| Budget Amount *help |
¥20,410,000 (Direct Cost: ¥15,700,000、Indirect Cost: ¥4,710,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2010: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
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| Research Abstract |
Serotonin is a well-known neurotransmitter involved in sociality and/or behavior of animal. In the present study, we revealed that Tphd2, a serotonin synthesis emzyme, is expressed in the organizer in zebrafish. In addition, serotonin itself is expressed during gastrulation depending on the organizer. Inhibition of Tphd2 by antisense resulted in shortened body axis. Molecular and developmental studies demonstrated that Thpd2 is required for migration of cells toward to the dorsal region during morphogenesis. Finally, the results clearly indicate that serotonin is involved in early body patterning in zebrafish development.
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