The novel nutrient sensing mechanism and development of disease prophylaxis

• Project/Area Number: 22680053
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Eating habits, studies on eating habits
• Research Institution: The University of Tokushima
• Principal Investigator: YAMOMOTO Hironori 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (60314861)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000); Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
• Keywords: 健康と食生活 / 栄養センサー / 生活習慣病 / 臓器特異的 / リン感受性遺伝子 / リン酸 / 遺伝子発現 / 臓器間ネットワーク / オミックス医療

Research Abstract

In this study, we worked on the development of disease prevention methods and the discovery of novel nutrition sensor. As a result, thyroid hormone receptors and sterol regulatory binding proteins SREBPs play animportant role as the transcription factor for the transcriptional regulation of CYP27B1 gene which is vitamin D metabolism enzyme. Further, the development of ectopic calcification in the premature aging mouse models having a phosphorus metabolic abnormalities,revealed the possibility of stanniocalcin 2 contributes as a defense factor.

Research Products

• [Journal Article] Takeda E. Role of serine 249 of ezrin in the regulation of sodium-dependent phosphate transporter NaPi-IIa activity in renal proximal tubular cells. (2013)
  • Author(s): Yamada F, Horie D, Nakamura A, Tanimura A, Yamamoto H, Segawa H, Ito M, Miyamoto K, Taketani Y
  • Journal Title: J Med Invest Volume: 60(1-2) Pages: 27-34
  • URL: http://dx.doi.org/10.2152/jmi.60.27
  • Peer Reviewed
• [Journal Article] Thyroid hormones decrease plasma 1a,25-dihydroxyvitamin D levels through transcriptional repression of the renal 25-hydroxyvitamin D-1a-hydroxylase gene (CYP27B1) (2013)
  • Author(s): Kozai M, Ishiguro M, Harada N.Masuda M, Kagawa T, Takei Y, Ohtani A, Nakahashi O, Ikeda S, Taketani Y.Miyamoto K, Takeyama K, Kato S, Takeda E
  • Journal Title: Endocrinology Volume: 154 Issue: 2 Pages: 609-622
  • DOI: 10.1210/en.2012-1647
  • Peer Reviewed
• [Journal Article] Up-regulation of stanniocalcin 1 expression by 1,25-dihydroxy vitamin D₃ and parathyroid hormone in renal proximal tubular cells (2012)
  • Author(s): Hung NT, Yamamoto H, Takei Y, Masuda M, Otani A, Kozai M, Ikeda S, Nakahashi O, Tanaka S, Taketani Y, Takeda E
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 50 Issue: 3 Pages: 227-233
  • DOI: 10.3164/jcbn.11-99
  • NAID: 130004879277
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells (2012)
  • Author(s): Takei Y, Yamamoto H, Sato T, Otani A, Kozai M, Masuda M, Taketani Y, Muto-Sato K, Lanske B, Takeda E
  • Journal Title: Bone. Volume: 50(4) Issue: 4 Pages: 998-1005
  • DOI: 10.1016/j.bone.2012.01.006
  • Peer Reviewed
• [Journal Article] Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet (2012)
  • Author(s): Uebanso T, Taketani Y, Yamamoto H, Amo K, Tanaka S, Arai H, Takei Y, Masuda M, Yamanaka-Okumura H, Takeda E
  • Journal Title: J Nutr Biochem Volume: 23(7) Pages: 785-790
  • Peer Reviewed
• [Journal Article] Dietary phosphate restriction ameliorates endothelial dysfunction in adenine-induced kidney disease rats (2012)
  • Author(s): Tan Vu Van, et al
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 51 Issue: 1 Pages: 27-32
  • DOI: 10.3164/jcbn.11-96
  • NAID: 130004879287
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Reply to Letter to the Editor “On the role of the type III phosphate transporters in vascular calcification” (2012)
  • Author(s): Yamamoto H et al
  • Journal Title: Bone Volume: 51 Issue: 4 Pages: 829-829
  • DOI: 10.1016/j.bone.2012.07.006
  • Peer Reviewed
• [Journal Article] Natto and viscous vegetables in a Japanese-style breakfast improved insulin sensitivity (2011)
  • Author(s): Taniguchi-Fukatsu A, Yamanaka-Okumura H, Naniwa-Kuroki Y, Nishida Y, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: lipid metabolism and oxidative stress in overweight subjects with impaired glucose tolerance Volume: 7 Issue: 8 Pages: 1-8
  • DOI: 10.1017/s0007114511004156
  • Peer Reviewed
• [Journal Article] High phosphate diet reduces atherosclerosis formation in apolipoprotein E-deficient mice (2011)
  • Author(s): Shiota A, Taketani Y, Maekawa Y, Yasutomo K, Sata M, Sakai T, Mizuno R, Isshiki M, Yamamoto H, Takeda E
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 49 Issue: 2 Pages: 109-114
  • DOI: 10.3164/jcbn.10-150
  • NAID: 130004466642
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Liver X receptor negatively regulates fibroblast growth factor 21 in the fatty liver induced by cholesterol-enriched diet (2011)
  • Author(s): Uebanso T, Taketani Y, Yamamoto H, Amo K, Tanaka S, Arai H, Takei Y, Masuda M, Yamanaka-Okumura H, Takeda E
  • Journal Title: J Nutr Biochem Volume: 23 Issue: 7 Pages: 785-790
  • DOI: 10.1016/j.jnutbio.2011.03.023
  • Peer Reviewed
• [Journal Article] Effects of xylitol on metabolic parameters and visceral fat accumulation (2011)
  • Author(s): Amo K, Arai H, Uebanso T, Fukaya M, Koganei M, Sasaki H, Yamamoto H, Taketani Y, Takeda E
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 49 Issue: 1 Pages: 1-7
  • DOI: 10.3164/jcbn.10-111
  • NAID: 130004879256
  • ISSN: 0912-0009, 1880-5086
  • Peer Reviewed
• [Journal Article] Paradoxical Regulation of Human FGF21 by Both Fasting and Feeding Signals : Is FGF21 a Nutritional Adaptation Factor? (2011)
  • Author(s): Uebanso T, Taketani Y, Yamamoto H, Amo K, Ominami H, Arai H, Takei Y, Masuda M, Tanimura A, Harada N, Yamanaka-Okumura H, Takeda E
  • Journal Title: PLoS One Volume: 6(8) Issue: 8 Pages: 22976-22976
  • DOI: 10.1371/journal.pone.0022976
  • Peer Reviewed
• [Journal Article] Vibrio parahaemolyticus infection induces modulation of IL-8 secretion through dual pathway via VP1680 in Caco-2 cells. (2011)
  • Author(s): Shimohata T
  • Journal Title: J Infect Dis. Volume: 15;203(4) Pages: 537-544
  • Peer Reviewed
• [Journal Article] Analysis of different complexes of type IIa sodium-dependent phosphate transporter in rat renal cortex using blue-native polyacrylamide gel electrophoresis. (2011)
  • Author(s): Tanimura A
  • Journal Title: J Med Invest. Volume: 8(1-2) Pages: 140-147
  • Peer Reviewed
• [Journal Article] Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice (2010)
  • Author(s): Mukai R, Nakao R, Yamamoto H, Nikawa T, Takeda E, Terao J
  • Journal Title: J Nat Prod Volume: 73(10) Issue: 10 Pages: 1708-1710
  • DOI: 10.1021/np100240y
  • Peer Reviewed
• [Journal Article] Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors (2010)
  • Author(s): Masuda M, Yamamoto H, Kozai M, Tanaka S, Ishiguro M, Takei Y, Nakahashi O, Ikeda S, Uebanso T, Taketani Y, Segawa H, Miyamoto K, Takeda E.
  • Journal Title: Biochem J. Volume: 492 Issue: 3 Pages: 583-592
  • DOI: 10.1042/bj20100484
  • Peer Reviewed
• [Journal Article] Regulation of renal sodium-dependent phosphate co-transporter genes (Npt2a and Npt2c) by all-trans-retinoic acid and its receptors. (2010)
  • Author(s): Masuda M
  • Journal Title: Biochem J. Volume: 1;429(3) Pages: 538-592
  • Peer Reviewed
• [Journal Article] Quercetin Prevents Unloading-Derived Disused Muscle Atrophy by Attenuating the Induction of Ubiquitin Ligases in Tail-Suspension Mice. (2010)
  • Author(s): Mukai R
  • Journal Title: J Nat Prod. Volume: 73;10 Pages: 1708-1710
  • Peer Reviewed
• [Journal Article] Protective effects of glycoglycerolipids extracted from spinach on 5-fluorouracil induced intestinal mucosal injury. (2010)
  • Author(s): Shiota A
  • Journal Title: J Med Invest. Volume: 57(3-4) Pages: 314-320
  • Peer Reviewed
• [Presentation] Regional Up-regulation of 25-hydroxyvitamin D 1 alpha-hydroxylase (CYP27B1) Gene Is Associated with the Pathogenesis of Ectopic Calcification in the Alpha Klotho Mutant Mice (2012)
  • Author(s): Yamamoto H, Otani A, Yokoyama N, Onishi R, Yakei Y, Taketani Y, Miyamoto K, Takeda E
  • Organizer: 34th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Minneapolis convention center, (Minnesota, USA)
• [Presentation] Induction of the Intact and C-terminal FGF23 Levels and Its Gene Expression in Lipopolysaccharide- Induced Acute Inflammation (2012)
  • Author(s): Ikeda S, Yamamoto H, Nakahashi O, Kozai M, Taketani Y, Takeda E
  • Organizer: 34th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Minneapolis convention center, (Minnesota, USA)
• [Presentation] Dietary Phosphorus Restriction Up-regulates the Ileal Fibroblast Growth Factor 15 Gene Expression through the Vitamin D Receptor Activation (2012)
  • Author(s): Nakahashi O, Yamamoto H, Tanaka S, Kozai M, Taketani Y, Miyamoto K-I, Kato S, Takeda E
  • Organizer: 34th Annual Meeting of the American Society for Bone and Mineral Research (ASBMR)
  • Place of Presentation: Minneapolis convention center, (Minnesota, USA)
• [Presentation] リン・カルシウムバランスが肝臓時計遺伝子および脂質代謝の日内リズムに与える影響 (2012)
  • Author(s): 山本浩範
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道大学、(北海道)
• [Presentation] 生体リン・ビタミン D 代謝の概日リズムの分子機構の解明 (2012)
  • Author(s): 山本浩範、向原理恵、中橋乙起、池田翔子、香西美奈、竹谷豊、武田英二
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル、(東京都)
• [Presentation] αKlotho-Fgf23 シグナル異常による 25-ヒドロキシビタミン D3-1α水酸化酵素(CYP27B1)発現亢進と異所性石灰化発症の分子機構の解明 (2012)
  • Author(s): 山本浩範、大谷彩子、横山望、香西美奈、池田翔子、竹谷豊、武田英二
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル、(東京都)
• [Presentation] リン・ビタミン D 代謝の概日リズムの解析 (2012)
  • Author(s): 向原理恵、山本浩範、中橋乙起、池田翔子、香西美奈、竹谷豊、武田英二
  • Organizer: 日本ビタミン学会第64回大会
  • Place of Presentation: 長良川国際会議場、(岐阜県)
• [Presentation] レチノイン酸は IIb 型リン酸トランスポーターNpt2b発現を抑制し小腸リン吸収を低下させる (2012)
  • Author(s): 山本浩範、増田真志、田中更沙、香西美奈、竹谷豊、宮本賢一、武田英二
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学、(宮城県)
• [Presentation] INTERACTION BETWEEN DIETARY PHOSPHATE AND CARBOHYDRATE ON GLUCOSE AND PHOSPHATE METABOLISMS IN HEALTHY YOUNG MEN (2012)
  • Author(s): Taketani Y et al
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease 2012 the First World Renal Nutrition Week
  • Place of Presentation: Hilton Hawaiian Village, Honolulu, Hawaii (USA)
• [Presentation] THE EXPRESSION PROFILING OF INTESTINAL NUTRIENT TRANSPORTER GENES IN RATS WITH RENAL FAILURE (2012)
  • Author(s): Yamamoto H et al
  • Organizer: XVI International Congress on Nutrition and Metabolism in Renal Disease 2012 the First World Renal Nutrition Week
  • Place of Presentation: Hilton Hawaiian Village, Honolulu, Hawaii (USA)
• [Presentation] Regional Up-regulation of 25-hydroxyvitamin D 1 alpha-hydroxylase (CYP27B1) Gene Is Associated with the Pathogenesis of Ectopic Calcification in the Alpha Klotho Mutant Mice. (2012)
  • Author(s): Yamamoto H et al
  • Organizer: ASBMR 2012
  • Place of Presentation: Minneapolis Convention Center, Minneapolis, Minnesota (USA)
• [Presentation] Induction of the Intact and C-terminal FGF23 Levels and Its Gene Expression in Lipopolysaccharide-Induced Acute Inflammation. (2012)
  • Author(s): Ikeda S et al
  • Organizer: ASBMR 2012
  • Place of Presentation: Minneapolis Convention Center, Minneapolis, Minnesota (USA)
• [Presentation] Dietary Phosphorus Restriction Up-regulates the Ileal Fibroblast Growth Factor 15 Gene Expression through the Vitamin D Receptor Activation (2012)
  • Author(s): Nakahashi O et al
  • Organizer: ASBMR 2012
  • Place of Presentation: Minneapolis Convention Center, Minneapolis, Minnesota (USA)
• [Presentation] Dietary Phosphate Restriction Prevents Renal Anemia in Chronic Kidny Disease Model Rats (2012)
  • Author(s): Nakao M et al
  • Organizer: ASN Kidney week 2012
  • Place of Presentation: San Diego Convention Center, SanDiego (USA)
• [Presentation] レチノイン酸はIIb型リン酸トランスポーターNpt2b発現を抑制し小腸リ ン吸収を低下させる (2012)
  • Author(s): 山本浩範 他
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学（ 宮城県）
• [Presentation] リン制限食による腎性貧血改善効果 (2012)
  • Author(s): 中尾真理 他
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学（ 宮城県）
• [Presentation] 炎症性腸疾患の発症および治癒過程におけるリン摂取量の重要性 (2012)
  • Author(s): 十河未来 他
  • Organizer: 第66回日本栄養・食糧学会大会
  • Place of Presentation: 東北大学（ 宮城県）
• [Presentation] リン・ビタミンD代謝の概日リズムの解析 (2012)
  • Author(s): 向原理恵 他
  • Organizer: 日本ビタミン学会第64回大会
  • Place of Presentation: 長良川国際会議場（ 岐阜県）
• [Presentation] 生体リン・ビタミンD代謝の概日リズムの分子機構の解明 (2012)
  • Author(s): 山本浩範 他
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（ 東京都）
• [Presentation] αKlotho-Fgf23シグナル異常による25-ヒドロキシビタミンD3-1α水酸化酵 素(CYP27B1)発現亢進と異所性石灰化発症の分子機構の解明 (2012)
  • Author(s): 山本浩範 他
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 京王プラザホテル（ 東京都）
• [Presentation] リン・カルシウムバランスが肝臓時計遺伝子および脂質代謝の日内リズムに与える影響 (2012)
  • Author(s): 山本浩範 他
  • Organizer: 第19回日本時間生物学会学術大会
  • Place of Presentation: 北海道大学学術交流会館、札幌市（ 北海道）
• [Presentation] Regulation of Phosphate Homeostasis by Steroid/thyroid Hormones and Its Receptors (2011)
  • Author(s): Yamamoto H
  • Organizer: The International Conference on Food Factors (ICoFF 2011)
  • Place of Presentation: 台北(台湾)
  • Year and Date: 2011-11-22
• [Presentation] Thyroid Hormones Decrease the Plasma lalpha, 25-dihydroxyvitamin D3 Levels through Transcriptional Repression of the Renal 25-hydroxyvitamin D3 lalpha-hydroxylase (CYP27B1) Gene (2011)
  • Author(s): Kozai M
  • Organizer: ASN Kidney Week 2011
  • Place of Presentation: Philadelphia, PA (USA)
  • Year and Date: 2011-11-11
• [Presentation] エピジェネティクスと癌～炎症と発癌、栄養食品因子について～ (2011)
  • Author(s): 山本浩範
  • Organizer: 第33回日本臨床栄養学会総会第32回日本臨床栄養協会総会第9回大連合大会
  • Place of Presentation: 都市センターホテル(東京都)
  • Year and Date: 2011-10-28
• [Presentation] Dietary quercetin and onion powder could prevent immobilization induced bone loss in rats (2011)
  • Author(s): Yamamoto H
  • Organizer: 第5回ポリフェノールと健康国際会議(ICPH)
  • Place of Presentation: Barcelona (Spain)
  • Year and Date: 2011-10-18
• [Presentation] Regulation of Renal Sodium-Dependent Phosphate Co-Transporters During Lipopolysaccharide-Induced Acute Inflammation (2011)
  • Author(s): Ikeda S
  • Organizer: American Bone and Mineral Research annual meeting 2011
  • Place of Presentation: San Diego, California (USA)
  • Year and Date: 2011-09-19
• [Presentation] All-Trans-Retinoic Acid Inhibits Intestinal Phosphate Uptake and Type IIb Sodium-Dependent Phosphate Co-Transporter Gene Expression in Rat (2011)
  • Author(s): Yamamoto H
  • Organizer: American Bone and Mineral Research annual meeting 2011
  • Place of Presentation: San Diego, California (USA)
  • Year and Date: 2011-09-18
• [Presentation] 敗血症時におけるリン代謝異常の分子メカニズムの解析 (2011)
  • Author(s): 山本浩範
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2011-07-28
• [Presentation] alpha klotho変異マウスにおける25-hydroxylase(CYP27B1)局所的発現上昇の異所性石 (2011)
  • Author(s): 大谷彩子
  • Organizer: 第63回日本ビタミン学会大会
  • Place of Presentation: 安田女子大学(広島県)
  • Year and Date: 2011-06-05
• [Presentation] All-transレチノイン酸は小腸からのリン吸収を抑制する (2011)
  • Author(s): 山本浩範
  • Organizer: 第63回日本ビタミン学会大会
  • Place of Presentation: 安田女子大学(広島県)
  • Year and Date: 2011-06-04
• [Presentation] レチノイン酸受容体RAR/RXRを介したナトリウム依存性リン酸輸送担体遺伝子の発現調節機構 (2011)
  • Author(s): 山本浩範
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京都)
  • Year and Date: 2011-05-14
• [Presentation] リン制限食によるFibroblast growth factor 15遺伝子発現調節機構 (2011)
  • Author(s): 中橋乙起
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京都)
  • Year and Date: 2011-05-14
• [Presentation] アデニン誘導性CKDモデルラットにおける食事性リン制限は血管内皮機能を改善する (2011)
  • Author(s): 田中輝実
  • Organizer: 第65回日本栄養・食糧学会大会
  • Place of Presentation: お茶の水女子大学(東京都)
  • Year and Date: 2011-05-14
• [Presentation] 腎不全における腸管鉄代謝異常の分子メカニズムの解明 (2011)
  • Author(s): 山本浩範
  • Organizer: 第14回日本病態栄養学会年次学術集会
  • Place of Presentation: 横浜
• [Presentation] 甲状腺疾患におけるビタミンD代謝異常の分子メカニズムの解明 (2010)
  • Author(s): 山本浩範
  • Organizer: 第28回小児代謝性骨疾患研究会
  • Place of Presentation: 大阪
  • Year and Date: 2010-12-04
• [Presentation] Effect of dietary phosphate-loading on endothelial function (2010)
  • Author(s): Taketani Y
  • Organizer: ISN-Nexus Symposium 2010 The Kidney and the Vascular System
  • Place of Presentation: 京都
• [Presentation] Human FGF21 is Paradoxically Induced by both Fasting and Over-Feeding Signals-Is FGF21 a Nutritional Adaptation Factor (2010)
  • Author(s): Uebanso T
  • Organizer: American Diabetes Association (ADA)70th Annual Scientific Sessions
  • Place of Presentation: Orlando、FL, USA
• [Presentation] The Interaction of Dietary Carbohy drate and Fat on Pancreatic Islet Dysfunction Mediated by Glucolipotoxicity (2010)
  • Author(s): Amou K
  • Organizer: American Diabetes Association (ADA)70th Annual Scientific Sessions
  • Place of Presentation: Orlando, FL, USA
• [Presentation] Transrepression of Renal 25-hydroxyvitamin D_3 1α-hydroxylase (CYP27B1) Gene Expression by Thyroid Hormone Receptor β1 (2010)
  • Author(s): Kozai M
  • Organizer: American Society for Bone and Mineral Research (ASBMR) 2010 Annual Meeting
  • Place of Presentation: Toronto, Ontario, CA
• [Presentation] Up-regulation of Stanniocalcin 2 Expression by the Abnormality of Klotho-Fgf23 Signaling and Inhibition of Phosphate-induced Calcification in Aortic Vascular Smooth Muscle Cells (2010)
  • Author(s): Takei Y
  • Organizer: American Society for Bone and Mineral Research (ASBMR) 2010 Annual Meeting
  • Place of Presentation: Toronto, Ontario, CA
• [Presentation] All-trans retinoic acid maintains the blood phosphate levels through the positive and negative regulation of type II sodium-dependent phosphateco-transporter family genes in kidney and intestine (2010)
  • Author(s): Masuda M
  • Organizer: American Society of Nephrology Renal Week 2010
  • Place of Presentation: Denver, CO, USA
• [Presentation] Regional up-regulation of 25-hydroxyvitamin D 1α-hydroxylase (CYP27B1) gene is associated with the pathogenesis of ectopic calcification in the alpha klotho mutant mice (2010)
  • Author(s): Otani A
  • Organizer: American Society of Nephrology Renal Week 2010
  • Place of Presentation: Denver, CO, USA
• [Presentation] パラチノースとオレイン酸の組合せ食による肥満モデルラットの糖・脂質代謝異常抑制効果 (2010)
  • Author(s): 山本浩範
  • Organizer: 第41回日本消化吸収学会総会・第18回日本消化器関連学会(JDDW2010)
  • Place of Presentation: 横浜