Analysis of frequency specificity, oscillations and adaptation in a signaling pathway consisting of multiple signaling modules.
| Project/Area Number |
22680024
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SAWAI Satoshi 東京大学, 大学院・総合文化研究科, 准教授 (20500367)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2012: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 生体情報 / 振動 / 適応 / 粘菌 / 入出力関係 / 頑強性 / モジュール / シグナル伝達 / ネットワーク / ライブセルイメージング / 自己組織化 |
|---|
| Research Abstract |
Adaptive and oscillatory response consisting of multiple time-scales was analyzed by taking an example from cAMP-induced cAMP relay-response in Dictyostelium. Based on quantitative live-cell imaging analysis, we found that the first peak can be considered as an output from a module that realizes fold-change detection. The prolonged response on the other hand depends on the absolute concentration of extracellular cAMP and appears to be dependent on F-actin mediated feedaback. We discussed the relationship between these observed properties and robustness of cell-cell signaling.
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Report
(4 results)
Research Products
(99 results)
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[Presentation] 自己組織化する集合シグナルと協調的な細胞運動2011
Author(s)
中島昭彦, 廣瀬滋規, 谷口大相, Gad Shaulsky, Adam Kuspa, 澤井哲
Organizer
第11回東京大学生命科学シンポジウム
Place of Presentation
東京大学本郷キャンパス(ポスター発表)
Year and Date
2011-06-04
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