Development of novelneurorehabiIi tat ion to restore locomotorfunction after spinal cord injury

• Project/Area Number: 22680045
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: National Rehabilitation Center for Persons with Disabilities
• Principal Investigator: 河島 則天 国立障害者リハビリテーションセンター(研究所), 研究所運動機能系障害研究部, 室長 (30392195)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000); Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2011: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2010: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
• Keywords: 脊髄損傷 / 歩行 / リハビリテーション / 神経可塑性

Research Abstract

The purpose of this project is to develop a novel neuro rehabilitation approach to restore locomotor function after spinal cord injury. We paid attention to an enhancement of spinal central pattern generator (CPG) which is an important element for the generation of locomotive motor outputs. We found that combination of robotic gait assist and additional voluntary commands suitably enhanced the phase modulation of lower limb muscle activities. We also found that the degree of spasticity was gradually decreased with the time course of 12 weeks of gait training. These results provide useful information for establishing a novel and an effective neuro-rehabilitation approaches for the restoration of gait function after spinal cord injury.

Research Products

• [Journal Article] Effect of intensive functional electrical stimulation therapy on the upper limb motor recovery after stroke: Single case study of a chronic stroke patient (2013)
  • Author(s): Kawashima N, Popovic MR, Zivanovic V
  • Journal Title: Physiotherapy Canada Volume: 65(1) Pages: 20-28
  • Peer Reviewed
• [Journal Article] 歩行運動を実現する神経システム (2012)
  • Author(s): 河島則天、小川哲也
  • Journal Title: 理学療法 Volume: Vol.29(7) Pages: 727-734
• [Journal Article] Different modulation pattern of the spinal stretch reflex excitability in well-trained athletes (2012)
  • Author(s): Ogawa T, Kawashima N, Suzuki S, and Nakazawa K
  • Journal Title: Eur J Appl Physiol Volume: 112 Pages: 3641-3648
  • Peer Reviewed
• [Journal Article] Novel gait orthosis for SCI patients with motor-assisted knee flexion (2012)
  • Author(s): Akahira H, Yamaguchi Y, Nakazawa K, Ohta Y and Kawashima N
  • Journal Title: J Novel Physiotherapy Volume: 2 Issue: S1
  • DOI: 10.4172/2165-7025.s1-004
  • Peer Reviewed
• [Journal Article] Limited transfer of newly acquired movement patterns across walking and running in humans. (2012)
  • Author(s): Ogawa T, Kawashima N, Ogata T, Nakazawa K
  • Journal Title: PLoS One Volume: 7 Issue: 9 Pages: e46349-e46349
  • DOI: 10.1371/journal.pone.0046349
  • Peer Reviewed
• [Journal Article] 超音波画像を用いた脊髄損傷者の麻痺筋特性の定量的評価 (2011)
  • Author(s): 根岸大輔、加藤えみか、太田裕治、山本紳一郎、河島則天
  • Journal Title: 生体医工学 Volume: 49(6) Pages: 789-797
  • NAID: 130004947495
  • Peer Reviewed
• [Journal Article] Novel gait orthosis for SCI patients with motor-assisted knee flexion
  • Author(s): Akahira H, Yamaguchi Y, Nakazawa K, Ohta Y and Kawashima N
  • Journal Title: J Novel Physiotherapy Volume: (in press)
  • Peer Reviewed
• [Journal Article] Limited transfer of newly acquired movement patterns across walking and running in humans
  • Author(s): Ogawa T, Kawashima N, Ogata T, Nakazawa K
  • Journal Title: PLoS One Volume: 7(9)
  • Peer Reviewed
• [Journal Article] Popovic MR. Exercise Intensity during Treadmill Walking with Gait Patterned FES among Patients with Incomplete Spinal Cord Injury: Case Series
  • Author(s): Miyatani M, Masani K, Kawashima N, Craven C, Thrasher A
  • Journal Title: ISRN Rehabilitation Volume: Volume 2012, Article ID 251750 Pages: 6-6
  • Peer Reviewed
• [Presentation] 立位姿勢調節の加齢変化～重心動揺に対する下腿三頭筋応答性の観点から～ (2012)
  • Author(s): 井原壽一、山本紳一郎、岩谷力、河島則天
  • Organizer: LIFE2012生活生命支援医療福祉工学系学会連合大会
  • Place of Presentation: 名古屋
• [Presentation] 脊髄損傷者の麻痺領域に発現する歩行様筋活動の長期適応効果 (2012)
  • Author(s): 河島則天、中澤公孝
  • Organizer: 第6回Motorcontrol研究会
  • Place of Presentation: 愛知
• [Presentation] 脊髄不全損傷者におけるロボティクスを用いた歩行リハビリ前後の歩行動作の変化 (2012)
  • Author(s): 高橋智大、小川哲也、河島則天、緒方徹、山本紳一郎
  • Organizer: 第24回バイオエンジニアリング講演会
  • Place of Presentation: 大阪
• [Presentation] 脊髄損傷後の足関節スティフネス特性の変化 (2012)
  • Author(s): 新美未幸、河島則天、太田裕治
  • Organizer: 化第24回バイオエンジニアリング講演会
  • Place of Presentation: 大阪
• [Presentation] 神経科学から見たリハビリテーションの未来とその可能性 (2012)
  • Author(s): 河島則天
  • Organizer: 平成23年度京都府理学療法土会
  • Place of Presentation: 京都(招待講演)
• [Presentation] リハビリテーション領域における動作解析の活用 (2011)
  • Author(s): 河島則天
  • Organizer: MAC3Dユーザーミーティング2011
  • Place of Presentation: 東京
• [Presentation] 曲線上歩行による歩行非対称性の改善 (2011)
  • Author(s): 河島則天、小川哲也
  • Organizer: 第5回Motorcontrol研究会
  • Place of Presentation: 愛知
• [Presentation] 同一速度下の歩行・走行間における学習効果の転移の有無 (2011)
  • Author(s): 小川哲也、河島則天、緒方徹、中澤公孝
  • Organizer: 第5回Motorcontro1研究会
  • Place of Presentation: 愛知
• [Presentation] リハビリテーション領域における動作解析の活用 (2011)
  • Author(s): 河島則天
  • Organizer: MAC3Dユーザーミーティング2011
  • Place of Presentation: 京都
• [Presentation] 脊髄不全損傷者の歩行動作特性 (2011)
  • Author(s): 高橋智大・河島則天, 他
  • Organizer: 第23回バイオエンジニアリング講演会
  • Place of Presentation: 熊本
• [Presentation] 動力歩行装置Lokomatを用いた歩行訓練の効果
  • Author(s): 河島則天
  • Organizer: 第４９回日本リハビリテーション医学会
  • Place of Presentation: 福岡国際会議場（福岡県）
  • Invited
• [Presentation] Toward gait recovery after spinal cord injury
  • Author(s): Noritaka Kawashima
  • Organizer: ICORD seminer series
  • Place of Presentation: International Coraboration of Recovery Discovery, Britich Colombia, Canada
  • Invited
• [Book] 運動療法ガイド (2012)
  • Author(s): 河島則天
  • Total Pages: 17
  • Publisher: 日本医事新報社
• [Remarks]
  • URL: http://www.rehab.go.jp/ri/undou/motorcontrolsection_j.htm