| Budget Amount *help |
¥25,740,000 (Direct Cost: ¥19,800,000、Indirect Cost: ¥5,940,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2010: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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| Research Abstract |
Human norovirus is one of the leading causes of infectious gastroenteritis worldwide. Infections of human noroviruses are not controllable, and there are no effective prevention measures. In this study, I hypothesized that there are some enteric bacteria which can specifically capture norovirus particles through HBGA-like substances. As a result, I successfully isolated an enteric bacterial strain, Enterobacter sp. SENG-6, as an HBGA-positive bacteria. The binding between this strain and norovirus-like particles (NoVLPs) were confirmed by transmission electron microscopy (TEM). I also confirmed that Enterobacter sp. SENG-6 is excreting A-like substances as extracellular polymeric substances. These results revealed that HBGA-positive bacteria can affect the fate of human noroviruses by capturing via HBGA-like substances.
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