Plasticity at the axon initial segment in auditory neurons
| Project/Area Number |
22680032
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Nagoya University (2011-2012)
Kyoto University (2010) |
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Principal Investigator |
KUBA Hiroshi 名古屋大学, 医学系研究科, 教授 (10362469)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2012: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2010: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Keywords | ニューロン / シナプス / 神経回路 / 神経科学 / 生理学 / 聴覚 / 活動電位 / チャネル / 軸索 |
|---|
| Research Abstract |
Axon initial segment (AIS) is the most critical site to determine the neural activity. In this project, I examined the properties of plasticity of AIS in avian brainstem auditory neurons and found that the deprivation of auditory inputs rearranges the AIS to increase its length, leading to augment the excitability of the neuron. This plasticity at the spike initiation site should be a most efficient mechanism to regulate the neural activity, and may play a critical role in the maintenance of auditory pathway after hearing loss.
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Report
(4 results)
Research Products
(31 results)
