Investigation of the pathophysiological role of an anti-inflammatory mediator prostaglandin D2.

• Project/Area Number: 22688024
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Basic veterinary science/Basic zootechnical science
• Research Institution: The University of Tokyo
• Principal Investigator: MURATA Takahisa 東京大学, 農学生命科学研究科, 准教授 (40422365)
• Project Period (FY): 2010-04-01 – 2013-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000); Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000); Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000); Fiscal Year 2010: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
• Keywords: 薬理 / 炎症 / 病態 / 組織再生 / 薬理学 / 獣医学 / 癌 / 肥満細胞 / プロスタグランジン / 血管新生

Research Abstract

We here investigated the pathophysiological role of an anti-inflammatory mediator prostaglandin D2. We found that 1) integral membrane protein Caveolin-1 modulates prostaglandin synthase activity, 2) urinary metabolite of prostaglandin D2 might be biomarker of various inflammatory diseases, 3) prostaglandin D2 signal enhancement inhibit the progressions of inflammatory diseases, 4) inhibition of prostaglandin D2 synthase leads vascular and tissue regenerations. These observations provide new insights for future therapy against inflammatory diseases and tissue re-generation.

Research Products

• [Journal Article] Opposing immunomodulatory roles of prostaglandin D2 during theprogression of skin inflammation. (2014)
  • Author(s): Hana Sarashina, Yoshiki Tsubosaka, Keisuke Omori, Kosuke Aritake, Takayuki Nakagawa, Masatoshi Hori, Hiroyuki Hirai, Masataka Nakamura, Shuh Narumiya, Yoshihiro Urade, Hiroshi Ozaki and Takahisa Murata
  • Journal Title: The Journal of Immunology Volume: 192(1) Issue: 1 Pages: 459-65
  • DOI: 10.4049/jimmunol.1302080
  • Peer Reviewed / Open Access
• [Journal Article] Stimulation of G protein-coupled bile acid receptor enhances vascular endothelial barrier function via activation of protein kinase A and Rac1 (2014)
  • Author(s): Kida T, Omori K, Hori M, Ozaki H, Murata T
  • Journal Title: J Pharmacol Exp Ther Volume: 348(1) Issue: 1 Pages: 125-130
  • DOI: 10.1124/jpet.113.209288
  • Peer Reviewed / Open Access
• [Journal Article] Diverse effects of prostaglandin E2 on vascular contractility (2014)
  • Author(s): Kida T, Sawada K, Kobayashi K, Hori M, Ozaki H, Murata T
  • Journal Title: Heart Vessels Volume: 29(3) Issue: 3 Pages: 390-395
  • DOI: 10.1007/s00380-013-0374-6
  • Peer Reviewed
• [Journal Article] Diverse effects of prostaglandin E2 on vascular contractility. (2014)
  • Author(s): Kida T, Sawada K, Kobayashi K, Hori M, Ozaki H, Murata T.
  • Journal Title: Heart Vessels Volume: 印刷中
  • Peer Reviewed
• [Journal Article] PDGF and TGF-beta promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice. (2014)
  • Author(s): Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H.
  • Journal Title: British Journal of Pharmacology Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Stimulation of G Protein-coupled Bile Acid Receptor Enhances Vascular Endothelial Barrier Function via Activation of PKA and Rac1. (2014)
  • Author(s): Kida T, Omori K, Hori M, Ozaki H, Murata T.
  • Journal Title: The Journal of Pharmacology and Experimental Therapeutics. Volume: 348 Pages: 125-30
  • Peer Reviewed
• [Journal Article] Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation. (2014)
  • Author(s): Sarashina H, Tsubosaka Y, Omori K, Aritake K, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H, Murata T.
  • Journal Title: J Immunology Volume: 192 Pages: 459-65
  • Peer Reviewed
• [Journal Article] Dynamin-2 regulation of integrin endocytosis, but not VEGF signaling, is critical for developmental angiogenesis. (2014)
  • Author(s): Lee M, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano A, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood D, Ferguson S, DeCamilli P, Sessa WC.
  • Journal Title: Development Volume: 141 Pages: 1465-72
  • Peer Reviewed
• [Journal Article] UDP induces intestinal epithelial migration via the P2Y6 receptor (2013)
  • Author(s): Nakamura T, Murata T, Hori M, Ozaki H
  • Journal Title: Br J Pharmacol Volume: 170(4) Issue: 4 Pages: 883-892
  • DOI: 10.1111/bph.12334
  • Peer Reviewed / Open Access
• [Journal Article] Bile acid receptor TGR5 agonism induces NO production and reduces monocyte adhesion in vascular endothelial cells (2013)
  • Author(s): Kida T, Tsubosaka Y, Hori M, Ozaki H, Murata T
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 33(7) Issue: 7 Pages: 1663-1669
  • DOI: 10.1161/atvbaha.113.301565
  • Peer Reviewed / Open Access
• [Journal Article] Prostaglandin D2 inhibits collagen secretion from lung fibroblasts by activating the DP receptor (2013)
  • Author(s): Ayabe S, Kida T, Hori M, Ozaki H, Murata T
  • Journal Title: J Pharmacol Sci Volume: 121(4) Pages: 312-317
  • Peer Reviewed
• [Journal Article] Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement (2013)
  • Author(s): Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H
  • Journal Title: Proc Natl Acad Sci U S A Volume: 110(13) Issue: 13 Pages: 5205-5210
  • DOI: 10.1073/pnas.1218091110
  • Peer Reviewed
• [Journal Article] Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts (2013)
  • Author(s): Iwanaga K, Murata T, Hori M, Ozaki H
  • Journal Title: Eur J Pharmacol Volume: 702(1-3) Issue: 1-3 Pages: 158-164
  • DOI: 10.1016/j.ejphar.2013.01.025
  • Peer Reviewed
• [Journal Article] Prostaglandin D2-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway (2013)
  • Author(s): Kobayashi K、Tsubosaka Y, Hori M
  • Journal Title: Arteriosclerosis, Thrombosis, and Vascular Biology Volume: 33 Issue: 3 Pages: 565-571
  • DOI: 10.1161/atvbaha.112.300993
  • Peer Reviewed
• [Journal Article] Prostaglandin D2 inhibits collagen secretion from lung fibroblasts by activating DP receptor. (2013)
  • Author(s): Ayabe S, Kida T, Hori M, Ozaki H, Murata T.
  • Journal Title: Journal of Pharmacological Sciences Volume: 121 Pages: 312-317
  • Peer Reviewed
• [Journal Article] Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement. (2013)
  • Author(s): Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H.
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America. Volume: 110 Pages: 5205-10
  • Peer Reviewed
• [Journal Article] Purinergic P2Y1 receptor signaling mediates wound stimuli-induced cyclooxygenase-2 expression in intestinal subepithelial myofibroblasts. (2013)
  • Author(s): Iwanaga K, Murata T, Hori M, Ozaki H.
  • Journal Title: European Juornal of Pharmacology. Volume: 702 Pages: 158-164
  • Peer Reviewed
• [Journal Article] Prostaglandin D2-DP Signaling Promotes Endothelial Barrier Function via the cAMP/PKA/Tiam1/Rac1 Pathway. (2013)
  • Author(s): Kobayashi K, Tsubosaka Y, Hori M, Narumiya S, Ozaki H, Murata T.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 33 Pages: 565-571
  • Peer Reviewed
• [Journal Article] Bile Acid Receptor TGR5 Agonism Induces NO Production and Reduces Monocyte Adhesion in Vascular Endothelial Cells. (2013)
  • Author(s): Kida T, Tsubosaka Y, Hori M, Ozaki H, Murata T.
  • Journal Title: Arterioscler Thromb Vasc Biol. Volume: 33 Pages: 1663-9
  • Peer Reviewed
• [Journal Article] UDP promotes intestinal epithelial migration via the P2Y6 receptor. (2013)
  • Author(s): Nakamura T, Murata T, Hori M, Ozaki H.
  • Journal Title: British Journal of Pharmacology Volume: 170 Pages: 883-92
  • Peer Reviewed
• [Journal Article] eNOS derived nitric oxide regulates endothelial barrier function via VE cadherin and Rho GTPases. (2013)
  • Author(s): DiLorenzo A, Lin M, Murata T, Landskroner-Eiger S, Schleicher M, Kothiya M, Iwakiri Y, Yu J, Huang P, Sessa WC.
  • Journal Title: Journal of Cell Science. Volume: 126 Pages: 5541-52
  • Peer Reviewed
• [Journal Article] プロスタグランジンD2産生制御による障害組織再生方法の確立 (2013)
  • Author(s): 村田幸久
  • Journal Title: 循環医学研究年報 Volume: 第５集 Pages: 42-43
• [Journal Article] γ-Oryzanol reduces adhesion molecule expression in vascular endothelial cells via suppression of nuclear factor-κB activation (2012)
  • Author(s): Sakai S, Murata T, Tsubosaka Y, Ushio H, Hori M, Ozaki H
  • Journal Title: J Agric Food Chem Volume: 4;60(13) Issue: 13 Pages: 3367-3372
  • DOI: 10.1021/jf2043407
  • Peer Reviewed
• [Journal Article] EP2 and EP4 receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals (2012)
  • Author(s): Tajima T, Murata T, Aritake K, Urade U, Matsuoka T, Narumiya S, Ozaki H, Hori M
  • Journal Title: Am J Physiol Volume: 302(5) Issue: 5 Pages: G524-G534
  • DOI: 10.1152/ajpgi.00264.2011
  • Peer Reviewed
• [Journal Article] Prostaglandin E2 promotes wound-induced migration of intestinal subepithelial myofibroblasts via EP2, EP3, and EP4 prostanoid receptor activation (2012)
  • Author(s): Iwanaga K, Okada M, Murata T, Hori M, Ozaki H
  • Journal Title: J Pharmacol Exp Ther Volume: 340(3) Issue: 3 Pages: 604-611
  • DOI: 10.1124/jpet.111.189845
  • Peer Reviewed
• [Journal Article] 動脈硬化から組織を守る (2012)
  • Author(s): 村田幸久
  • Journal Title: 内藤財団時報 Volume: 90 Pages: 56-56
• [Journal Article] Prostagladin D2 is a mast cell-derived antiangiogenic factor in lung carcinoma. (2011)
  • Author(s): Murata T, Aritake K, Matsumoto S, Kamauchi S, Nakagawa T, Hori M, Momotani E, Urade Y, Ozaki H
  • Journal Title: Proc Natl Acad Sci USA Volume: 108(49) Issue: 49 Pages: 19802-19807
  • DOI: 10.1073/pnas.1110011108
  • Peer Reviewed
• [Journal Article] Effect of N-(p-coumaroyl)serotonin and N-feruloylserotonin, major anti-atherogenic polyphenols in safflower seed, on vasodilation, proliferation and migration of vascular smooth muscle cells (2011)
  • Author(s): Takimoto T, Suzuki K, Arisaka H, Murata T, Ozaki H, Koyama N
  • Journal Title: Mol Nutr Food Res. Volume: 55(10) Issue: 10 Pages: 1561-1571
  • DOI: 10.1002/mnfr.201000545
  • Peer Reviewed
• [Journal Article] Relaxant effect of prostaglandin D(2)--receptor DP agonist on liver myofibroblast contraction (2011)
  • Author(s): Maruyama T, Ayabe S, Murata T, Hori M, Ozaki H
  • Journal Title: J Pharmacol Sci. Volume: 116(2) Pages: 197-203
  • Peer Reviewed
• [Journal Article] Prostaglandin E_2-prostanoid EP_3 signal induces vascular contraction via nPKC and ROCK activation in rat mesenteric artery. (2011)
  • Author(s): Kobayashi K, Murata T, Hori M, Ozaki H
  • Journal Title: Eur J Pharmacol Volume: 660 Issue: 2-3 Pages: 375-380
  • DOI: 10.1016/j.ejphar.2011.03.032
  • Peer Reviewed
• [Journal Article] Increased contractility of hepatic stellate cells in cirrhosis is mediated by enhanced Ca2+-dependent and Ca2+-sensitization pathways (2011)
  • Author(s): Iizuka M, Murata T, Hori M, Ozaki H
  • Journal Title: Am J Physiol Gastrointest Liver Physiol Volume: 300(6) Issue: 6 Pages: G1010-G1021
  • DOI: 10.1152/ajpgi.00350.2010
  • Peer Reviewed
• [Journal Article] ATP induces contraction mediated by the P2Y2 receptor in rat intestinal subepithelial myofibroblasts (2011)
  • Author(s): Nakamura T, Iwanaga K, Murata T, Hori M, Ozaki H
  • Journal Title: Eur J Pharmacol Volume: 25;657 Issue: 1-3 Pages: 152-158
  • DOI: 10.1016/j.ejphar.2011.01.047
  • Peer Reviewed
• [Journal Article] Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery (2011)
  • Author(s): Kida T, Chuma H, Murata T, Yamawaki H, Matsumoto S, Hori M, Ozaki H
  • Journal Title: Atherosclerosis Volume: 214 Issue: 2 Pages: 288-294
  • DOI: 10.1016/j.atherosclerosis.2010.11.001
  • Peer Reviewed
• [Journal Article] Neuronal stimulation with 5-hydroxytryptamine 4 receptor induces anti-inflammatory actions via 7nACh receptors on muscularis macrophages associated with postoperative ileus (2011)
  • Author(s): Tsuchida Y, Hatao F, Fujisawa M, Murata T, Kaminishi M, Seto Y, Hori M, Ozaki H
  • Journal Title: Gut Volume: 60 Issue: 5 Pages: 638-647
  • DOI: 10.1136/gut.2010.227546
  • Peer Reviewed
• [Journal Article] Relaxant Effect of Prostaglandin D2-Receptor DP Agonist on Liver Myofibroblast Contraction (2011)
  • Author(s): Tomoharu Maruyama, Shinya Ayabe (equal contribution)
  • Journal Title: Journal of Pharmacological Sciences Volume: 116 Issue: 2 Pages: 197-203
  • DOI: 10.1254/jphs.10325FP
  • NAID: 10029894739
  • ISSN: 1347-8613, 1347-8648
  • Peer Reviewed
• [Journal Article] iNOS expression in vascular resident macrophages contributes to circulatory dysfunction of splanchnic vascular smooth muscle contractions in portal hypertension rats (2010)
  • Author(s): Kajita M, Murata T, Horiguchi K, Hori M and Ozaki H
  • Journal Title: Am J Physiol(Heart Circ Physiol) Volume: 300 Issue: 3 Pages: H1021-H1031
  • DOI: 10.1152/ajpheart.00563.2009
  • Peer Reviewed
• [Presentation] PGD2による血管透過性・血管新生制御機構とその病態治療への応用 (2011)
  • Author(s): 村田幸久
  • Organizer: 第151回日本獣医学会学術集会
  • Place of Presentation: 東京農工大学
  • Year and Date: 2011-03-31
• [Presentation] プロスタグランジンD2受容体刺激はEpac/Racの活性化を介して内皮バリア機能を亢進する (2011)
  • Author(s): 小林幸司、村田幸久、堀正敏、尾崎博
  • Organizer: 第151回日本獣医学会学術集会
  • Place of Presentation: 東京農工大学
  • Year and Date: 2011-03-31
• [Presentation] Stimulation of Prostaglandin D2 receptor DP promotes endothelial barrier function via Epac/Rac activation (2011)
  • Author(s): 小林幸司、村田幸久、堀正敏、尾崎博
  • Organizer: 第84回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2011-03-23
• [Presentation] Mast cell-derived PGD2 inhibits neoangiogenesis in lung carcinoma (2011)
  • Author(s): Murata T, Aritake K, Matsumoto S, Nakagawa T, Momotani E, Hori M, Urade Y, Ozaki H
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Four Points Sheraton, Ventura CA, USA
  • Year and Date: 2011-02-23
• [Presentation] PGD2 is a mast cell-derived anti-angiogenic factor in lung carcinoma (2010)
  • Author(s): Takahisa Murata
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-22
• [Presentation] 肝臓筋線維芽細胞におけるプロスタグランジンD2受容体作動薬の収縮抑制機構 (2010)
  • Author(s): 綾部信哉、丸山智晴、村田幸久、堀正敏、尾崎博
  • Organizer: 第150回日本獣医学会学術集会
  • Place of Presentation: 帯広畜産大学
  • Year and Date: 2010-09-16
• [Presentation] Mast cell-derived PGD2 is a novel anti-angiogenic factor in lung careinoma (2010)
  • Author(s): T.Murata, K.Aritake, T, Nakagawa, M.Hori, Y.Urade, H.Ozaki
  • Organizer: 第14回国際免疫学会議
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2010-08-26
• [Presentation] Bile Acid Receptor TGR5 Agonism Represents Anti-inflammatory Effects via Stimulating Nitric Oxide Production in Vascular Endothelial Cells
  • Author(s): Taiki Kida, Yoshiki Tsubosaka, Masatoshi Hori, Hiroshi Ozaki, and Takahisa Murata.
  • Organizer: ATVB2012
  • Place of Presentation: Chicago USA
• [Presentation] Prostaglandin D2-DP signal promotes endothelial barrier function via cAMP/PKA/Rac1 pathway
  • Author(s): Koji Kobayashi, Yoshiki Tsubosaka, Masatoshi Hori, Hiroshi Ozaki, Takahisa Murata
  • Organizer: Internatioanl Vascular Biology Meeting
  • Place of Presentation: Weisbaden Germany
• [Presentation] 胆汁酸受容体TGR5の刺激は血管内皮細胞のNO産生量を増加し、単球の接着を抑制する
  • Author(s): 貴田大樹 壷阪義記 村田幸久 堀正敏 尾崎博
  • Organizer: 第154回日本獣医学会
  • Place of Presentation: 岩手大学
• [Presentation] ProstaglandinE2による血管透過性制御機構の解明
  • Author(s): 大森啓介 貴田大樹 村田幸久 堀正敏 尾崎博
  • Organizer: 第154回日本獣医学会
  • Place of Presentation: 岩手大学
• [Presentation] SDF-1aはCXCR4/PI3K/Rac1経路を介して内皮細胞の透過性を抑制する
  • Author(s): 小林幸二 佐藤可奈子 貴田大樹 村田幸久 堀正敏 尾崎博
  • Organizer: 第22回 日本循環薬理学会
  • Place of Presentation: 富山国際会議場
• [Presentation] Stromal cell derived factor-1a-CXCR4 axis promotes endothelial cell barrier integrity via PI3K and Rac1 activation
  • Author(s): Koji Kobayashi, Kanako Sato, Taiki Kida, Masatoshi Hori, Hiroshi Ozaki, Takahisa Murata
  • Organizer: 第20回日本血管生物医学会
  • Place of Presentation: 徳島あわぎんホール
• [Presentation] Role of PGE2 in regulating vascular permeability
  • Author(s): Keisuke Omori, Taiki Kida, Masatoshi Hori, Hiroshi Ozaki, Takahisa Murata
  • Organizer: 第20回日本血管生物医学会
  • Place of Presentation: 徳島あわぎんホール
• [Presentation] SDF-1α Promotes Endothelial Cell Barrier Integrity via CXCR4 stimulation
  • Author(s): Kanako Sato, Koji Kobayashi, Taiki Kida, Masatoshi Hori, Hiroshi Ozaki, Takahisa Murata
  • Organizer: Gordon Research Conferences
  • Place of Presentation: Four Points Sheraton, Ventura CA, USA
• [Presentation] プロスタグランジンE2による血管収縮の増強と抑制
  • Author(s): 澤田慧、貴田大樹、小林幸司、村田幸久、堀正敏、尾崎博
  • Organizer: 第155回日本獣医学会
  • Place of Presentation: 東京大学
• [Presentation] Bile Acid Receptor TGR5 Agonism Enhances Vascular Endothelial Barrier Function
  • Author(s): Taiki Kida, Takahisa Murata, .Masatoshi Hori, Hiroshi Ozaki.
  • Organizer: 第86回日本薬理学会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Mast cell-derived prostaglandin D2 inhibits colitis-associated carcinogenesis through
  • Author(s): Koichi Iwanaga, Takahisa Murata, Masatoshi Hori, Kosuke Aritake, Yoshihiro Urade, Hiroshi Ozaki
  • Organizer: 第86回日本薬理学会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Mast cell derived prostaglandin D2 suppresses intestinal allergic inflammation
  • Author(s): Nakamura Tatsuro1, Murata Takahisa1, Matsumoto Shigeko1, Aritake Kosuke2, Masatoshi Hori1, Yoshihiro Urade2, Hiroshi Ozaki1.
  • Organizer: 第86回日本薬理学会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Role of PGE2 in regulating vascular permeability
  • Author(s): Keisuke Omori, Taiki Kida, Takahisa Murata, .Masatoshi Hori, Hiroshi Ozaki.
  • Organizer: 第86回日本薬理学会
  • Place of Presentation: 福岡国際会議場
• [Presentation] Ameliorative action of 5-HT3 receptor antagonist, ondansetron, for post-operative ileus
  • Author(s): Toko Maehara, Tatsuro Nakamura, Takahisa Murata, Masatoshi Hori, Hiroshi Ozaki
  • Organizer: 第86回日本薬理学会
  • Place of Presentation: 福岡国際会議場
• [Presentation] 睡眠誘発物質は癌の増殖を抑制する
  • Author(s): 村田幸久
  • Organizer: 第５回レドックス・ライフイノベーション
  • Place of Presentation: 味の素川崎工場
  • Invited
• [Presentation] PGD2-CRTH2シグナルはアジュバント誘発性関節炎を抑制する
  • Author(s): 壷阪義記、平井博之、堀正敏、中村正孝、尾崎博、村田幸久
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] ヒスタミンによる血管透過性制御機構の解明
  • Author(s): 芦名功平, 壷阪義記, 大森啓介, 堀正敏, 尾崎博, 村田幸久
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] 5-HT3R阻害剤は腹腔内マクロファージに作用し術後イレウスの炎症を軽減する
  • Author(s): 前原都有子、村田幸久、堀正敏、尾崎博
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] 術後イレウスにおけるa7nAch受容体を介したマクロファージ選択的抗炎症作用
  • Author(s): 猪村優貴、村田幸久、堀正敏、尾崎博
  • Organizer: 第156回日本獣医学会
  • Place of Presentation: 岐阜大学
• [Presentation] The role of prostaglandin D2 receptor CRTH2 in adjuvant-induced arthritis
  • Author(s): Yoshiki Tsubosaka, Masatoshi Hori, Hiroshi Ozaki, and Takahisa Murata.
  • Organizer: 第13回東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学
• [Presentation] The mechanism of Histamine-induced vascular hyper-permeability
  • Author(s): Kohei Ashina, Yoshiki Tsubosaka, Masatoshi Hori, Hiroshi Ozaki, and Takahisa Murata.
  • Organizer: 第13回東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学
• [Presentation] Opposing role of PGE2-EPs signalings on vascular permeability
  • Author(s): Keisuke Omori, Taiki Kida, Masatoshi Hori, Hiroshi Ozaki, Takahisa Murata
  • Organizer: 第13回東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学
• [Presentation] Deficiency of prostaglandin D2 receptor CRTH2 deteriorates adjuvant-induced arthritis
  • Author(s): Yoshiki Tsubosaka, Hiroyuki Hirai, Masatoshi Hori, Masataka Nakamura, Hiroshi Ozaki, Takahisa Murata.
  • Organizer: International Conference of Immunology
  • Place of Presentation: Milan Italia
• [Presentation] Mast cell-derived prostaglandin D2 suppresses intestinal mastocytosis in food allergy
  • Author(s): Tatsuro Nakamura, Shigeko Matsumoto, Kosuke Aritake, Masatoshi Hori, Hiroshi Ozaki, Yoshihiro Urade, Takahisa Murata.
  • Organizer: International Conference of Immunology
  • Place of Presentation: Milan Italia
• [Presentation] Prostaglandin D2 Represents Contradicting Roles in Dermatitis
  • Author(s): Hana Sarashina, Yoshiki Tsubosaka, Kosuke Aritake, Takayuki Nakagawa, Masatoshi Hori, Hiroshi Ozaki, Yoshihiro Urade, Takahisa Murata.
  • Organizer: International Conference of Immunology
  • Place of Presentation: Milan Italia
• [Presentation] The mechanism of histamine-induced vascular hyper-permeability
  • Author(s): Kohei Ashina, Yoshiki Tsubosaka, Keisuke Omori, Masatoshi Hori, Hiroshi Ozaki, Takahisa Murata.
  • Organizer: 第21回血管生物医学会
  • Place of Presentation: 千里阪急ホテル
• [Presentation] Prostaglandin D2 attenuates colitis and colitis-associated colon cancer.
  • Author(s): Murata Takahisa
  • Organizer: 第72回日本癌学会
  • Place of Presentation: パシフィコ横浜
• [Presentation] he role of prostaglandin D2 receptor CRTH2 in adjuvant-induced arthritis
  • Author(s): Tsubosaka Y, Hirai H, Nakamura M, Murata T.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Mast cell-derived prostaglandin D2 suppresses intestinal mastocytosis in murine model of food allergy
  • Author(s): Nakamura T, Murata T.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Prostaglandin E2による血管透過性制御機構の解明
  • Author(s): 大森啓介、貴田大樹、堀正敏、尾崎博、村田幸久
  • Organizer: 循環薬理学会
  • Place of Presentation: 福岡大学メデイカルホール
• [Presentation] 炎症性疾患におけるプロスタグランジンD2の役割
  • Author(s): 村田幸久
  • Organizer: 東京脂質談話会
  • Place of Presentation: 東京大学
  • Invited
• [Presentation] 皮膚炎におけるPGD2の役割
  • Author(s): 更級葉菜、村田幸久、有竹浩介、堀正敏、裏出良博、尾崎博.
  • Organizer: 第152回日本獣医学会学術集会
  • Place of Presentation: 大阪府立大学
• [Presentation] The role of prostaglandin D2 in dermatitis
  • Author(s): Sarashina Hana, Murata Takahisa.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Anti-inflammatory role of prostaglandin D2 in acute lung inflammation
  • Author(s): Murata Takahisa.
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ
• [Presentation] Mast-cell derived PGD2 inhibits neoangiogenesis in lung carcinoma.
  • Author(s): Takahisa Murata, Kosuke Aritake, Eiishi Momotani, Masatoshi Hori, Yoshihiro Urade, Hiroshi Ozaki.
  • Organizer: 第19回日本血管生物医学会学術集会
  • Place of Presentation: 東京ステーションコンフェレンス
  • Invited
• [Presentation] 急性肺炎の発症におけるProstaglandin D2の役割
  • Author(s): 村田幸久、壷阪義記、有竹浩介、堀正敏、裏出良博、尾崎博.
  • Organizer: 第21回日本循環薬理学会
  • Place of Presentation: 岡山大学50周年記念館
• [Presentation] Prostaglandin D2 受容体の刺激はcAMP/PKA/Rac1 経路を介して内皮細胞の透過性を抑制する。
  • Author(s): 小林 幸司、村田 幸久、堀 正敏、尾崎 博.
  • Organizer: 第21回日本循環薬理学会
  • Place of Presentation: 岡山大学50周年記念館
• [Presentation] SDF-1alpha inhibits vascular endothelial permeability.
  • Author(s): 佐藤可奈子、小林幸司、貴田大樹、村田幸久、堀正敏、尾崎博.
  • Organizer: 第85回日本薬理学会学術集会
  • Place of Presentation: 京都国際会議場
• [Presentation] PGD2 has opposing roles in the development of dermatitis.
  • Author(s): 更級葉菜、壷阪義樹、村田幸久、有竹浩介、堀正敏、裏出良博、尾崎博.
  • Organizer: 第85回日本薬理学会学術集会
  • Place of Presentation: 京都国際会議場
• [Presentation] 骨髄間質細胞由来因子（SDF）-1αの血管内皮透過性に対する作用とその機構の解明.
  • Author(s): 佐藤可奈子、小林幸二、貴田大樹、村田幸久、堀正敏、尾崎博.
  • Organizer: 第153回日本獣医学会学術集会
  • Place of Presentation: 大宮ソニックシティ
• [Presentation] Prostaglandin D 2 による血管新生制御機構とその病態治療への応用.
  • Author(s): 村田幸久
  • Organizer: 第153回日本獣医学会学術集会
  • Place of Presentation: 大宮ソニックシティ
  • Invited
• [Presentation] The Role of Prostaglandin D2 in Dermatitis.
  • Author(s): Hana Sarashina, Takahisa Murata.
  • Organizer: Keystone symposium
  • Place of Presentation: Snowbird, Utah, USA
• [Book] 年報 (2013)
  • Author(s): プロスタグランジンD2産生制御による障害組織再生方法の確立
  • Total Pages: 2
  • Publisher: 循環医学研究
• [Book] 年報 (2013)
  • Author(s): 食物アレルギー治療方法と病態マーカーの探索
  • Total Pages: 3
  • Publisher: 持田記念財団年報
• [Book] 年報 (2013)
  • Author(s): 食物アレルギーにおけるPGD2の役割の解明と治療への応用
  • Total Pages: 3
  • Publisher: 横浜総合医学振興財団
• [Remarks]
  • URL: http://www.vm.a.u-tokyo.ac.jp/houshasen/
• [Remarks] 東京大学大学院 獣医学専攻 獣医薬理学研究室
  • URL: http://www.vm.a.u-tokyo.ac.jp/labo/04.html
• [Remarks] 東京大学大学院農学生命科学研究科 教員プロフィールデータベース
  • URL: http://libcds1.lib.a.u-tokyo.ac.jp/infolib/meta_pub/CsvSearch.cgi
• [Remarks]
  • URL: http://www.vm.a.u-tokyo.ac.jp/yakuri/
• [Remarks]
  • URL: http://jglobal.jst.go.jp/public/20090422/200901096873654568
• [Remarks]
  • URL: http://researchmap.jp/read0123284/
• [Patent(Industrial Property Rights)] 血管新生促進剤 (2010)
  • Inventor(s): 村田 幸久, 裏出 良博, 有竹 浩介
  • Industrial Property Rights Holder: 東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2010-10-27
  • Overseas
• [Patent(Industrial Property Rights)] 血管新生促進在 (2010)
  • Inventor(s): 村田幸久、裏出良博、有竹浩介
  • Industrial Property Rights Holder: 東京大学
  • Filing Date: 2010-10-27
  • Overseas