Chromatin regulation and nuclear architecture during activity-dependent transcription in post-mitotic neurons
| Project/Area Number |
22680027
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neuroscience in general
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| Research Institution | Gunma University (2011-2012)
Nara Institute of Science and Technology (2010) |
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Principal Investigator |
TAKIZAWA Takumi 群馬大学, 大学院・医学系研究科, 准教授 (30531115)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
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| Keywords | 分子・細胞神経科学 / 細胞核構造 / ニューロン / クロマチン / 転写 / 神経活動依存性転写 / 核構造 / エピジェネティクス |
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| Research Abstract |
We have studied the transcriptional regulation of activity dependent genes from the aspects of chromatin dynamics and spatial gene positioning. We have revealed, in this study, that temporal regulation of activity dependent genes is associated with their spatial positioning. We also found that chromatin-related proteins occupying activity-dependent genes dynamically change their behavior in a neuronal activity dependent manner.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Role of GLI2 in the growth of human osteosarcoma2011
Author(s)
Nagao, H., Ijiri, K., Hirotsu, M., Ishidou, Y., Yamamoto, T., Nagano, S., Takizawa, T., Nakashima, K., Komiya, S. & Setoguchi, T.
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Journal Title
J athol
Volume: 224
Pages: 169-179
Related Report
Peer Reviewed
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