: 485-485

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Consideration on English education at Osaka University Graduate School of Dentistry2011

    • Author(s)
      Hamazaki Y, et al
    • Journal Title

      Journal of Osaka University Dental Society

      Volume: 56 Pages: 5-30

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Proliferation of smooth muscle cells stimulated with Porphyromonas gingivalis is inhibited by apple polyphenol2011

    • Author(s)
      Inaba H, et al
    • Journal Title

      Journal of Periodontology

      Volume: 82 Pages: 1616-1622

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell entry and exit by periodontal pathogen via recycling pathway2011

    • Author(s)
      Takeuchi H, et al
    • Journal Title

      Communicative & Integrative Biology

      Volume: 4 Pages: 587-589

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell entry and exit by periodontal pathogen Porphyromonas gingivalis2011

    • Author(s)
      Amano A, et al
    • Journal Title

      Journal of Oral Bioscience

      Volume: 54 Pages: 54-57

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 歯周病と4つの全身疾患2011

    • Author(s)
      天野敦雄, 他
    • Journal Title

      臨床薬理

      Volume: 42 Pages: 65-66

    • NAID

      10029432651

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Host-parasite interactions in periodontitis : Subgingival infection and host sensing2010

    • Author(s)
      Amano A*
    • Journal Title

      Periodontol 2000

      Volume: 52 Pages: 7-11

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial adhesins to host components in periodontitis2010

    • Author(s)
      Amano A*
    • Journal Title

      Periodontol 2000

      Volume: 52 Pages: 12-37

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Host membrane trafficking for conveyance of intracellular oral pathogens2010

    • Author(s)
      Amano A*, Furuta N, Tsuda K
    • Journal Title

      Periodontol 2000

      Volume: 52 Pages: 84-93

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mediatory molecules that fuse autophagosomes and lysosomes2010

    • Author(s)
      Furuta N, Yoshimori T, Amano A*
    • Journal Title

      Autophagy

      Volume: 6(3) Pages: 417-418

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of oral bacteria in cardiovascular diseases-From molecular mechanisms to clinical cases : Implication of periodontal diseases in development of systemic diseases2010

    • Author(s)
      Inaba H, Amano A*
    • Journal Title

      J Pharmacol Sci

      Volume: 113(2) Pages: 103-109

    • NAID

      10027745277

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Host-parasite interactions in periodontitis : Microbial pathogenicity and innate immunity2010

    • Author(s)
      Amano A*
    • Journal Title

      Periodontol 2000

      Volume: 54 Pages: 9-14

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genotyping to distinguish microbial pathogenicity in periodontitis2010

    • Author(s)
      Kuboniwa M, Inaba H, Amano A*
    • Journal Title

      Periodontol 2000

      Volume: 54 Pages: 136-159

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Outer membrane vesicles function as offensive weapons in host-parasite interactions2010

    • Author(s)
      Amano A*, Takeuchi H, Furuta N
    • Journal Title

      Microbe Infect

      Volume: 12(11) Pages: 791-798

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vtilb mediate the fusion of antibacterial and canonical autophagosomes with lysosomes2010

    • Author(s)
      Furuta N, Fujita N, Noda T, Yoshimori T, Amano A
    • Journal Title

      Molecular Biology of the Cell

      Volume: 21(6) Pages: 1001-1010

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular analysis of aortic intimal hyperplasia caused by Porphyromonas gingivalis infection in mice with endothelial damage2010

    • Author(s)
      Hokamura K, Inaba H, Nakano K, Nomura R, Yoshioka H, Taniguchi K, Ooshima T, Wada K, Amano A, Umemura K
    • Journal Title

      Journal of Periodontal Research

      Volume: 45(3) Pages: 337-344

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Odd-skipped related 2 is epigenetically regulated in cellular quiescence2010

    • Author(s)
      Kawai S, Amano A
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 396(4) Pages: 831-836

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Odd-skipped related 2 regulates genes related to proliferation and development2010

    • Author(s)
      Kawai S, Abiko Y, Amano A
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 398(2) Pages: 184-190

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis2010

    • Author(s)
      Nakano K, Wada K, Nomura R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T
    • Journal Title

      Oral Diseases

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular ATP synthesis mediated by type III sodium-dependent phosphate transporter Pit-1 is critical to chondrogenesis2010

    • Author(s)
      Sugita A, Kawai S, Hayashibara T, Amano A, Ooshima T, Michigami T, Yoshikawa H, Yoneda T
    • Journal Title

      Journal of Biological Chemistry

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Exit of intracellular Porphyromonas gingivalis from gingival epithelialcells is mediated by endocytic recycling pathway2010

    • Author(s)
      Takeuchi H, Furuta N, Morisaki I, Amano A
    • Journal Title

      Cellular Microbiology

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host-parasite interactions in periodontitis : Subgingival infection and host sensing2010

    • Author(s)
      Amano A
    • Journal Title

      Periodontology 2000

      Volume: 52 Pages: 7-11

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial adhesins to host components in periodontitis2010

    • Author(s)
      Amano A
    • Journal Title

      Periodontology 2000

      Volume: 52 Pages: 12-37

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host membrane trafficking for conveyance of intracellular oral pathogens2010

    • Author(s)
      Amano A, Furuta N, Tsuda K
    • Journal Title

      Periodontology 2000

      Volume: 52 Pages: 84-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of oral bacteria in cardiovascular diseases-From molecular mechanisms to clinical cases : Implication of periodontal diseases in development of systemic diseases2010

    • Author(s)
      Inaba H, Amano A
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 113(2) Pages: 103-109

    • NAID

      10027745277

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular machinery to fuse antimicrobial autophagosome with lysosome2010

    • Author(s)
      Furuta N, Amano A
    • Journal Title

      Communicative & Integrative Biology

      Volume: 3(4) Pages: 385-387

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Host-parasite interactions in periodontitis : Microbial pathogenicity and innate immunity2010

    • Author(s)
      Amano A
    • Journal Title

      Periodontology 2000

      Volume: 54 Pages: 9-14

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotyping to distinguish microbial pathogenicity in periodontitis2010

    • Author(s)
      Kuboniwa M, Inaba H, Amano A
    • Journal Title

      Periodontology 2000

      Volume: 54 Pages: 136-159

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Outer membrane vesicles function as offensive weapons in host-parasite interactions2010

    • Author(s)
      Amano A, Takeuchi H, Furuta N
    • Journal Title

      Microbes and Infection

      Volume: 12(11) Pages: 791-798

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Starategy of periodontal bacteria for periodontal destruction2012

    • Author(s)
      Amano A
    • Organizer
      The 2^<nd> International Joint Symposium on Oral and Dental Sciences-Featuring Next Generation of Regenerative Therapies in Dentistry-
    • Place of Presentation
      Yogjakarta, Indonesia
    • Year and Date
      2012-03-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Starategy of periodontal bacteria for periodontal destruction2012

    • Author(s)
      Amano A
    • Organizer
      The 2^<nd> International Joint Symposium on Oral and Dental Sciences
    • Place of Presentation
      Yogjakarta (Indonesia)(招待講演)
    • Year and Date
      2012-03-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 口腔領域の遺伝子診断「病因論から予測する歯周病発症リスク」2011

    • Author(s)
      天野敦雄
    • Organizer
      大阪府病院診療所歯科部長会・研修会
    • Place of Presentation
      大阪
    • Year and Date
      2011-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 口腔領域の遺伝子診断「病因論から予測する歯周病発症リスク」2011

    • Author(s)
      天野敦雄
    • Organizer
      大阪府病院診療所歯科部長会・研修会
    • Place of Presentation
      ホテルモントレー大阪(大阪市)(招待講演)
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 病因論から再考する歯周治療2011

    • Author(s)
      天野敦雄
    • Organizer
      障害者歯科学会教育講座、第28回日本障害者歯科学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-05
    • Related Report
      2011 Final Research Report
  • [Presentation] 病因論から再考する歯周治療2011

    • Author(s)
      天野敦雄
    • Organizer
      障害者歯科学会教育講座、第28回日本障害者歯科学会学術大会
    • Place of Presentation
      福岡国際会議場(福岡市)(招待講演)
    • Year and Date
      2011-11-05
    • Related Report
      2011 Annual Research Report
  • [Presentation] Outer membrane vesicles function as offensive weapons of Porphyromonas gingivalis2011

    • Author(s)
      Amano A
    • Organizer
      The Second Osaka Mahidol Chulalongkorn Joint Symposium
    • Place of Presentation
      Bangkok
    • Year and Date
      2011-10-25
    • Related Report
      2011 Final Research Report
  • [Presentation] Outer membrane vesicles function as offensive weapons of Porphyromonas gingivalis2011

    • Author(s)
      Amano A
    • Organizer
      The Second Osaka Mahidol Chulalongkorn Joint Symposium
    • Place of Presentation
      Bangkok (Thailand)(招待講演)
    • Year and Date
      2011-10-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Metabolome profiles in Porphyromonas gingivalis under erythritol stress2011

    • Author(s)
      Hashino E, Kuboniwa M, Amano A
    • Organizer
      JADR
    • Place of Presentation
      広島
    • Year and Date
      2011-10-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Multiple signalling pathways are involved in apoptosis and cell cycle arrest induced by periodontal pathogen in human trophoblast2011

    • Author(s)
      Inaba H, Kuboniwa M, Sugita H, Amano A
    • Organizer
      EMBO meetin
    • Place of Presentation
      Wien, Austria
    • Year and Date
      2011-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Outer membrane vesicles function as offensive weapons of Porphyromonas gingivalis2011

    • Author(s)
      Amano A
    • Organizer
      13rd International Congress of Bacteriology and Applied Microbiology
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Metabolome profiles in Streptococcus gordonii co-cultured with Porphyromonas gingivalis2011

    • Author(s)
      Kuboniwa M, Kuroda Y, Hashino E, Alghamdi S, Hackett M, Lamont RJ, Amano A
    • Organizer
      13rd International Congress of Bacteriology and Applied Microbiology
    • Place of Presentation
      Sapporo
    • Year and Date
      2011-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Outer membrane vesicles function as offensive weapons of Porphyromonas gingivalis2011

    • Author(s)
      Amano A
    • Organizer
      13rd International Congress of Bacteriology and Applied Microbiology
    • Place of Presentation
      札幌コンベンションセンター(札幌市)(招待講演)
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Strategy of periodontal bacteria for periodontal destruction2011

    • Author(s)
      Amano A
    • Organizer
      Periodontik Terkini, Universitas Gadjah Mada
    • Place of Presentation
      Yogjakarta, Indonesia
    • Year and Date
      2011-07-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Strategy of periodontal bacteria for periodontal destruction2011

    • Author(s)
      Amano A
    • Organizer
      Periodontik Terkini, Universitas Gadjah Mada
    • Place of Presentation
      ガジャマダ大学(Indonesia)(招待講演)
    • Year and Date
      2011-07-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] Metabolome profiles in Porphyromonas gingivalis stimulated with exogenous para-aminobenzoate2011

    • Author(s)
      Kuboniwa M, Alghamdi S, Hashino E, Lamont RJ, Amano A
    • Organizer
      7th International Conference of the Metabolomics Society
    • Place of Presentation
      Cairns, Australia
    • Year and Date
      2011-06-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 細菌感染症の転帰を決める細胞ロジスティクス機構の分子基盤解析2011

    • Author(s)
      天野敦雄、久保庭雅恵、古田信道
    • Organizer
      新学術領域「細胞内ロジスティクス」班会議
    • Place of Presentation
      鳥羽市
    • Year and Date
      2011-06-01
    • Related Report
      2011 Final Research Report
  • [Presentation] 細菌感染症の転帰を決める細胞ロジスティクス機構の分子基盤解析2011

    • Author(s)
      天野敦雄, 他
    • Organizer
      新学術領域「細胞内ロジスティクス」班会議
    • Place of Presentation
      鳥羽シーサイドホテル(鳥羽市)
    • Year and Date
      2011-06-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 歯周病菌と4つの全身疾患シンポジウム「ここまでわかった口腔細菌による全身疾患:最新の研究と臨床知見」2010

    • Author(s)
      天野敦雄、稲葉裕明
    • Organizer
      第31回日本臨床薬理学会年会
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯周病菌と4つの全身疾患シンポジウム「ここまでわかった口腔細菌による全身疾患:最新の研究と臨床知見」2010

    • Author(s)
      天野敦雄、稲葉裕明
    • Organizer
      第31回日本臨床薬理学会年会
    • Place of Presentation
      京都
    • Year and Date
      2010-12-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] Proteolytic action of P. gingivalis induces proliferation of vascular smooth muscle cells : A relationship with arteriosclerosis2010

    • Author(s)
      Inaba H, Amano A
    • Organizer
      9^<th> International Conference of Asian Academy of Preventive Dentistry
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2010-11-10
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 歯肉上皮細胞に侵入したPorphyromonas gingivalisの細胞外脱出経路の解析2010

    • Author(s)
      竹内洋輝、杉田孝之、森崎市治郎、天野敦雄
    • Organizer
      第27回日本障害者歯科学会学術大会
    • Place of Presentation
      東京
    • Year and Date
      2010-10-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] TGF-beta suppressed the expression of Odd-skipped related 2 in mesenchymal cells2010

    • Author(s)
      Kawai S, Amano A
    • Organizer
      32nd Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] fimA II型P.gingivalis (TDC60)新規治療標的分子の探索-PepD-2の機能について2010

    • Author(s)
      青木暁宣、柴田恭子、岡野総一郎、中川一路、天野敦雄、安孫子宜光
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 上皮細胞への細菌侵入とメンブレントラッフィクサテライトシンポジウム「歯学領域におけるメンブレントラフィック研究」2010

    • Author(s)
      天野敦雄、竹内洋輝、古田信道
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      江戸川区
    • Year and Date
      2010-09-20
    • Related Report
      2011 Final Research Report
  • [Presentation] 上皮細胞への細菌侵入とメンブレントラッフィクサテライトシンポジウム「歯学領域におけるメンブレントラフィック研究」2010

    • Author(s)
      天野敦雄、竹内洋輝、古田信道
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 歯肉上皮細胞に侵入したPorphyromonas gingivalisの細胞外脱出機構の解析2010

    • Author(s)
      竹内洋輝、古田信道、天野敦雄
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] 診療ユニット装着型歯科臨床シミュレーションシステムの開発2010

    • Author(s)
      長島正、三浦治郎、岩見行晃、木下可子、竹田佳奈、西郷真衣、山口哲、稲員洋顕、岡野道明、竹重文雄、天野敦雄、恵比須繁之
    • Organizer
      第29回日本歯科医学教育学会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] TGF-betaによるOdd-skipped related 2遣伝子の発現制御2010

    • Author(s)
      河合伸治、天野敦雄
    • Organizer
      第28回日本骨代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Systemic diseases and periodontal pathogen2010

    • Author(s)
      Amano A
    • Organizer
      Leeds & Osaka Universities International Symposium in Dentistry
    • Place of Presentation
      Leeds, England
    • Year and Date
      2010-07-05
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 細胞内ロジスティクス機構による細菌感染症の制御2010

    • Author(s)
      天野敦雄、竹内洋輝、古田信道
    • Organizer
      新学術領域「細胞内ロジスティクス」班会議
    • Place of Presentation
      札幌市
    • Year and Date
      2010-06-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞内ロジスティクス機構による細菌感染症の制御2010

    • Author(s)
      天野敦雄、竹内洋輝、古田信道
    • Organizer
      新学術領域「細胞内ロジスティクス」班会議
    • Place of Presentation
      札幌
    • Year and Date
      2010-06-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] ダウン症候群由来歯肉上皮細胞におけるLPS刺激によるIL-6およびIL-8の発現2009

    • Author(s)
      村上旬平、田中健司、堤香奈子、財間達也、天野敦雄、森崎市治郎
    • Organizer
      第26回日本障害者歯科学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-10-31
    • Related Report
      2010 Annual Research Report
  • [Book] 歯周病を科学する2012

    • Author(s)
      天野敦雄, 村上伸也, 岡賢二
    • Publisher
      クインテッセンス出版,東京
    • Related Report
      2011 Final Research Report
  • [Book] 歯周病を科学する2012

    • Author(s)
      天野敦雄, 他
    • Publisher
      クインテッセンス出版
    • Related Report
      2011 Annual Research Report
  • [Book] 「カラーアトラス口腔嫌気性グラム陰性桿菌[歯周病菌]」病原菌の今日的意味(4版松本慶蔵編)医薬ジャーナル2011

    • Author(s)
      天野敦雄, 中川一路, 浜田茂幸
    • Related Report
      2011 Final Research Report
  • [Book] 「口腔嫌気性グラム陰性桿菌:歯周病菌」病原菌の今日的意味(4版松本慶蔵編)医薬ジャーナル2011

    • Author(s)
      天野敦雄, 中川一路, 浜田茂幸
    • Related Report
      2011 Final Research Report
  • [Book] 病原菌の今日的意味2011

    • Author(s)
      天野敦雄, 他
    • Publisher
      医薬ジャーナル
    • Related Report
      2011 Annual Research Report
  • [Book] Periodontal disease : symptoms, treatment and prevention(In Yamamoto SL (ed.))(Periodontal diseases in children and adolescents-Clinical features and molecular biological findings-)2011

    • Author(s)
      Nakano K, Amano A, Ooshima T
    • Publisher
      Nova Science Publishers, Inc., NY, U.S.A(in press.)
    • Related Report
      2010 Annual Research Report
  • [Book] Molecular typing in bacterial infections(In Filipis I, McKee ML (ed.))(Genotyping of periodontal anaerobic bacteria in relationship to pathogenesis.)2011

    • Author(s)
      Kuboniwa M, Amano_A
    • Publisher
      Springer, NY, U.S.A.(in press.)
    • Related Report
      2010 Annual Research Report
  • [Book] 病原菌の今日的意味(4版 松本慶蔵編)(カラーアトラス 口腔嫌気性グラム陰性桿菌)2011

    • Author(s)
      天野敦雄、浜田茂幸
    • Publisher
      医薬ジャーナル,大阪(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] 病原菌の今日的意味(4版 松本慶蔵編)(口腔嫌気性グラム陰性桿菌:歯周病を惹起するプラーク細菌)2011

    • Author(s)
      天野敦雄、浜田茂幸
    • Publisher
      医薬ジャーナル,大阪(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://web.dent.osaka-u.ac.jp/~prevent/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.dent.osaka-u.ac.jp/~methodol/

    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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