Identification of novel tyrosine kinase fusion genes using a unique system based on morphology
| Project/Area Number |
22680063
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor diagnosis
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
TAKEUCHI Kengo 公益財団法人がん研究会, がん研究所病理部, 主任研究員 (40323612)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | がん / チロシンキナーゼ / 融合遺伝子 / IRF4 / ALK / ROS1 / RET / SQSTM1-ALK / PPFIBP1-ALK |
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| Research Abstract |
We identified PPFIBP1-ALK in inflammatory myofibroblastic tumor and TPM3-ALK and EML4-ALK in renal cell carcinoma. In lymphoma, we found SQSTM1-ALK. KLC1-ALK was identified from a formalin-fixed paraffin-embedded (FFPE) tissue by RACE optimized for FFPE. We established a unique system for identification of fusion genes based on histopathological methods, and identified 4 ROS1 and 2 RET novel fusion genes. We also proposed a new entity of low-grade B-cell lymphoma, which was characterized by IRF4 rearrangement
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Report
(4 results)
Research Products
(60 results)
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[Journal Article]2012
Author(s)
Soda M, Isobe K, Inoue A, Maemondo M,Oizumi S, Fujita Y, Gemma A, Yamashita Y,Ueno T, Takeuchi K, Choi YL, Miyazawa H,Tanaka T, Hagiwara K, Mano H
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Journal Title
Clin Cancer Res
Volume: 18
Issue: 20
Pages: 5682-5689
DOI
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Peer Reviewed
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[Presentation] 融合遺伝子の発見2012
Author(s)
竹内賢吾
Organizer
第10回日本臨床腫瘍学会学術集会
Place of Presentation
大阪国際会議場
Year and Date
2012-07-26
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[Presentation] 融合遺伝子の発見
Author(s)
竹内 賢吾
Organizer
第10回日本臨床腫瘍学会学術集会
Place of Presentation
大阪国際会議場
Related Report
Invited
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