Structural Studies on Auto-regulatory Mechanism of Cyanobacterial Clock Proteins
| Project/Area Number |
22687010
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics
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| Research Institution | Institute for Molecular Science (2012)
Nagoya University (2010-2011) |
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Principal Investigator |
AKIYAMA Shuji 分子科学研究所, 生命・錯体分子科学研究領域, 教授 (50391842)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2012: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2011: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2010: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
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| Keywords | 生物物理 / 生物時計 / 分光学 / 小角散乱 / シアノバクテリア / Ｘ線小角散乱 / 蛋白質 / 溶液散乱 / 分光計測 / 温度補償性 / 時計タンパク質 |
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| Research Abstract |
Dynamic structural change of the KaiC hexamer revealed in this study provides notable insights into the cyanobacterial circadian clock. Our model implies that KaiC ticks through expanding and contracting motions of the C2 ring. The timing of the accumulation of KaiC carrying the expanded C2 ring is coincident with that of accumulation of KaiC associated both with KaiA and KaiB. The conformational ticking of KaiC is likely to serve as a timing cue for assembly/disassembly of KaiA and KaiB.
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Report
(4 results)
Research Products
(50 results)
