| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2010: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Research Abstract |
Axon initial segment (AIS) is the most critical site to determine the neural activity. In this project, I examined the properties of plasticity of AIS in avian brainstem auditory neurons and found that the deprivation of auditory inputs rearranges the AIS to increase its length, leading to augment the excitability of the neuron. This plasticity at the spike initiation site should be a most efficient mechanism to regulate the neural activity, and may play a critical role in the maintenance of auditory pathway after hearing loss.
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