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Design of biomaterials based on the analysis of hydration dynamics around polyelectrolytes

Research Project

Project/Area Number 22680039
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionTohoku University

Principal Investigator

MORIMOTO Nobuyuki  東北大学, 大学院・工学研究科, 准教授 (00313263)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Keywords水和 / 高分子電解質 / 誘電緩和分光測定 / ナノキャリア / 蛍光異方性 / 高分子構造・物性 / 生体材料 / バイオテクノロジー
Research Abstract

Dynamic hydration structures around charged molecules and polymers were evaluated by measurements of dielectric relaxation spectroscopy and the mathematical analysis. By accurate control of temperature, we could confirm water around the solutes with the higher relaxation frequency than that of bulk water. The existence of the water was depended on functional groups, number of the charged groups and also structures of the side chain. The higher motility of water could be confirmed by diffusion measurements of nuclear magnetic resonance spectroscopy, and rotation anisotropy by fluorescence spectroscopy.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (37 results)

All 2013 2012 2011 2010 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (29 results) (of which Invited: 1 results) Book (1 results)

  • [Journal Article] Polysaccharide-hair cationic polypeptide nanogels: Self-assembly and enzymaticpolymerization of amylose primer modified cholesteryl poly(L-lysine)2013

    • Author(s)
      N. Morimoto, M. Yamazaki, J. Tamada, K. Akiyoshi
    • Journal Title

      Langmuir

      Volume: (in press) Issue: 24 Pages: 7509-7514

    • DOI

      10.1021/la3047774

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-Assembled pH-Sensitive Cholesteryl Pullulan Nanogel As a Protein Delivery Vehicle2013

    • Author(s)
      Nobuyuki Morimoto, Sayaka Hirano, Haruko Takahashi, Scott Loethen, David H. Thompson, Kazunari Akiyoshi
    • Journal Title

      Biomacromolecules

      Volume: 14 Issue: 1 Pages: 56-63

    • DOI

      10.1021/bm301286h

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae2011

    • Author(s)
      K.Nagano, N.Alles, A.H.Mian, A.Shimoda, N.Morimoto, Y.Tamura, H.Shimokawa, K.Akiyoshi, K.Ohya, K.Aoki
    • Journal Title

      J Bone Miner, Metab

      Volume: 29 Issue: 6 Pages: 671-681

    • DOI

      10.1007/s00774-011-0270-z

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydration properties of adenosine phosphate series as studied by microwave dielectric spectroscopy2011

    • Author(s)
      G. Mogami, T. Wazawa, N. Morimoto, T.Kodama, M. Suzuki
    • Journal Title

      Biophysical Chemistry

      Volume: 154 Issue: 1 Pages: 1-7

    • DOI

      10.1016/j.bpc.2010.11.006

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyper-mobility of water around actin filaments revealed using pulse-field gradient spin-echo 1H-NMR and fluorescence spectroscopy2011

    • Author(s)
      Tetsuichi Wazawa, Takashi Sagawa, Tsubasa Ogawa, Nobuyuki Morimoto, Makoto Suzuki
    • Journal Title

      Biochem.Biophys.Res.Comm.

      Volume: 404 Issue: 4 Pages: 985-990

    • DOI

      10.1016/j.bbrc.2010.12.096

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microwave Absorption Properties of Polymer Modified Ni-Zn Ferrite Nanoparticles2011

    • Author(s)
      K.Shimba, K.Furuta, N.Morimoto, N.Tezuka, S.Sugimoto
    • Journal Title

      MATERIALS TRANSACTIONS

      Volume: 52 Issue: 4 Pages: 740-745

    • DOI

      10.2320/matertrans.MBW201013

    • NAID

      130004454697

    • ISSN
      1345-9678, 1347-5320
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyper-mobility of water around actin filaments revealed using pulse-field gradient spin-echo ^1H NMR and fluorescence spectroscopy2011

    • Author(s)
      T.Wazawa, T.Sagawa, T.Ogawa, N.Morimoto, T.Kodama, M.Suzuki
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 404 Pages: 985-990

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Winnik Francoiseスルホベタインを内殻に有するナノ粒子の調製2012

    • Author(s)
      村松かんな、森本展行、戸井田さやか、鈴木誠
    • Organizer
      日本バイオマテリアル学会大会シンポジウム2012
    • Place of Presentation
      仙台
    • Year and Date
      2012-11-26
    • Related Report
      2012 Final Research Report
  • [Presentation] Design of poly(NIPAM)s for Thermoresponsive Nanoassemblies International Conference on Emerging Advanced2012

    • Author(s)
      N. Morimoto, X.-P. Qiu, K. Akiyoshi, F. M. Winnik
    • Organizer
      Nanomaterials-2012 (ICEAN2012)
    • Place of Presentation
      Brisbane, Australia
    • Year and Date
      2012-10-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 時間分解蛍光偏光法によるタンパク質周囲の水和層の局所粘性測定2012

    • Author(s)
      和沢鉄一,最上譲二,森本展行,石田誠宜,鈴木誠
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 重合制御したスルホベタインブロックコポリマーの調製と会合特性2012

    • Author(s)
      森本展行、村松かんな、鈴木誠
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Preparation of Biocompatible and Thermoresponsive polybetaine nanoparticles. International Association of Colloid and Interface Scientists2012

    • Author(s)
      N. Morimoto, K. Muramatsu, M. Suzuki, A. Moquin, S. Toita, F. M. Winnik
    • Organizer
      Conference (IACIS2012)
    • Place of Presentation
      Sendai, Japan
    • Year and Date
      2012-05-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 誘電緩和分光法による各種カチオン性ポリマーの水和構造解析2011

    • Author(s)
      森本展行、小川翼、最上譲二、鈴木誠
    • Organizer
      第33回日本バイオマテリアル学会大会
    • Place of Presentation
      京都
    • Year and Date
      2011-11-22
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 精密誘電分光測定によるカチオン性ポリマーの水和構造解析2011

    • Author(s)
      森本展行、小川翼、最上譲二、鈴木誠
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山
    • Year and Date
      2011-09-30
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 精密誘電分光測定によるポリ(ビニルホスホン酸)の水和構造解析2011

    • Author(s)
      佐々木優、丹野則彦、最上譲二、和沢鉄一、森本展行、鈴木誠
    • Organizer
      第60回高分子討論会
    • Place of Presentation
      岡山
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] ポリ(アミドアミン)デンドリマーの水和状態解析2011

    • Author(s)
      森本展行、小川翼、最上譲二、鈴木誠
    • Organizer
      第60回高分子学会年次大会
    • Place of Presentation
      大阪
    • Year and Date
      2011-05-26
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] Acid labile self-assembled nanogel by hydrophobized polysaccharide for drug carrier2010

    • Author(s)
      N. Morimoto, S. Hirano, H. Takahashi, DH. Thompson, K. Akiyoshi
    • Organizer
      The International Chemical Congress of Pacific Basin Societies(PacifiChem2010)
    • Place of Presentation
      Hawaii
    • Year and Date
      2010-12-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Acid labile self-assembled nanogel by hydrophobized polysaccharide for drug carrier2010

    • Author(s)
      N.Morimoto, S.Hirano, H.Takahashi, DH.Thompson, K.Akiyoshi
    • Organizer
      The International Chemical Congress of Pacific Basin Societies (PacifiChem2010)
    • Place of Presentation
      ハワイ,アメリカ
    • Year and Date
      2010-12-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] 誘電緩和分光法によるDNA・RNAオリゴマーの水和状態解析2010

    • Author(s)
      土子哲、田中好幸、和沢鉄一、森本展行、鈴木誠
    • Organizer
      日本生物物理学会第48回年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] アクチン周囲の水の運動性はアクチンの重合によって増加する日本生物物理学会2010

    • Author(s)
      和沢鉄一、佐川貴志、小川翼、森本展行、鈴木誠
    • Organizer
      第48回年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-23
    • Related Report
      2012 Final Research Report
  • [Presentation] アクチン周囲の水の運動性はアクチンの重合によって増加する2010

    • Author(s)
      和沢鉄一、佐川貴志、小川翼、森本展行、鈴木誠
    • Organizer
      日本生物物理学会第48回年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Acto-S1により加水分解を受けるATP水溶液の誘電緩和分光法による連続測定2010

    • Author(s)
      長田達也、安居慎一郎、和沢鉄一、最上譲二、森本展行、鈴木誠
    • Organizer
      日本生物物理学会第48回年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ポリ(L-リジン)のコンホメーション変化に伴う動的水和水の解析2010

    • Author(s)
      森本展行、徳田夏樹、土子哲、鈴木誠
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-15
    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Presentation] 誘電緩和分光法によるDNA・RNAオリゴマーの水和状態解析2010

    • Author(s)
      土子哲、田中好幸、和沢鉄一、森本展行、鈴木誠
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] カチオン性デンドリマーの動的水和構造解析2010

    • Author(s)
      小川翼、森本展行、鈴木誠
    • Organizer
      第59回高分子討論会
    • Place of Presentation
      札幌
    • Year and Date
      2010-09-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Design of poly(NIPAM)s for Thermoresponsive Nanoassemblies

    • Author(s)
      Nobuyuki Morimoto
    • Organizer
      International Conference on Emerging Advanced NAnomaterials-2012(ICEAN2012)
    • Place of Presentation
      Brisbane, Australia
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Preparation of Biocompatible and Thermoresponsive polybetaine nanoparticles

    • Author(s)
      Nobuyuki Morimoto
    • Organizer
      International Association of Colloid and Interface Scientists, Conference (IACIS2012)
    • Place of Presentation
      Sendai, Japan
    • Related Report
      2012 Annual Research Report
  • [Presentation] テレケリック型温度応答性ポリマーによる二分子膜の調製と機能解析

    • Author(s)
      佐々木優
    • Organizer
      日本バイオマテリアル学会大会シンポジウム2012
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] スルホベタインを内殻に有するナノ粒子の調製

    • Author(s)
      村松かんな
    • Organizer
      日本バイオマテリアル学会大会シンポジウム2012
    • Place of Presentation
      仙台
    • Related Report
      2012 Annual Research Report
  • [Presentation] 誘電緩和分光法によるアルキルカルボン酸の水和特性

    • Author(s)
      王楊天
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 誘電緩和分光測定によるオリゴリン酸塩の水和解析

    • Author(s)
      石杜和希
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 時間分解蛍光偏光法によるタンパク質周囲の水和層の局所粘性測定

    • Author(s)
      和沢鉄一
    • Organizer
      第50回日本生物物理学会年会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 側鎖にPEG 鎖を導入したスルホベタインコポリマーの会合特性と機能

    • Author(s)
      村松かんな
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 重合制御したスルホベタインブロックコポリマーの調製と会合特性

    • Author(s)
      森本展行
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] テレケリック型ポリ(N-イソプロピルアクリルアミド)の合成と水溶液特性解析

    • Author(s)
      佐々木優
    • Organizer
      第61回高分子討論会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] スルホベタインポリマーのナノ会合体形成と温度応答制御

    • Author(s)
      森本展行
    • Organizer
      第61回高分子学会年次大会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Book] Self- assembled nanogel Engineering2010

    • Author(s)
      N. Morimoto, K. Akiyoshi
    • Publisher
      Biomedical Applications of Hydrogels Handbook.Springer
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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