|Budget Amount *help
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2013: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2012: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2011: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2010: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
|Outline of Final Research Achievements
Olfactory adaptation is classified into two classes; the peripheral adaptation and the central adaptation. We analyzed the latter type of adaptation, neural circuit-dependent adaptation, in C.elegans. In this study, we identified neurons underlying the adaptation and found these neurons change their responses to odor stimuli when the adaptation occurs. We established the in vivo imaging system to observe the activity of Ras, which plays major roles in this adaptation, and revealed quick activation and inactivation of Ras and regulatory mechanisms of them. In addition, to understand the mechanism of input of odorant stimuli, we comprehensively identified olfactory receptors for specific odorants and demonstrated different receptors respond to the same odorant when odor concentrations are different.