| Project/Area Number |
22659378
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
AMANO Atsuo 大阪大学, 大学院・歯学研究科, 教授 (50193024)
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| Co-Investigator(Kenkyū-buntansha) |
INABA Hiroaki 大阪大学, 大学院・歯学研究科, 助教 (70359850)
FURUTA Nobumichi 大阪大学, 大学院・歯学研究科, 助教 (50452446)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,190,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 歯学 / 感染症 / シグナル伝達 / 歯周病菌 / 細胞・組織 / トロフォブラスト / 早産 / 細菌 |
|---|
| Research Abstract |
Epidemiological and interventional studies of humans have revealed a close association between periodontal diseases and preterm delivery of low birth weight infants. Porphyromonas gingivalis, a periodontal pathogen, can translocate to gestational tissues following oral-hematogenous spread. We previously showed that P. gingivalis invades extravillous trophoblast cells(HTR-8) derived from the human placenta, and inhibits proliferation through induction of arrest in the G1 phase of the cell cycle. The purpose of the present study was to identify signaling pathways mediating cellular impairment caused by P. gingivalis. The obtained results results suggest that P. gingivalis gingivalis activates cellular DNA damage signaling pathways that lead to G1 arrest and apoptosis in trophoblasts.
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