| Budget Amount *help |
¥26,000,000 (Direct Cost: ¥20,000,000、Indirect Cost: ¥6,000,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2010: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
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| Research Abstract |
We have examined that the motility driven by (1) kinesins functioning in mitosis and (2)or axonemal dyneins being involved in ciliary movement. We found that kinesin-6 and outer arm dynein rotated sliding microtubules around their longitudinal axis. These corkscrewing motion of microtubule has not been observed in kinesin-6 or outer arm dynein from any source. The corkscrewing motion depends on ATP concentration in the buffer,phosphorylation on N-terminal region of kinesin-6 head, binding protein or direction of load. Our results suggested that torque generation of microtubule-based motors may be regulated by external conditions.
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