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Development of two dimensional beam monitor using position sensitive gas detector for accelerator-based neutron capture therapy

Research Project

Project/Area Number 22680044
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Medical systems
Research InstitutionKyoto University

Principal Investigator

TANAKA Hiroki  京都大学, 原子炉実験所, 助教 (70391274)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2010: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Keywords中性子捕捉療法 / 加速器中性子源 / 二次元中性子モニタ / リアルタイムモニタ / 二次元モニタ / ガス検出器 / 線量評価
Research Abstract

At Kyoto University Research Reactor Institute, accelerator based epithermal neutron source have developed for boron neutron capture therapy. The sufficient epithermal neutron intensity was successfully obtained for the first in the world. It is desired that the treatment beam should be evaluate, because the characteristics is different from the reactor based neutron source that have been used clinical studies. In this study, the real-time beam monitor using position sensitive gas detector that has the sensitivity of fast and thermal neutron was successfully developed.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (34 results)

All 2013 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 11 results) Presentation (20 results)

  • [Journal Article] Radiosensitivity of pimonidazole-unlabelled intratumour quiescent cell population to γ-rays, accelerated carbon ion beams and boron neutron capture reaction, S.-I2013

    • Author(s)
      Masunaga, Y. Sakurai, H. Tanaka, et al
    • Journal Title

      British Journal of Radiology

      Volume: 86(1021) Issue: 1021 Pages: 20120302-20120302

    • DOI

      10.1259/bjr.20120302

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induced radioactivity in the blood of cancer patients following boron neutron capture therapy2013

    • Author(s)
      Keiko Fujiwara,Yuko Kinashi, Tomoyuki Takahashi, Hiroshi Yashima, Kouta Kurihara, Yoshinori Sakurai, Hiroki Tanaka, Koji Ono,Sentaro Takahashi (Keiko Fujiwara)
    • Journal Title

      Journal of radiation research

      Volume: 54(3) Issue: 4 Pages: 1-6

    • DOI

      10.1093/jrr/rrt005

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of bevacizumab treatment on p-boronophenylalanine distribution in murine tumor2013

    • Author(s)
      Y. Liu
    • Journal Title

      J Radiat Res.

      Volume: 54(2) Issue: 2 Pages: 260-267

    • DOI

      10.1093/jrr/rrs102

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reirradiation for locally recurrent lung cancer in the chest wall with boron neutron2012

    • Author(s)
      Suzuki M.
    • Journal Title

      International Cancer Conference Journal

      Volume: 1 Issue: 4 Pages: 235-238

    • DOI

      10.1007/s13691-012-0048-8

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluating the Usefulness of a Novel 10B-Carrier Conjugated With Cyclic RGD Peptide in Boron Neutron Capture Therapy,S.-I2012

    • Author(s)
      Masunaga,S. Kimura,T. Harada,K. Okuda,Y. Sakurai,H. Tanaka,et al
    • Journal Title

      World J Oncol

      Volume: 3(3) Pages: 103-112

    • DOI

      10.4021/wjon477w

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Emplying a 10B-carrier and Manipulating Intratumor Hypoxia on Local Tumor Response and Lung Metastatic Potential in Boron Neutron Capture Therapy2012

    • Author(s)
      S. Masunaga
    • Journal Title

      Br. J. Radiol.

      Volume: 85 Issue: 1011 Pages: 249-258

    • DOI

      10.1259/bjr/20974899

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of two dimensional thermal neutron flux monitor using multi-wire proportional counter for boron neutron capture therapy2012

    • Author(s)
      Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki,Shin-ichiro Masunaga,Masahiro Hino, Yuko Kinashi, Koji Ono, Akira Maruhashi (Hiroki Tanaka)
    • Journal Title

      IEEE Nuclear Science Symposium Conference Record

      Volume: 2012

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Experimental verification of beam characteristics for cyclotron-based epithermal neutron source(C-BENS)2011

    • Author(s)
      H. Tanaka, et. al.
    • Journal Title

      Applied Radiation and Isotopes

      Volume: Volume 69 Issue: 12 Pages: 1642-1645

    • DOI

      10.1016/j.apradiso.2011.03.020

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The optimization study of Bonner sphere in the epi-thermalneutron irradiation field for BNCT2011

    • Author(s)
      H.Ueda, H.Tanaka, A.Maruhashi, K.Ono, Y.Sakurai
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69 Issue: 12 Pages: 1657-1659

    • DOI

      10.1016/j.apradiso.2011.01.034

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aphantom experiment for the evaluation of whole body exposure during BNCT using cyclotron-based epithermal neutron source(C-BENS)2011

    • Author(s)
      T. Tsukamoto, H. Tanaka, et. al.
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69(12) Issue: 12 Pages: 1830-1833

    • DOI

      10.1016/j.apradiso.2011.03.013

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation for activities of component of Cyclotron-Based Epithermal Neutron Source(C-BENS) and the surface of concrete wallin irradiation room2011

    • Author(s)
      M. Imoto, H. Tanaka, et. al.
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69(12) Issue: 12 Pages: 1646-1648

    • DOI

      10.1016/j.apradiso.2011.03.018

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Study on optimization of multi ionization-chamber system for BNCT2011

    • Author(s)
      T. Fujii, H. Tanaka, et al
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 69(12) Issue: 12 Pages: 1862-1865

    • DOI

      10.1016/j.apradiso.2011.03.031

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Study on thermal neutron detection method using imaging plate and activation2011

    • Author(s)
      H.Tanaka, et.al
    • Journal Title

      Proceeding of International Conference on Medical Physics

      Volume: (CD-ROM) Pages: 370-370

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Development of a Neutron Flux Monitor Using a Small Scintillator Coupled with Quartz Fiber for a Cyclotron-Based Boron Neutron Capture Therapy2010

    • Author(s)
      H.Tanaka, et.al.
    • Journal Title

      2010 IEEE nuclear Science Symposium Conference Record

      Volume: (CD-ROM)

    • Related Report
      2010 Annual Research Report
  • [Presentation] BNCTのための石英ファイバーを用いた熱中性子モニタアレイによる二次元検出器の開発2012

    • Author(s)
      田中浩基 他
    • Organizer
      2012年春季第59回応用物理学関係連合講演会
    • Place of Presentation
      早 稲田
    • Year and Date
      2012-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] BNCTのための石英ファイバーを用いた熱中性子モニタアレイによる二次元検出器の開発2012

    • Author(s)
      田中浩基, 他
    • Organizer
      2012年春季第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学(東京都)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of thermal neutron irradiation field using cyclotron based neutron source for alphaautoradiography2012

    • Author(s)
      H. Tanaka et al
    • Organizer
      15th International Congress on Neutron Capture Therapy
    • Place of Presentation
      つくば
    • Related Report
      2012 Final Research Report
  • [Presentation] Study on dose evaluation at irradiation room using cyclotron based epithermal neutron source for boron neutron capture therapy2012

    • Author(s)
      H. Tanaka et al
    • Organizer
      12th International Conference on Radiation Shielding
    • Place of Presentation
      奈良
    • Related Report
      2012 Final Research Report
  • [Presentation] 中性子捕捉療法のためのマルチワイヤ検出器を用いた二次元中性子検出器の開発2012

    • Author(s)
      田中浩基 他
    • Organizer
      日本原子力学会 2012年秋の年会
    • Place of Presentation
      広島
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of two dimensional thermal neutron flux monitor using multi-wire proportional counter for boron neutron capture therapy2012

    • Author(s)
      H. Tanaka et al
    • Organizer
      Development of two dimensional thermal neutron flux monitor using multi-wire proportional counter for boron neutron capture therapy
    • Place of Presentation
      Anaheim, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Evaluation of thermal neutron irradiation field using cyclotron based neutron source for alpha autoradiography2012

    • Author(s)
      Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Shin-ichiro Masunaga, Toshinori Mitsumoto, Yuko Kinashi, Koji Ono, Akira Maruhashi (Hiroki Tanaka)
    • Organizer
      15th International Congress on Neutron Capture Therapy
    • Place of Presentation
      つくば国際会議場(茨城県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Study on dose evaluation at irradiation room using cyclotron based epithermal neutron source for boron neutron capture therapy2012

    • Author(s)
      Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki, Shin-ichiro Masunaga, Toshinori Mitsumoto, Yuko Kinashi, Akira Maruhashi, Koji Ono(Hiroki Tanaka)
    • Organizer
      12th International Conference on Radiation Shielding
    • Place of Presentation
      奈良県新公会堂(奈良県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 中性子捕捉療法のためのマルチワイヤ検出器を用いた二次元中性子検出器の開発2012

    • Author(s)
      田中浩基、櫻井良憲、鈴木実、増永慎一郎、日野正裕、木梨友子、丸橋晃、小野公二(田中浩基)
    • Organizer
      日本原子力学会 2012年秋の年会
    • Place of Presentation
      広島大学東広島キャンパス(広島県)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Development of two dimensional thermal neutron flux monitor using multi-wire proportional counter for boron neutron capture therapy2012

    • Author(s)
      Hiroki Tanaka, Yoshinori Sakurai, Minoru Suzuki,Shin-ichiro Masunaga,Masahiro Hino, Yuko Kinashi, Koji Ono, Akira Maruhashi (Hiroki Tanaka)
    • Organizer
      2012 Nuclear Science Symposium, Medical Imaging Conference
    • Place of Presentation
      Anaheim,USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 京都大学原子炉実験所におけるBNCT用サイクロトロンを用いた熱外中性子源の概要2011

    • Author(s)
      田中浩基 他
    • Organizer
      日本原子力学会2011年秋の年会
    • Place of Presentation
      北九州
    • Year and Date
      2011-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 京都大学原子炉実験所におけるBNCT用サイクロトロンを用いた熱外中性子源の概要2011

    • Author(s)
      田中浩基, 他
    • Organizer
      日本原子力学会2011年秋の年会
    • Place of Presentation
      北九州国際会議場(福岡県)
    • Year and Date
      2011-09-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of thermal neutron flux monitor using small scintillator array coupled with quartz fibers for Boron Neutron Capture Therapy2011

    • Author(s)
      H. Tanaka et al
    • Organizer
      2011 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      Valencia, Spain
    • Related Report
      2012 Final Research Report
  • [Presentation] 石英ファイバーとシンチレータを 用いた中性子捕捉療法用中性子モニタの開発2010

    • Author(s)
      田中浩基 他
    • Organizer
      原子力学会2010年秋の大会
    • Place of Presentation
      北海道
    • Related Report
      2012 Final Research Report
  • [Presentation] サイクロトロンベース熱外中性子源のマイクロドシメトリを用いた線質評価2010

    • Author(s)
      田中浩基 他
    • Organizer
      第7回日本中性子捕捉療法学会
    • Place of Presentation
      学習院大
    • Related Report
      2012 Final Research Report
  • [Presentation] Development of a Neutron Flux Monitor Using a Small Scintillator Coupled with Quartz Fiber for a Cyclotron-Based Boron Neutron Capture Therapy2010

    • Author(s)
      H. Tanaka et. al
    • Organizer
      2011 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      Knoxville, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] Beam property of intense epithermal neutron source based on Be(p,n) reaction using cyclotron accelerator for boron neutron capture therapy2010

    • Author(s)
      H.Tanaka, et.al.
    • Organizer
      第49回粒子線治療世界会議
    • Place of Presentation
      グリーンドーム前橋
    • Related Report
      2010 Annual Research Report
  • [Presentation] サイクロトロンベース熱外中性子源のマイクロドシメトリを用いた線質評価2010

    • Author(s)
      田中浩基, 他
    • Organizer
      第7回日本中性子捕捉療法学会
    • Place of Presentation
      学習院大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] 石英ファイバーとシンチレータを用いた中性子捕捉療法用中性子モニタの開発2010

    • Author(s)
      田中浩基, 他
    • Organizer
      原子力学会2010年秋の大会
    • Place of Presentation
      北海道大学
    • Related Report
      2010 Annual Research Report
  • [Presentation] Beam property of intense epithermal neutron source based on Be(p,n) reaction using cyclotron accelerator for boron neutron capture therapy

    • Author(s)
      H. Tanaka et. al
    • Organizer
      第49回粒子線治療世界会議
    • Place of Presentation
      前橋
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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