Design of biomaterials based on the analysis of hydration dynamics around polyelectrolytes
| Project/Area Number |
22680039
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | 水和 / 高分子電解質 / 誘電緩和分光測定 / ナノキャリア / 蛍光異方性 / 高分子構造・物性 / 生体材料 / バイオテクノロジー |
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| Research Abstract |
Dynamic hydration structures around charged molecules and polymers were evaluated by measurements of dielectric relaxation spectroscopy and the mathematical analysis. By accurate control of temperature, we could confirm water around the solutes with the higher relaxation frequency than that of bulk water. The existence of the water was depended on functional groups, number of the charged groups and also structures of the side chain. The higher motility of water could be confirmed by diffusion measurements of nuclear magnetic resonance spectroscopy, and rotation anisotropy by fluorescence spectroscopy.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] The tumor necrosis factor type 2 receptor plays a protective role in tumor necrosis factor-α-induced bone resorption lacunae on mouse calvariae2011
Author(s)
K.Nagano, N.Alles, A.H.Mian, A.Shimoda, N.Morimoto, Y.Tamura, H.Shimokawa, K.Akiyoshi, K.Ohya, K.Aoki
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Journal Title
J Bone Miner, Metab
Volume: 29
Issue: 6
Pages: 671-681
DOI
Related Report
Peer Reviewed
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