The oral immunological effect on bisphosphonate-treated mice model by periodontal disease associated-pathogen

• Project/Area Number: 22659383
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Social dentistry
• Research Institution: The University of Tokushima
• Principal Investigator: KATAOKA Kosuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (50283792)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,170,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: ビスフォスフォネート / 歯周病菌 / 粘膜免疫 / 顎骨壊死 / 骨免疫 / 破骨細胞 / サイトカイン / 顎骨壤死

Research Abstract

By using periodontal disease-associated pathogen-infected mice long-termed administered with bisphosphonate substrates, we showed long-term colonization of periodontal disease-associated bacterium and the accumulation of inflammatory cells in teeth extraction wound of the oral cavity. In addition, we displayed induction of osteoclasts differentiation-associated cytokines from CD4 T cells and MФof teeth extraction wound. Taken together, it was suggested that the existence of periodontal disease-associated bacterium had effect on the progress and outbreak of bisphosphonate-related Osteonecrosis of the Jaw.

Research Products

• [Journal Article] Novel vaccine development strategies for inducing mucosal immunity (2012)
  • Author(s): Fukuyama Y, Tokuhara D., Kataoka K., Gilbert R. S., McGhee J. R., Yuki Y., Kiyono H., Fujihashi K.
  • Journal Title: Expert Rev. Vaccines Volume: 11(3) Pages: 367-379
  • Peer Reviewed
• [Journal Article] Notch-ligand expression by NALT dendritic cells regulates mucosal Th-1 and Th-2 type responses (2012)
  • Author(s): Fukuyama Y., Tokuhara D., Sekine S., Kataoka K., Markham J. D., Irwin A. R., Moon G. H., Tokuhara Y., Fujihashi K., Davydova J., Yamamoto M., Gilbert R. S., and Fujihashi K.
  • Journal Title: Biochem. Bioph. Res. Co. Volume: 418(1) Pages: 6-11
  • Peer Reviewed
• [Journal Article] Oral-nasopharyngeal dendritic cells mediate T-independent IgA class switching on B-1 B cells (2011)
  • Author(s): Kataoka K., Fujihashi K., Terao Y., Gilbert R. S., Sekine S., Kobayashi R., Fukuyama Y., Kawabata S. and Fujihashi K.
  • Journal Title: PLoS ONE Volume: 6(9)
  • Peer Reviewed
• [Journal Article] Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination (2011)
  • Author(s): Baatarjav T., Kataoka K., Gilbert R. S., Terao Y., Fukui M., Goto M., Kawabata S., Yamamoto M., FujihashiK. and Ito H.-O.
  • Journal Title: Vaccine Volume: 29(34) Pages: 5747-5757
  • Peer Reviewed
• [Journal Article] Attenuation of respiratory immune responses by antiviral neuraminidase inhibitor treatment and boost of mucosal immunoglobulin A response by co-administration of immuno-modulator clarithromycin in paediatric influenza (2011)
  • Author(s): Kido H., Takahashi E., Kataoka K., Fujii M., Suzuki S., Iwase K., Ito C.
  • Journal Title: Influenza Other. Respi. Viruses Volume: 5 Pages: 240-242
  • Peer Reviewed
• [Journal Article] Nasal dendritic cell targeting flt3 ligand as a safe adjuvant elicits effective protection against fatal pneumococcul pneumoniae (2011)
  • Author(s): Kataoka K., Fujihashi K. Oma K., Fukuyama Y., Hollingshead S. K., Sekine S., Kawabata S., Ito H.-O., Briles D. E., Oishi K.
  • Journal Title: Infect. Immun. Volume: 79(7) Pages: 2819-2828
  • Peer Reviewed
• [Journal Article] Induction of IL-10-producing CD4+ T cells in chronic periodontitis (2011)
  • Author(s): Kobayashi R., Kono T., Bolerjeck B. A., Fukuyama Y., Gilbert R. S., Fujihashi K., Ruby J., Kataoka K., Wada M., Yamamoto M., Fujihashi K.
  • Journal Title: J. Dent. Res. Volume: 90(5) Pages: 653-658
  • Peer Reviewed
• [Journal Article] A combination of Flt3 ligand cDNA and CpG oligodeoxynucleotide as nasal adjuvant elicits protective secretory-IgA immunity to Streptococcus pneumoniae in aged mice (2011)
  • Author(s): Fukuyama Y., King J. D., Kataoka K., Kobayashi R., Gilbert R. S., Hollingshead S. K., Briles D. E., Fujihashi K.
  • Journal Title: J. Immunol. Volume: 184(4) Pages: 2454-2461
• [Journal Article] Induction of IL-10-producing CD4+ T cells in chronic periodontitis (2011)
  • Author(s): Kobayashi R., et al
  • Journal Title: Journal of Dental Research Volume: 90 Issue: 5 Pages: 653-658
  • DOI: 10.1177/0022034510397838
  • Peer Reviewed
• [Journal Article] Mucosal immune features to phosphorylcholine by nasal Flt3 ligand cDNA-based vaccination (2011)
  • Author(s): Baatarjav T., et al
  • Journal Title: Vaccine Volume: 29 Issue: 34 Pages: 5747-5767
  • DOI: 10.1016/j.vaccine.2011.05.097
  • Peer Reviewed
• [Journal Article] Oral-nasopharyngeal dendritic cells mediate T-independent IgA class switching on B-1 B cells (2011)
  • Author(s): Kataoka K., et al
  • Journal Title: PLoS ONE Volume: (In press) Issue: 9 Pages: e25396-e25396
  • DOI: 10.1371/journal.pone.0025396
  • Peer Reviewed
• [Journal Article] Levels of salivary stress markers in patients with anxiety about halitosis (2010)
  • Author(s): Fukui M., Hinode D., Yokoyama M., Yoshioka M., Kataoka K., Ito H.-O.
  • Journal Title: Arch. Oral Biol. Volume: 55(11) Pages: 842-847
  • Peer Reviewed
• [Journal Article] Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae (2010)
  • Author(s): Fukuyama Y., King J. D., Kataoka K., Kobayashi R., Gilbert R. S., Oishi K., Hollingshead S. K., Briles D. E., Fujihashi K.
  • Journal Title: J. Immunol. Volume: 185(3) Pages: 1755-1762
  • Peer Reviewed
• [Journal Article] Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus (2010)
  • Author(s): Takahashi E., Kataoka K., Fujii K., Chida J., Mizuno D., Fukui M., Ito H.-O., Fujihashi K., Kido H.
  • Journal Title: Microbes. Infect. Volume: 12(10) Pages: 778-783
  • Peer Reviewed
• [Journal Article] Fusobacterium nucleatum envelope protein FomA is immunogenic and binds to salivary statherin-derived peptide (2010)
  • Author(s): Nakagaki H., Sekine S., Terao Y., Toe M., Tanaka M., Ito H., Kawabata S., Shizukuishi S., Fujihashi K., Kataoka K.
  • Journal Title: Infect. Immun. Volume: 78(3) Pages: 1185-1192
  • Peer Reviewed
• [Journal Article] Fusobacterium nucleatum envelope protein FomA is immunogenic and binds to salivary statherin-derived peptide. (2010)
  • Author(s): Nakagaki H., et al.
  • Journal Title: Infection and Immunity Volume: 78 Pages: 1185-1192
  • Peer Reviewed
• [Journal Article] Attenuation of inducible respiratory immune responses by oselta-mivir treatment in mice infected with influenza A virus. (2010)
  • Author(s): Takahashi E., et al.
  • Journal Title: Microbes and Infection Volume: 12 Pages: 778-783
  • Peer Reviewed
• [Journal Article] Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae. (2010)
  • Author(s): Fukuyama Y., et al.
  • Journal Title: Journal of Immunology Volume: 185 Pages: 1755-1762
  • Peer Reviewed
• [Presentation] ヒト唾液中および血中の抗ホスホリルコリン抗体と動脈硬化リスクとの関連性:五島研究 (2011)
  • Author(s): 福井誠
  • Organizer: 第60回口腔衛生学会総会
  • Place of Presentation: 日本大学松戸歯学部(松戸市)
  • Year and Date: 2011-10-10
• [Presentation] 経鼻粘膜アジュバントCpG ODNはマクロファージのTLR9発現と歯周病原細菌抗原特異的Th1免疫応答を誘導する (2011)
  • Author(s): サプタ・ムルヤトノ
  • Organizer: 第60回口腔衛生学会総会
  • Place of Presentation: 日本大学松戸歯学部(松戸市)
  • Year and Date: 2011-10-09
• [Presentation] 佐用町台風第9号災害における住民の口腔保健調査 (2011)
  • Author(s): 関根伸一
  • Organizer: 第59回口腔衛生学会総会
  • Place of Presentation: 朱鷺メッセ(新潟市)
  • Year and Date: 2011-10-08
• [Presentation] 平成22年度に香川県内で実施された成人歯科健診モデル事業報告 (2011)
  • Author(s): 渋谷敦人
  • Organizer: 第22回近畿・中国・四国口腔衛生学会総会
  • Place of Presentation: 徳島大学(徳島市)
  • Year and Date: 2011-10-02
• [Presentation] 妊婦歯科健康診査受診者の妊娠中の歯周状態と出産の状況について (2011)
  • Author(s): 武川香織
  • Organizer: 第22回近畿・中国・四国口腔衛生学会総会
  • Place of Presentation: 徳島大学(徳島市)
  • Year and Date: 2011-10-02
• [Presentation] Nasal dendritic cell targeting Flt3 ligand as a safe adjuvant elicits effective protection against fatal pneumococcal pneumonia (2011)
  • Author(s): 片岡宏介
  • Organizer: 15^<th> International Congress of Mucosal Immunology
  • Place of Presentation: フランス第5大学(フランス)
  • Year and Date: 2011-07-09
• [Presentation] Nasal dendritic cell targeting Flt3 ligand as a safe adjuvant elicits effective protection against fatal pneumococcal pneumonia (2011)
  • Author(s): Kataoka, K
  • Organizer: 15^<th> International Congress of Mucosal Immunology
  • Place of Presentation: Paris, France
  • Year and Date: 2011-07-08
• [Presentation] Cytokine profile in human saliva and its relationship with that in blood (2010)
  • Author(s): Mulyatno A. S.
  • Organizer: International Joint QOL Symposium on Oral Science
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2010-12-18
• [Presentation] Cytokine profile in human saliva and its relationship with that in blood (2010)
  • Author(s): Fukui M.
  • Organizer: 9^<th> International Conference Asian Academy of Preventive Dentistry
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2010-11-10
• [Presentation] 遺伝子改変植物による歯周病原菌定着阻害能を有するヒト唾液タンパク質スタセリンペプチドの発現 (2010)
  • Author(s): 片岡宏介
  • Organizer: 第59回口腔衛生学会総会
  • Place of Presentation: 朱鷺メッセ(新潟市)
  • Year and Date: 2010-10-08
• [Presentation] ヒト血中および唾液中の抗ホスホリルコリン抗体の存在実態 (2010)
  • Author(s): 福井誠
  • Organizer: 第59回口腔衛生学会総会
  • Place of Presentation: 朱鷺メッセ(新潟市)
  • Year and Date: 2010-10-08
• [Presentation] Nasal Flt3L gene results in mucosal immune responses to PC through induction of B-1 B cells (2010)
  • Author(s): Baatarjav T.
  • Organizer: 第59回口腔衛生学会総会
  • Place of Presentation: 朱鷺メッセ、(新潟市)
  • Year and Date: 2010-10-08
• [Presentation] 受動免疫型および能動免疫型ワクチン開発への挑戦~粘膜免疫学と分子生物学を基盤とした予防歯科学的展開 (2010)
  • Author(s): 片岡宏介
  • Organizer: 第59回口腔衛生学会総会シンポジウム「口腔の健康を科学する」
  • Place of Presentation: 朱鷺メッセ(新潟市)
  • Year and Date: 2010-10-07
• [Presentation] Flt3 ligand cDNA及びCpG ODNは粘膜アジュバントとしてP. gingivalis抗原特異的抗体反応を誘導する (2010)
  • Author(s): 関根伸一
  • Organizer: 第53回日本歯周病学会秋季学術大会
  • Place of Presentation: サンポート高松(高松市)
  • Year and Date: 2010-09-19
• [Presentation] 粘膜アジュバントCpGオリゴヌクレオチドによるPorphyromonas gingivalis線毛抗原特異的抗体応答の誘導 (2010)
  • Author(s): 片岡宏介
  • Organizer: 第53回日本歯周病学会秋季学術大会
  • Place of Presentation: サンポート高松(高松市)
  • Year and Date: 2010-09-19
• [Presentation] Nasal Cholera Toxin Activated Mucosal Densritic Cells, but not CD4^+ Cells Elicits TI-IgA Class Switching Recombination by B-1 B Cells (2010)
  • Author(s): Kataoka K.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-27
• [Presentation] Nasal Cholera Toxin Activated Mucosal Densritic Cells, but not CD4^+ Cells Elicits TI-IgA Class Switching Recombination by B-1 B Cells. (2010)
  • Author(s): 片岡宏介
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際展示場(兵庫県)
  • Year and Date: 2010-08-24
• [Presentation] Nasal Vaccination with Phosphorylcholine plus Flt3 Ligand Gene as a Mucosal Adjuvant Inhibits Streptococcus pneumoniae Colonization (2010)
  • Author(s): Baatarjav T.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] Characterization of Mucosal Immunosenescence in Nasopharyngeal-Associated Lymphoreticular Tissue (2010)
  • Author(s): Sekine S.
  • Organizer: 14^<th> International Congress of Immunology
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2010-08-23
• [Presentation] ヒト唾液タンパク質由来ペプチドの歯周病菌定着阻害効果 (2010)
  • Author(s): 片岡宏介
  • Organizer: 第21回近畿・中国・四国口腔衛生学会総会
  • Place of Presentation: サンラポーむらくも(松江市)
  • Year and Date: 2010-06-20
• [Presentation] ヒトの唾液中および血中に存在する抗ホスホリルコリン抗体の検出 (2010)
  • Author(s): 福井誠
  • Organizer: 第21回近畿・中国・四国口腔衛生学会総会
  • Place of Presentation: サンラポーむらくも(松江市)
  • Year and Date: 2010-06-20
• [Presentation] 平成21年度に香川県内で実施された成人歯科健診モデル事業実施報告 (2010)
  • Author(s): 三崎昌和
  • Organizer: 第21回近畿・中国・四国口腔衛生学会総会
  • Place of Presentation: サンラポーむらくも(松江市)
  • Year and Date: 2010-06-20
• [Presentation] Fusobacterium nucleatum表層タンパク質FomAと唾液高チロシンタンパク質スタセリンペプチドとの相互作用 (2010)
  • Author(s): 片岡宏介
  • Organizer: 第53回日本歯周病学会春季学術大会
  • Place of Presentation: 盛岡市
  • Year and Date: 2010-05-15