| Project/Area Number |
22659383
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Social dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KATAOKA Kosuke 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (50283792)
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|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,170,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,000,000 (Direct Cost: ¥2,000,000)
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| Keywords | ビスフォスフォネート / 歯周病菌 / 粘膜免疫 / 顎骨壊死 / 骨免疫 / 破骨細胞 / サイトカイン / 顎骨壤死 |
|---|
| Research Abstract |
By using periodontal disease-associated pathogen-infected mice long-termed administered with bisphosphonate substrates, we showed long-term colonization of periodontal disease-associated bacterium and the accumulation of inflammatory cells in teeth extraction wound of the oral cavity. In addition, we displayed induction of osteoclasts differentiation-associated cytokines from CD4 T cells and MФof teeth extraction wound. Taken together, it was suggested that the existence of periodontal disease-associated bacterium had effect on the progress and outbreak of bisphosphonate-related Osteonecrosis of the Jaw.
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