Visualization of the neural circuit transmitting taste information and elucidation of mechanisms underlying its development and maintenance
| Project/Area Number |
22688010
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
ISHIMARU Yoshiro (2011-2012) 東京大学, 大学院・農学生命科学研究科, 特任助教 (10451840)
石丸 喜朗 (2010) 東京大学, 大学院・農学生命科学研究科, 特任助教 (10481045)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥23,270,000 (Direct Cost: ¥17,900,000、Indirect Cost: ¥5,370,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2010: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Keywords | 味覚 / 脳・神経 / 解剖学 / 酸味受容体 / シナプストレーサー / トランスジェニックマウス |
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| Research Abstract |
To elucidate the mechanism underlying the transmission of taste information from taste buds to the brain, the neural circuit transmitting sour taste information was first visualized by generating transgenic mice in which a transneuronal tracer, wheat germ agglutinin, was specifically expressed in sour-sensing cells. It has been suggested that the neural circuits transmitting pleasant (sweet and umami) and aversive (bitter and sour) tastes were mutually segregated in the cranial sensory ganglia.
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Report
(4 results)
Research Products
(61 results)
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[Journal Article] Characterization of the beta-D-gluco- pyranoside binding site of the human bitter taste receptor hTAS2R162010
Author(s)
Sakurai T, Misaka T, Ishiguro M, Masuda K, Sugawara T, Ito K, Kobayashi T, Matsuo S, Ishimaru Y, Asakura T, Abe K
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Journal Title
J. Biol. Chem
Volume: 285巻
Issue: 36
Pages: 28373-28378
DOI
Related Report
Peer Reviewed
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