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Relation between epigenetic regulation by postprandial hyperglycemia and development of metabolic diseases

Research Project

Project/Area Number 22680054
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionUniversity of Yamanashi (2011-2013)
University of Shizuoka (2010)

Principal Investigator

MOCHIZUKI Kazuki  山梨大学, 医学工学総合研究部, 准教授 (80423838)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2010: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Keywordsエピゲノム / 転写伸長 / Brd4 / 糖応答遺伝子 / 食習慣 / インスリン抵抗性 / FABP4 / 肥満 / 糖尿病 / Brd4ヘテロ欠損マウス / 脂肪細胞 / 小腸 / 食後高血糖 / 代謝性疾患 / エピジェネティックメモリー / Brd4-P-TEFb / p32
Research Abstract

In this study, we found the Brd4 protein as a new epigenetic factor to enhance mRNA levels by leading histone modifications induced by carbohydrate intake. The Brd4 enhances transcription by recruiting positive elongation factor b (P-TEFb) on transcribed region of carbohydrate-responsive genes such as carbohydrate digestion and absorption-related genes in the small intestine and insulin sensitivity genes in adipocytes. In addition, we found that increased Brd4 expression induces obesity, insulin resistance in mice. Furthermore, we found Brd4 target proteins in blood such as ALBP, ALT are useful biomarkers for obesity and insulin resistance in human.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (54 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (35 results) (of which Peer Reviewed: 35 results,  Open Access: 1 results) Presentation (18 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] Re-feeding rats a high-sucrose diet after 3 days of starvation enhances histone H3 acetylation in transcribed region and expression of jejunal GLUT5 gene2014

    • Author(s)
      Honma K, Masuda Y, Mochizuki K, and Goda T
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: (In press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insulin Resistance in SHR/NDmc-cp Rats Correlates with Enlarged Perivascular Adipocytes and Endothelial Cell Dysfunction in Skeletal Muscle2014

    • Author(s)
      Hariya N, Mochizuki K, Inoue S, Morioka K, Shimada M, Okuda T, Goda T
    • Journal Title

      J Nutr Sci Vitaminol

      Volume: 60(1) Pages: 52-9

    • NAID

      130003393765

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Resistant starch improves insulin resistance and reduces adipose tissue weight and CD11c expression in rat OLETF adipose tissue2014

    • Author(s)
      Harazaki T, Inoue S, Imai C, Mochizuki K, Goda T
    • Journal Title

      Nutrition

      Volume: 30(5) Pages: 590-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histone code of genes induced by co-treatment with a glucocorticoid hormone agonist and a p44/42 MAPK inhibitor in human small intestinal Caco-2 cells2014

    • Author(s)
      Inamochi Y, Mochizuki K, Goda T
    • Journal Title

      Biochim. Biophys. Acta

      Volume: 1840(1) Pages: 693-700

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] nsulin Resistance in SHR/NDmc-cp Rats Correlates with Enlarged Perivascular Adipocytes and Endothelial Cell Dysfunction in Skeletal Muscle.2014

    • Author(s)
      1. Hariya N, Mochizuki K, Inoue S, Morioka K, Shimada M, Okuda T, Goda T.
    • Journal Title

      J Nutr Sci Vitaminol (Tokyo).

      Volume: 60(1) Pages: 52-59

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resistant starch improves insulin resistance and reduces adipose tissue weight and CD11c expression in rat OLETF adipose tissue.2014

    • Author(s)
      Harazaki T, Inoue S, Imai C, Mochizuki K, Goda T.
    • Journal Title

      Nutrition

      Volume: 30(5) Issue: 5 Pages: 590-595

    • DOI

      10.1016/j.nut.2013.10.020

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cotreatment with the α-glucosidase inhibitor miglitol and DPP-4 inhibitor sitagliptin improves glycemic control and reduces the expressions of CVD risk factors in type 2 diabetic Japanese patients.2014

    • Author(s)
      Imai C, Saito M, Mochizuki K, Fuchigami M, Goda T, Osonoi T.
    • Journal Title

      Metabolism.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-reported faster eating associated with higher ALT activity in middle-aged, apparently healthy Japanese women.2014

    • Author(s)
      Mochizuki K, Hariya N, Miyauchi R, Misaki Y, Ichikawa Y, Goda T.
    • Journal Title

      Nutrition

      Volume: 30(1) Pages: 69-74

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Self-reported faster eating is positively associated with accumulation of visceral fat in middle-aged apparently healthy Japanese men.2014

    • Author(s)
      Mochizuki K, Yamada M, Miyauchi R, Misaki Y, Kasezawa N, Tohyama K, Goda T.
    • Journal Title

      Eur J Nutr.

      Volume: 印刷中

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fructose force-feeding induces histone H3 and H4 acetylation at their lysine residues around the Slc2a5 gene and induces its expression in mice2013

    • Author(s)
      Honma K, Mochizuki K, and Goda T
    • Journal Title

      Biosci. Biotechnol. Biochem

      Volume: (In press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methylation of histone H3 at lysine 4 and expression of the maltase-glucoamylase gene are reduced by dietary resistant starch2013

    • Author(s)
      Shimada M, Mochizuki K., Goda T
    • Journal Title

      J Nutr Biochem

      Volume: 24(3) Pages: 606-12

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dietary supplementation with a low dose of (-)-epigallocatechin-3-gallate reduces pro-inflammatory responses in peripheral leukocytes of non-obese type 2 diabetic GK rats.2013

    • Author(s)
      Uchiyama Y, Suzuki T, Mochizuki K, Goda T.
    • Journal Title

      J Nutr Sci Vitaminol (Tokyo)

      Volume: 59(6) Pages: 541-547

    • NAID

      130003393751

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating interleukin-1β concentrations are independently-positively associated with γ-glutamyltransferase activity within the normal range in middle-aged apparently healthy Japanese women.2013

    • Author(s)
      Yamazaki J, Mochizuki K, Miyauchi R, Ichikawa Y, Goda T.
    • Journal Title

      J Nutr Sci Vitaminol (Tokyo)

      Volume: 59(6) Pages: 526-532

    • NAID

      130003393749

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma sE-selectin level is positively correlated with neutrophil count and diastolic blood pressure in Japanese men.2013

    • Author(s)
      Mochizuki K, Inoue S, Miyauchi R, Misaki Y, Shimada M, Kasezawa N, Tohyama K, Goda T.
    • Journal Title

      J Nutr Sci Vitaminol (Tokyo)

      Volume: 59(5) Pages: 447-53

    • NAID

      130003393738

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dietary supplementation with (-)-epigallocatechin-3-gallate reduces inflammatory response in adipose tissue of non-obese type 2 diabetic Goto-Kakizaki (GK) rats.2013

    • Author(s)
      Uchiyama Y, Suzuki T, Mochizuki K, Goda T.
    • Journal Title

      J Agric Food Chem.

      Volume: 61(47) Pages: 11410-11417

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of postprandial hyperglycemia by either an insulin-dependent or -independent drug reduces the expression of genes related to inflammation in peripheral leukocytes of OLETF rats.2013

    • Author(s)
      Imai C, Harazaki T, Inoue S, Mochizuki K, Goda T.
    • Journal Title

      Biosci Biotechnol Biochem.

      Volume: 77(11) Pages: 2305-2308

    • NAID

      130003381925

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fructose force-feeding induces histone H3 and H4 acetylation at their lysine residues around the Slc2a5 gene and induces its expression in mice2013

    • Author(s)
      Honma K, Mochizuki K, and Goda T.
    • Journal Title

      Biosci. Biotechnol. Biochem.

      Volume: 77(11) Pages: 2188-91

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone code of genes induced by co-treatment with a glucocorticoid hormone agonist and a p44/42 MAPK inhibitor in human small intestinal Caco-2 cells.2013

    • Author(s)
      Inamochi Y, Mochizuki K, Goda T
    • Journal Title

      Biochim. Biophys. Acta.

      Volume: 1840(1) Issue: 1 Pages: 693-700

    • DOI

      10.1016/j.bbagen.2013.10.026

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methylation of histone H3 at lysine 4 and expression of the maltase-glucoamylase gene are reduced by dietary resistant starch.2013

    • Author(s)
      Shimada M, Mochizuki K, Goda T.
    • Journal Title

      J Nutr Biochem.

      Volume: 24(3) Issue: 3 Pages: 606-12

    • DOI

      10.1016/j.jnutbio.2012.03.006

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Principal component 1 score calculated from metabolic syndrome diagnostic parameters is a possible marker for the development of metabolic syndrome in middle-aged Japanese men without treatment for metabolic diseases.2013

    • Author(s)
      Mochizuki K, Miyauchi R, Misaki Y, Ichikawa Y, Goda T.
    • Journal Title

      Eur. J. Nutr.

      Volume: 52(1) Issue: 1 Pages: 67-74

    • DOI

      10.1007/s00394-011-0287-z

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of the BCMO1 gene during the suckling-weaning transition in rats is associated with histone H3 K4 methylation and subsequent coactivator binding and histone H3 acetylation to the gene2012

    • Author(s)
      Mochizuki, H., Mochizuki K, , Suruga, K., Igarashi, M., Takase, S., Goda, T
    • Journal Title

      J Nutr Sci Vitaminol (Tokyo)

      Volume: 58(5) Pages: 319-26

    • NAID

      130003368123

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trimethylation of histone H3K4 is associated with the induction of fructose-inducible genes in rat jejunum2012

    • Author(s)
      Yoshinaga, Y., Mochizuki, K., Goda, T
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 419(4) Pages: 605-11

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Induction of the BCMO1 gene during the suckling-weaning transition in rats is associated with histone H3 K4 methylation and subsequent coactivator binding and histone H3 acetylation to the gene2012

    • Author(s)
      Mochizuki, H, Mochizuki, K., Suruga, K., Igarashi, M., Takase, S., Goda, T
    • Journal Title

      J. Nutr. Sci. Vitaminol.

      Volume: 58(5) Pages: 319-26

    • NAID

      130003368123

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trimethylation of histone H3K4 is associated with the induction of fructose-inducible genes in rat jejunum.2012

    • Author(s)
      Yoshinaga, Y., Mochizuki, K., Goda, T
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 19(4) Issue: 4 Pages: 605-11

    • DOI

      10.1016/j.bbrc.2012.02.043

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Treatment with the α-glucosidase inhibitor miglitol from the preonset stage in Otsuka Long-Evans Tokushima Fatty rats improves glycemic control and reduces the expression of inflammatory cytokine genes in peripheral leukocytes2011

    • Author(s)
      Mochizuki, K., Fukaya, N., Tanaka, Y., Fuchigami, M., Goda, T
    • Journal Title

      Metabolism

      Volume: 60(11) Pages: 1560-5

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clock genes regulate the feeding schedule-dependent diurnal rhythm changes in hexose transporter gene expressions through the binding of BMAL1 to the promoter/enhancer and transcribed regions2011

    • Author(s)
      Iwashina, I., Mochizuki, K., Inamochi, Y., Goda, T
    • Journal Title

      J. Nutr. Biochem

      Volume: 22(4) Pages: 334-43

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone acetylation and binding of GCN5 on the genes2011

    • Author(s)
      Inoue, S., Mochizuki, K., Goda, T
    • Journal Title

      J. Nutr. Sci. Vitaminol

      Volume: 57(2) Pages: 162-9

    • NAID

      10030028908

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Feeding rats dietary resistant starch reduces both the binding of ChREBP and the acetylation of histones on the Thrsp Gene in the Jejunum2011

    • Author(s)
      Shimada, M., Mochizuki, K., Goda, T
    • Journal Title

      J. Agric. Food. Chem

      Volume: 59(4) Pages: 1464-9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice2011

    • Author(s)
      Fujimoto, S., Goda, T., Mochizuki, K
    • Journal Title

      Biochem. Biophys. Res. Commun

      Volume: 404(1) Pages: 223-7

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diet-induced epigenetic regulation in vivo of the intestinal fructose transporter GLUT5 during development of rat small intestine.2011

    • Author(s)
      Suzuki, T., Douard, V., Mochizuki, K., Goda, T., Ferraris, R.
    • Journal Title

      Biochem J.

      Volume: 435 Pages: 43-53

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Jejunal induction of SI and SGLT1 genes in rats by high-starch/low-fat diet is associated with histone acetylation and binding of GCN5 on the genes.2011

    • Author(s)
      Inoue, S., Mochizuki, K., Goda, T.
    • Journal Title

      J.Nutr.Sci.Vitaminol.

      Volume: (印刷中)

    • NAID

      10030028908

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feeding rats dietary resistant starch reduces both the binding of ChREBP and the acetylation of histones on the Thrsp Gene in the Jejunum.2011

    • Author(s)
      Shimada, M., Mochizuki, K., Goda, T.
    • Journal Title

      J.Nutr.Sci.Vitaminol.

      Volume: 59 Pages: 1464-1469

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] In vivo evidence of enhanced di-methylation of histone H3 K4 on upregulated genes in adipose tissue of diabetic db/db mice.2011

    • Author(s)
      Fujimoto, S., Goda, T., Mochizuki, K
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 404 Pages: 223-227

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The regulation of jejunal induction of the maltase-glucoamylase gene by a high starch/low fat-diet in mice.2010

    • Author(s)
      Mochizuki, K., Honma, K., Shimada, M., Goda, T.
    • Journal Title

      Mol.Nutr.Food Res.

      Volume: 54(10) Pages: 1445-1451

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression.2010

    • Author(s)
      Inamochi, Y., Mochizuki, K., Osaki, A., Ishii, T., Nakayama, T., Goda, T.
    • Journal Title

      Biochem.Biophys.Res.Commun.

      Volume: 392(1) Pages: 16-21

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 栄養とエピゲノム2013

    • Author(s)
      望月和樹
    • Organizer
      第67回日本栄養・食糧学会大会
    • Related Report
      2013 Final Research Report
  • [Presentation] 栄養による遺伝子のエピジェネティクス変化2013

    • Author(s)
      望月和樹
    • Organizer
      第2回DOHaD 研究会
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Presentation] 小腸における栄養シグナルにおけるブロモドメインタンパク質の役割2013

    • Author(s)
      望月和樹, 本間一江, 合田敏尚
    • Organizer
      第86回日本生化学会大会
    • Related Report
      2013 Final Research Report
  • [Presentation] 栄養とエピゲノム2013

    • Author(s)
      望月和樹
    • Organizer
      第67 回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学(名古屋)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 小腸における栄養シグナルにおけるブロモドメインタンパク質の役割2013

    • Author(s)
      望月和樹、本間一江、合田敏尚
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] エピゲノム制御因子Brd4 による脂肪細胞における脂肪蓄積の制御と出生後の発育との関連2013

    • Author(s)
      山田真実、望月和樹、合田敏尚
    • Organizer
      第2回日本DOHaD研究会
    • Place of Presentation
      厚生労働省戸山研究庁舎 (東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨格筋における異所性脂肪細胞の特徴とインスリン抵抗性との関連2013

    • Author(s)
      針谷 夏代、合田 敏尚、望月 和樹
    • Organizer
      第67 回日本栄養・食糧学会大会
    • Place of Presentation
      名古屋大学(名古屋)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ラットにおける離乳期の食事制限が成熟後の糖・脂質代謝に与える影響2013

    • Author(s)
      望月和樹、池田美沙、合田敏尚
    • Organizer
      日本農芸化学会2013年度大会
    • Place of Presentation
      東北大学(仙台)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脂肪細胞における脂肪蓄積におよぼすブロモドメインたんぱく質Brd4役割2012

    • Author(s)
      山田 真実、望月 和樹、合田 敏尚
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス脂肪組織における時計遺伝子の発現リズムの高脂肪・高スクロース食摂取による低下2012

    • Author(s)
      彦坂真希、望月和樹、合田 敏尚
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多能性骨格筋幹細胞Hu5/E18の脂肪細胞への分化における転写因子FOXO1の関与2012

    • Author(s)
      針谷 夏代、合田 敏尚、望月 和樹
    • Organizer
      第85回日本生化学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 小腸様細胞株Caco-2における分化関連遺伝子のヒストンコードによる発現誘導機構2010

    • Author(s)
      稲用裕子, 望月和樹, 合田敏尚
    • Organizer
      Biochemistry and Molecular biology2010
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] フルクトース摂取時に増大する小腸糖質輸送担体GLUT5遺伝子発現のヒストンテールの翻訳後修飾を介した調節2010

    • Author(s)
      吉永祐美子, 望月和樹, 合田敏尚
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖質摂取時に増大する小腸糖質消化吸収関連遺伝子発現のヒストンテール翻訳後修飾を介した調節機構2010

    • Author(s)
      井上聖哉, 望月和樹, 合田敏尚
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 糖質の量ならびに質がマルターゼ・グルコアミラーゼ遺伝子上のヒストン翻訳後修飾に及ぼす影響2010

    • Author(s)
      島田昌也, 望月和樹, 本間一江, 合田敏尚
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 小腸様細胞株Caco-2の分化に伴うGLUT5遺伝子発現増大におけるヒストンH3K4のメチル化の役割2010

    • Author(s)
      稲用裕子, 望月和樹, 大崎愛弓, 合田敏尚
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      米子
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒストンコードとmRNA伸長因子を介した小腸消化吸収関連遺伝子発現の日内リズム発振機構2010

    • Author(s)
      山内浩之, 望月和樹, 合田敏尚
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒストンテール翻訳後修飾を介した小腸消化吸収遺伝子の転写制御2010

    • Author(s)
      井上聖哉, 望月和樹, 合田敏尚
    • Organizer
      第4回日本エピジェネティック研究会
    • Place of Presentation
      米子
    • Related Report
      2010 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.fp.yamanashi.ac.jp/fdn/

    • Related Report
      2013 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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