| Budget Amount *help |
¥23,140,000 (Direct Cost: ¥17,800,000、Indirect Cost: ¥5,340,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2010: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Research Abstract |
New method for synthesizing benzo-annulated heterocycles such as coumarins and acridanes based on the highly electrophilic character of arynes has been developed. The key intermediates in these reactions are ortho-quinoid species (ortho-quinone methide, ortho-azaxylylene) arising from formal [2+2] cycloaddition between arynes and carbon-heteroatom double bonds (dimethylformamide, imine). Subsequent [4+2] cycloaddition between the resulting ortho-quinoid species and ester enolates or second arynes provides the final products.
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