Functionalized conducting polymer biointerfaces for cell engineering: specific adhesion of proteins and cells, cell patterning, and dynamic binding/releasing by electrical stimuli.

• Project/Area Number: 22681016
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Nanomaterials/Nanobioscience
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YU Hsiao-hua 独立行政法人理化学研究所, Yu 独立主幹研究ユニット, ユニットリーダー(独立主幹研究員) (70529908)
• Research Collaborator: TSENG Hsian-rong University of California, Los Angeles, Department of Molecular and Medical Pharmacology, Professor,
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000); Fiscal Year 2012: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2010: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
• Keywords: 有機化学 / 導電性高分子 / 有機導体 / バイオテクノロジー / バイオインターフェイス / ナノバイオ / ナノ材料

Research Abstract

During the 3-year of this original project, we have successfully achieved all the original goals and build a new concept to utilize molecularly designed conducting polymer to control cellular behavior on the interface between cells and materials. The interface is also dynamic therefore we can control the interface by both chemical and electrical stimulation. The major achievements include: (1) Successfully build a monomer library consists of more than 20 new thiophene based monomers. (2) Control the cellular interaction with the materials with introduction of the monomers that prohibit proteins and cells binding to the materials. (3) Switch the surface properties from layered polythiophenes assemblies. (4) Cell patterning with top-down fabrication of bottom-up electropolymerization assemblies. (5) Dynamic polythiophene-cell interface with electrical stimulation. We further studied the effect of chemical and electrical stimulation on the cell engineering with these materials. The major results include: (1) Conducting polymer nano-networks for cell engineering. Thiophene monomer with a variety of functional groups would form EDOT nano-networks with the nanofiber dimensions between 20 to 40 nm by controlling the electropolymerization kinetics. (2) Enhanced cell-capturing on the nanostructured conducting polymer with capture agents. More efficient capturing of cancer cells were demonstrated on antibody conjugated polythiophene nanodots.

Research Products

• [Journal Article] (2013)
  • Author(s): Zhao, H.; Zhu, B.; Luo, S.-C.; Lin, H.-A.; Nakao, A.; Yamashita, Y.; Yu, Hsiao-hua
  • Journal Title: ACS Appl. Mater. Interfaces Volume: (referred) Issue: 11 Pages: 4536-4543
  • DOI: 10.1021/am400135c
  • Peer Reviewed
• [Journal Article] (2013)
  • Author(s): Lin, H.-A.; Luo, S.-C.; Zhu, B.; Yamashita, Y.; Yu, Hsiao-hua
  • Journal Title: Adv. Funct. Mater. Volume: 25(referred) Issue: 25 Pages: 3212-3219
  • DOI: 10.1002/adfm.201203006
  • Peer Reviewed
• [Journal Article] (2013)
  • Author(s): Hou, S.; Zhao, H.; Zhao, L.; Shen, Q.; Wei, K. S.; Suh D. Y.; Nakao, A.; Xiong B.; Luo, S.-C.; Tseng, H.-R.; Yu, Hsiao-hua
  • Journal Title: Adv. Mater. Volume: 25 Pages: 1547-1551
  • Peer Reviewed
• [Journal Article] Capture and stimulated release of circulating tumor cells on polymer grafted silicon nanostructures (2013)
  • Author(s): Hou Shuang
  • Journal Title: Advanced Materials Volume: 25 Issue: 11 Pages: 1547-1551
  • DOI: 10.1002/adma.201203185
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Zhao, H.; Liu, C.-H.; Luo, S.-C.; Zhu, B.; Wang, T.-H.; Hsu, H.-F.; Yu, Hsiao-hua
  • Journal Title: Macromolecules Volume: 45 Pages: 7783-7790
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Luo, S.-C.; Zhu, B.; Kantchev, E. A. B.; Siang, Y. W.; Yu, Hsiao-hua
  • Journal Title: Chem. Commun. Volume: 48 Pages: 6942-6944
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Lacher, S.; Obata, N.; Luo, S.-C.; Matsuo, Y.; Zhu, B.; Yu, Hsiao-hua; Nakamura, E
  • Journal Title: ACS Appl. Mater. Interfaces Volume: 4 Pages: 3396-3404
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Luo, S.-C.; Sekine, J.; Zhu, B.; Zhao, H.; Nakao, A.; Yu, Hsiao-hua
  • Journal Title: ACS Nano Volume: 6 Pages: 3018-3026
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Zhao, H.; Zhu, B.; Sekine, J.; Luo, S.-C.; Yu, Hsiao-hua
  • Journal Title: ACS Appl. Mater. Interfaces Volume: 4 Pages: 680-686
  • Peer Reviewed
• [Journal Article] (2012)
  • Author(s): Guo, Z.; Hu, L.; Yu, Hsiao-hua; Can, X.; Gu, H.
  • Journal Title: RSC Advances Volume: 2 Pages: 3477-3480
  • Peer Reviewed
• [Journal Article] Polydioxythiophene nanodots, nanotubes, nanowires and nano-networks by template-free electropolymerization – the effect of functional groups and temperature (2012)
  • Author(s): Shyh-Chyang Luo
  • Journal Title: ACS Nano Volume: 6 Issue: 4 Pages: 3018-3026
  • DOI: 10.1021/nn300737e
  • Peer Reviewed
• [Journal Article] Electropolymerized Conjugated Polyelectrolytes with Tunable Work Function and Hydrophobicity as an Anode Buffer in Organic Optoelectronics (2012)
  • Author(s): S. Lacher, N. Obata, S.-C. Luo, Y. Matsuo, B. Zhu, H.-H. Yu, E. Nakamura
  • Journal Title: ACS Appl. Mater. Interfaces Volume: 4 Issue: 7 Pages: 3396-3404
  • DOI: 10.1021/am300366d
  • Peer Reviewed
• [Journal Article] Facile syntheses of dioxythiophene-based conjugated polymers by direct C-H arylation (2012)
  • Author(s): Haichao Zhao
  • Journal Title: Macromolecules Volume: 45 Issue: 19 Pages: 7783-7790
  • DOI: 10.1021/ma300719n
  • Peer Reviewed
• [Journal Article] Tunable, dynamic and electrically stimulated lectin-carbohydrate recognition on a glycan-grafted conjugated polymer (2012)
  • Author(s): Shyh-Chyang Luo
  • Journal Title: Chemical Communications Volume: 48 Issue: 55 Pages: 6942-6944
  • DOI: 10.1039/c2cc31789c
  • Peer Reviewed
• [Journal Article] Controlled hydrogenation of aromatic compounds by platinum nanowire catalysts (2012)
  • Author(s): Zhiqiang Guo
  • Journal Title: RSC Advances Volume: 2 Issue: 8 Pages: 3477-3480
  • DOI: 10.1039/c2ra01097f
  • Peer Reviewed
• [Journal Article] Oligoethylene glycol functionalized polyoxythiophenes for cell engineering : syntheses, characterizations and cell compatibilities (2012)
  • Author(s): Zhao, H.; Zhu, B.; Sekine, J.; Luo, S.-C.; Yu, Hsiao-hua
  • Journal Title: ACS Applied Materials and Interfaces Volume: 4 Issue: 2 Pages: 680-686
  • DOI: 10.1021/am2012905
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Pardilla, J. A.; Otero, T. F.; Yu, Hsiao-hua
  • Journal Title: Electrochimica Acta Volume: 56 Pages: 10238-10245
• [Journal Article] (2011)
  • Author(s): Sekine, J.; Luo, S.-C.; Wang, S.; Zhu, B.; Tseng, H.R.; Yu, Hsiao-hua
  • Journal Title: Adv. Mater Volume: 23 Pages: 4788-4792
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Liu, C.-Y.; Zhao, H.; Yu, Hsiao-hua
  • Journal Title: Org. Lett. Volume: 13 Pages: 4068-4071
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Luo, S.-C.; Zhu, B.; Nakao, A.; Nakatomi, R.; Yu, Hsiao-hua
  • Journal Title: Adv. Eng. Mater. (Advanced Biomaterials) Volume: 13
  • Peer Reviewed
• [Journal Article] (2011)
  • Author(s): Tansil, N. C.; Kantchev, E. A. B.; Gao, Z.; Yu, Hsiao-hua
  • Journal Title: Chem. Commun. Volume: 47 Pages: 1533-1535
  • Peer Reviewed
• [Journal Article] Functionalized conducting polymer nano-networks from controlled oxidation polymerization toward cell engineering (2011)
  • Author(s): Luo, S.-C.; Zhu, B.; Nakao, A.; Nakatomi, R.; Yu, Hsiao-hua
  • Journal Title: Advanced Engineering Materials (Advanced Biomaterials) Volume: 13 Issue: 10
  • DOI: 10.1002/adem.201080109
  • Peer Reviewed
• [Journal Article] Electropolymerization and characterization of COOH-functionalized poly(3,4-ethylenedioxythiophene) : ionic exchanges (2011)
  • Author(s): Arias-Pardilla, J.; Otero, T.F.; Yu, Hsiao-hua
  • Journal Title: Electrochimica Acta Volume: 56 Issue: 27 Pages: 10238-10245
  • DOI: 10.1016/j.electacta.2011.09.020
  • Peer Reviewed
• [Journal Article] Functionalized conducting polymer nanodots for enhanced cell capturing : the synergistic effect of capture agents and nanostructures (2011)
  • Author(s): Sekine, J.; Luo, S.-C; Wang, S.; Zhu, B.; Tseng, H.-R.; Yu, Hsiao-hua
  • Journal Title: Advanced Materials Volume: 23 Issue: 41 Pages: 4788-4792
  • DOI: 10.1002/adma.201102151
  • Peer Reviewed
• [Journal Article] Efficient synthesis of 3,4-Ethylenedioxythiophene (EDOT)-based functional Π-conjugated molecules through direct C-H bond arylations (2011)
  • Author(s): Liu, C.-Y.; Zhao, H.; Yu, Hsiao-hua
  • Journal Title: Organic Letters Volume: 13 Issue: 15 Pages: 4068-4071
  • DOI: 10.1021/ol201571u
  • Peer Reviewed
• [Journal Article] Electropolymerization of intercalator-grafted conducting polymer for direct and amplified DNA detection (2011)
  • Author(s): Tansil Natalia, Kantchev Eric, Gao Zhiqiang, Yu Hsiao-hua
  • Journal Title: Chemical Communications Volume: 47 Pages: 1533-1535
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Luo, S.-C.; Liour, S. S.; Yu, Hsiao-hua
  • Journal Title: Chem. Commun. Volume: 46 Pages: 4731-4733
  • Peer Reviewed
• [Journal Article] Perfluoro-functionalized PEDOT films with controlled morphology as superhydrophobic coatings and biointerfaces with enhanced cell adhesion (2010)
  • Author(s): Luo Shyh-Chyang, Liour Sean, Yu Hsiao-hua
  • Journal Title: Chemical Communications Volume: 46 Pages: 4731-4733
  • Peer Reviewed
• [Presentation] A Biomimetic Approach for Conducting Polymer-based Cell Engineering (2013)
  • Author(s): Hsiao-hua Yu
  • Organizer: 4th Taiwan-Japan Nanomedicine Meeting
  • Place of Presentation: Academia Sinica, Taipei, Taiwan
  • Invited
• [Presentation] Organic Conductive Biomaterials: from E (2013)
  • Author(s): Hsiao-hua Yu
  • Organizer: Seminar at Department of Chemicals and Materials Engineering, National Central University
  • Place of Presentation: Jhongli City, Taiwan
  • Invited
• [Presentation] Nanomaterials for E (2013)
  • Author(s): Hsiao-hua Yu
  • Organizer: 2nd International Conference on Biomaterials Science in Tsukuba (ICBS2013)
  • Place of Presentation: Tsukuba
• [Presentation] Organic Conductive Biomaterials: Syntheses, Assemblies, and Applications (2013)
  • Author(s): Hsiao-hua Yu
  • Organizer: Seminar at Academia Sinica
  • Place of Presentation: Taipei, Taiwan
  • Invited
• [Presentation] Soft Nanomaterials for E (2013)
  • Author(s): Hsiao-hua Yu
  • Organizer: Soft-interfaces Mini-symposium 2013 -Physical Chemistry and Characterization of Softinterfaces (SIMS2013)
  • Place of Presentation: Kyushu University, Fukuoka
  • Invited
• [Presentation] The e (2013)
  • Author(s): Jun Sekine
  • Organizer: Soft-interfaces Mini-symposium 2013 -Physical Chemistry and Characterization of Softinterfaces (SIMS2013)
  • Place of Presentation: Kyushu University, Fukuoka
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: Hanyang University
  • Place of Presentation: Seoul, Korea(招待講演)
  • Year and Date: 2012-02-13
• [Presentation] Nanoscale Structure and Electrical (2012)
  • Author(s): Jun Sekine
  • Organizer: 9thWorld Biomaterials Congress (9th WBC)
  • Place of Presentation: Chongdu, China
• [Presentation] Targetoriented and step-economical synthesis of functional-pi conjugated materials (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: 2nd International Conference on Moldecular and Functional Catalysis (ICMFC-2)
  • Place of Presentation: Singapore, Singapore
  • Invited
• [Presentation] Polydioxythiophene Nanodots, Nanowires, Nanonetworks and Tubular Structures: the Effect of Functional Groups and Temperature in Template-Free Electropolymerization (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: International Conference on Science and Technology of Synthetic Metals (ICSM 2012)
  • Place of Presentation: Atlanta, USA
• [Presentation] Functional and nanostructured conductiong polymers for cell engineering (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: 1st International Symposium on Polymer Ecomaterials
  • Place of Presentation: Changchun, China
  • Invited
• [Presentation] Functional and nanostructured conductiong polymers for cell engineering (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: 3rd Asia-Paci
  • Place of Presentation: Wollongong, Australia
  • Invited
• [Presentation] Organic Conductive Biomaterials: from Effi (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: Asian Core Program Fellowship - Singapore at IMRE
  • Place of Presentation: Singapore
  • Invited
• [Presentation] Organic Conductive Biomaterials: from Effi (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: Asian Core Program Fellowship - Singapore at Nanyang Technological University
  • Place of Presentation: Singapore
  • Invited
• [Presentation] Organic Conductive Biomaterials: from Effi (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: Asian Core Program Fellowship - Singapore at National University of Singapore
  • Place of Presentation: Singapore
  • Invited
• [Presentation] To manipulate cells behavior by electro-stimuli under conducting polymer nanointerface (2012)
  • Author(s): Jun Sekine
  • Organizer: 2012 MRS Fall Meeting and Exhibit
  • Place of Presentation: Boston, USA
• [Presentation] Functionalized pi-Conjugated Nanomaterials by Facile Synthetic and Assembling Approaches (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: Asian Core Program 2012
  • Place of Presentation: Academia Sinica, Singapore
  • Invited
• [Presentation] Functionalized pi-Conjugated Nanomaterials by Facile Synthetic and Assembling Approaches (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: The 7th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-7)
  • Place of Presentation: Nanyang Technological University, Singapore
• [Presentation] Functional and nanostructured conductiong polymers for cell engineering (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: ソフトインターフェースの分子科学ワークショップ
  • Place of Presentation: 東京医科歯科大学、東京
  • Invited
• [Presentation] Functional and nanostructured conductiong polymers for cell engineering (2012)
  • Author(s): Hsiao-hua Yu
  • Organizer: 第２９回医用高分子研究会講座
  • Place of Presentation: 産総研臨海副都心センター、東京
  • Invited
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: 北海道大学
  • Place of Presentation: 札幌日本(招待講演)
  • Year and Date: 2011-12-22
• [Presentation] Target-Oriented and atom-Economical synthesis of functional pi-conjugated molecules (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: ICCEOCA-6 and NICCEOCA-2
  • Place of Presentation: Hong Kong, China
  • Year and Date: 2011-12-12
• [Presentation] Pd-Catalyzed Direct C-H Arylations : A Simple Recipe for Challenging Functional Substrates (2011)
  • Author(s): Ching-Yuan Liu, Hsiao-hua Yu
  • Organizer: 10^<th> International Symposium on organic Reactions
  • Place of Presentation: 横浜日本
  • Year and Date: 2011-11-24
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: 京都大学GCOE-理化学研究所共同シンポジウム
  • Place of Presentation: 京都日本
  • Year and Date: 2011-11-11
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: Institute of Chemistry, Chinese Academy of Sciences
  • Place of Presentation: Beijing, China(招待講演)
  • Year and Date: 2011-10-18
• [Presentation] Conducting Polymer as Biomaterials : Control the Cell-Materials Interfaces (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: 10^<th> International Symposium on Functional pi-Electron Systems
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-10-17
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: Peking University
  • Place of Presentation: Beijing, China(招待講演)
  • Year and Date: 2011-10-17
• [Presentation] Synthesis and Properties of Polydioxythiophenes via Pd(OAc)_2 catalyzed C-H Arylation (2011)
  • Author(s): Haichao Zhao, Ching-Yuan Liu, Shyh-Chyang Luo, Bo Zhu, Hsiao-hua Yu
  • Organizer: 10^<th> International Symposium on Functional pi-Electron Systems
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-10-15
• [Presentation] All-Conducting-Polymer Interface for Neural Engineering via Biomimetic Approach (2011)
  • Author(s): Bo Zhu, Shyh-Chyang Luo, Jun Sekine, Haochao Zhao, Hsiao-hua Yu
  • Organizer: 10^<th> International Symposium on Functional pi-Electron Systems
  • Place of Presentation: Beijing, China
  • Year and Date: 2011-10-14
• [Presentation] Nanostructured PEDOT Biointerfaces for Enhanced Efficiency of Cell Capturing (2011)
  • Author(s): Shyh-Chyang Luo, Jun Sekine, Bo Zhu, Hsiao-hua Yu
  • Organizer: IUMRS-ICA2011
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2011-09-22
• [Presentation] Novel Zwitterionic Conducting Polymer with Controllable Polymer Absorption (2011)
  • Author(s): Haichao Zhao, Shyh-Chyang Luo, Hsiao-hua Yu
  • Organizer: IUMRS-ICA 2011
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2011-09-21
• [Presentation] Spatially Confined Layer-by-Layer Electrodeposition to produce Biofunction Patterning on All Conducting Polymer Substrates (2011)
  • Author(s): Bo Zhu, Shyh-Chyang Luo, Jun Sekine, Hsiao-hua Yu
  • Organizer: IUMRS-ICA 2011
  • Place of Presentation: Taipei Taiwan
  • Year and Date: 2011-09-20
• [Presentation] Target-Oriented and atom-Economical synthesis of functional pi-conjugated molecules (2011)
  • Author(s): Ching-Yuan Liu, Hsiao-hua Yu
  • Organizer: OMCOS-16
  • Place of Presentation: Shanghai, China
  • Year and Date: 2011-07-26
• [Presentation] Conducting Polymer as Biomaterials : Control the Cell-Materials Interfaces (2011)
  • Author(s): Yu Hsiao-hua
  • Organizer: China-Japan-Korea Foresight Joint Symposium
  • Place of Presentation: Guilin, China(招待講演)
  • Year and Date: 2011-05-30
• [Presentation] Conducting polymer as biomaterials: control the cell-materials interfaces (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: China-Japan-Korea Foresight Joint Symposium
  • Place of Presentation: Guilin, China
  • Year and Date: 2011-05-29
• [Presentation] Functional conducting polymer biomaterials (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪日本
  • Year and Date: 2011-05-26
• [Presentation] Bio-function patterning on all-conducting polymer substrate by spatially confined electro-deposition (2011)
  • Author(s): 朱波, 羅世強, 関根淳, Yu Hsiao-hua
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪日本
  • Year and Date: 2011-05-26
• [Presentation] Functional conducting polymer platforms for cell growth (2011)
  • Author(s): 関根淳, 朱波, 羅世強, Yu Hsiao-hua
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪日本
  • Year and Date: 2011-05-26
• [Presentation] Nanostructured PEDOT Thin films by electropolymerization-understanding the chemical structure and temperature effect (2011)
  • Author(s): 羅世強, 関根淳, 朱波, 趙海超, Yu Hsiao-hua
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪日本
  • Year and Date: 2011-05-26
• [Presentation] Synthesis of amphiphilic ethylene glycol-containing polythiophene toward novel conducting material (2011)
  • Author(s): 趙海超, Yu Hsiao-hua
  • Organizer: 第60回高分子学会年次大会
  • Place of Presentation: 大阪日本
  • Year and Date: 2011-05-26
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: University of Wollongong
  • Place of Presentation: Wollongong, Australia(招待講演)
  • Year and Date: 2011-05-18
• [Presentation] Organic conductive biomaterials: from efficient syntheses to bioengineering applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: Intelligent Polymer Research Institute, University of Wollongong
  • Place of Presentation: Wollongong, Australia
  • Year and Date: 2011-05-17
• [Presentation] Nanostructured and Functionalized Polymers for Cell Engineering (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: Biofabrication Symposium
  • Place of Presentation: Wollongong Australia(招待講演)
  • Year and Date: 2011-05-17
• [Presentation] Biomimetic conductive membranes produced via inverse microemulsionelectron-copolymerization as neural interfaces (2011)
  • Author(s): Bo Zhu, Shyh-Chyang Luo, Jun Sekine, Hsiao-hua Yu
  • Organizer: E-MRS ICAM IUMRS 2011 Spring Meeting
  • Place of Presentation: Nice, France
  • Year and Date: 2011-05-11
• [Presentation] Biomimetic conductive membranes produced via inverse microemulsionelectro-copolymerization as neural interfaces (2011)
  • Author(s): Bo Zhu, Shyh-Chyang Luo, Jun Sekine, Hsiao-hua Yu
  • Organizer: E-MRS ICAM IUMRS 2011 Spring Meeting
  • Place of Presentation: Nice, France(招待講演)
  • Year and Date: 2011-05-11
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: National Chiao-Tung University
  • Place of Presentation: Hsinchu, Taiwan(招待講演)
  • Year and Date: 2011-05-03
• [Presentation] Organic Conductive Biomaterials: from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: Soochow University
  • Place of Presentation: Suzhou, China(招待講演)
  • Year and Date: 2011-04-29
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: East China University of Science and Technology
  • Place of Presentation: Shanghai, China(招待講演)
  • Year and Date: 2011-04-27
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: Shanghai Institute of Organic Chemistry
  • Place of Presentation: Shanghai, China(招待講演)
  • Year and Date: 2011-04-26
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: Fudan University
  • Place of Presentation: Shanghai, China(招待講演)
  • Year and Date: 2011-04-25
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: Institute of Chemistry, Academia Sinica
  • Place of Presentation: Taipei, Taiwan(招待講演)
  • Year and Date: 2011-04-20
• [Presentation] Organic Conductive Biomaterials : from Efficient Syntheses to Bioengineering Applications (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: University of California, Los Angeles
  • Place of Presentation: Los Angeles, USA(招待講演)
  • Year and Date: 2011-04-14
• [Presentation] Control and Manipulate Cell Behaviors on Functionalized and Nanostructured Conducting Polymer Biomaterials (2011)
  • Author(s): Hsiao-hua Yu, Bo Zhu, Shyh-Chyang Luo, Haichao Zhao, Jun Sekine
  • Organizer: Society for Biomaterials 2011 Annual Meeting
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-04-13
• [Presentation] Organic Conductive Biomaterials for Biosensing and Cell Engineering (2011)
  • Author(s): Hsiao-hua Yu
  • Organizer: University of Florida
  • Place of Presentation: Gainesville, USA(招待講演)
  • Year and Date: 2011-04-12
• [Presentation] Protein-resistant and conductive membranes on conducting polymers (2010)
  • Author(s): Zhu Bo, Luo Shyh-Chyang, Sekine Jun, Yu Hsiao-hua
  • Organizer: International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
  • Place of Presentation: Honolulu USA
  • Year and Date: 2010-12-19
• [Presentation] Biomimicking conducting polymer for protein-resistant and specific-binding biointerace (2010)
  • Author(s): Zhu Bo, Luo Shyh-Chyang, Zhao Haichao, Yu Hsiao-hua
  • Organizer: International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2010)
  • Place of Presentation: Honolulu USA
  • Year and Date: 2010-12-18
• [Presentation] Target-oriented and atom-economical synthesis of functional pi-conjugate materials (2010)
  • Author(s): Liu Ching-Yuan, Yu Hsiao-hua
  • Organizer: 10th Tateshina Conference on Organic Chemistry
  • Place of Presentation: Tateshina Japan
  • Year and Date: 2010-11-13
• [Presentation] Nanostructured PEDOT Biointerfaces for Enhanced Circulating Tumor Cell Capturing (2010)
  • Author(s): Yu Hsiao-hua
  • Organizer: Asian Conference on Nanoscience and Nanotechnology 2010 (AsiaNANO 2010)
  • Place of Presentation: Tokyo Japan
  • Year and Date: 2010-11-02
• [Presentation] Controlled cell and biomarcomolecule adhesion on conducting polymer biointerfaces (2010)
  • Author(s): Luo Shyh-Chyang
  • Organizer: Gordon Research Conferences on Biointerface Science
  • Place of Presentation: Les Diablerets Switzerland
  • Year and Date: 2010-09-06
• [Presentation] Conducting polymer nanobiointerfaces for biosensing and cell engineering (2010)
  • Author(s): Yu Hsiao-hua, Luo Shyh-Chyang, Zhu Bo, Sekine Jun
  • Organizer: 10th IEEE International Cnference on Nanotechnology
  • Place of Presentation: Goyang Korea
  • Year and Date: 2010-08-20
• [Presentation] Conducting Polymer Nanobiointerfaces for Biosensing and cell Engineering (2010)
  • Author(s): Yu Hsiao-hua
  • Organizer: Seoul National University
  • Place of Presentation: Seoul Korea
  • Year and Date: 2010-08-19
• [Presentation] Conducting polymer biointerface for biosensing and cell engineering (2010)
  • Author(s): Hsiao-hua Yu
  • Organizer: IEEE Nano 2010 and Nano Korea 2010, TS6 "Nano-Sensors and Nano Membranes"
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2010-08-18
• [Presentation] Biomimic Conductive Membrane toward Protein Resistant Biointerace (2010)
  • Author(s): Zhu Bo
  • Organizer: International Conference on Science and Technology of Synthetic Metals (ICSM 2010)
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2010-07-04
• [Presentation] Reversible concanavalin a binding on mannose-functionalized PEDOT biointerface (2010)
  • Author(s): Luo Shyh-Chyang
  • Organizer: International Conference on Science and Technology of Synthetic Metals (ICSM 2010)
  • Place of Presentation: Kyoto Japan
  • Year and Date: 2010-07-04
• [Presentation] Controlling cell and biomacromolecule adhesion on conducting polymer interface (2010)
  • Author(s): Hsiao-hua Yu
  • Organizer: E-MRS 2010 Spring Meeting, Symposium B "Functional Bioniterfaces
  • Place of Presentation: Strasbourg, France
  • Year and Date: 2010-06-08
• [Presentation] Controlling cell and biomacromolecule adhesion on conducting polymer biointerface (2010)
  • Author(s): Yu Hsiao-hua
  • Organizer: E-MRS 2010 spring meeting
  • Place of Presentation: Strasbourg, France
  • Year and Date: 2010-06-07
• [Presentation] ポリチオフェン薄膜の表面構造が細胞接着性に及ぼす影響 (2010)
  • Author(s): 関根淳, 羅世強, 朱波, Yu Hsiao-hua
  • Organizer: 第59回高分子学会年次大会
  • Place of Presentation: 横浜 日本
  • Year and Date: 2010-05-28
• [Presentation] Development of zwitterionic conducting polymer with controllable pretein absorption (2010)
  • Author(s): 趙海超, 羅世強, 朱波, Yu Hsiao-hua
  • Organizer: 第59回高分子学会年次大会
  • Place of Presentation: 横浜 日本
  • Year and Date: 2010-05-27
• [Presentation] Controlling cell and biomacromolecule adhesion on conducting polymer thin films (2010)
  • Author(s): Yu Hsiao-hua, 羅世強, 朱波, 関根淳
  • Organizer: 第59回高分子学会年次大会
  • Place of Presentation: 横浜 日本
  • Year and Date: 2010-05-27
• [Presentation] Biomimic conductive polymer toward antifouling nano-biointerace (2010)
  • Author(s): 朱波, 羅世強, Yu Hsiao-hua
  • Organizer: 第59回高分子学会年次大会
  • Place of Presentation: 横浜 日本
  • Year and Date: 2010-05-27
• [Presentation] General approach for bulk synthesis of 1-D functionalized PEDOT nanostructures (2010)
  • Author(s): 羅世強, 朱波, 関根淳, 趙海超, Yu Hsiao-hua
  • Organizer: 第59回高分子学会年次大会
  • Place of Presentation: 横浜 日本
  • Year and Date: 2010-05-27
• [Book] PEDOTの材料物性とデバイス応用 (2012)
  • Author(s): 関根淳, Hsiao-hua Yu
  • Publisher: サイエンス&テクノロジー
• [Remarks] 血中のがん細胞を高感度でキャッチ＆リリースできるナノデバイスを開発
  • URL: http://www.riken.go.jp/pr/press/2012/20121225/
• [Remarks]
  • URL: http://www.riken.jp/lab/yuiru/