Investigation of the pathophysiological role of an anti-inflammatory mediator prostaglandin D2.
Project/Area Number |
22688024
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Basic veterinary science/Basic zootechnical science
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Research Institution | The University of Tokyo |
Principal Investigator |
MURATA Takahisa 東京大学, 農学生命科学研究科, 准教授 (40422365)
|
Project Period (FY) |
2010-04-01 – 2013-03-31
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥26,910,000 (Direct Cost: ¥20,700,000、Indirect Cost: ¥6,210,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
|
Keywords | 薬理 / 炎症 / 病態 / 組織再生 / 薬理学 / 獣医学 / 癌 / 肥満細胞 / プロスタグランジン / 血管新生 |
Research Abstract |
We here investigated the pathophysiological role of an anti-inflammatory mediator prostaglandin D2. We found that 1) integral membrane protein Caveolin-1 modulates prostaglandin synthase activity, 2) urinary metabolite of prostaglandin D2 might be biomarker of various inflammatory diseases, 3) prostaglandin D2 signal enhancement inhibit the progressions of inflammatory diseases, 4) inhibition of prostaglandin D2 synthase leads vascular and tissue regenerations. These observations provide new insights for future therapy against inflammatory diseases and tissue re-generation.
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Report
(4 results)
Research Products
(96 results)
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[Journal Article] Opposing immunomodulatory roles of prostaglandin D2 during theprogression of skin inflammation.2014
Author(s)
Hana Sarashina, Yoshiki Tsubosaka, Keisuke Omori, Kosuke Aritake, Takayuki Nakagawa, Masatoshi Hori, Hiroyuki Hirai, Masataka Nakamura, Shuh Narumiya, Yoshihiro Urade, Hiroshi Ozaki and Takahisa Murata
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Journal Title
The Journal of Immunology
Volume: 192(1)
Issue: 1
Pages: 459-65
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] PDGF and TGF-beta promote tenascin-C expression in subepithelial myofibroblasts and contribute to intestinal mucosal protection in mice.2014
Author(s)
Islam MS, Kusakabe M, Horiguchi K, Iino S, Nakamura T, Iwanaga K, Hashimoto H, Matsumoto S, Murata T, Hori M, Ozaki H.
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Journal Title
British Journal of Pharmacology
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Opposing immunomodulatory roles of prostaglandin D2 during the progression of skin inflammation.2014
Author(s)
Sarashina H, Tsubosaka Y, Omori K, Aritake K, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H, Murata T.
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Journal Title
J Immunology
Volume: 192
Pages: 459-65
Related Report
Peer Reviewed
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[Journal Article] Dynamin-2 regulation of integrin endocytosis, but not VEGF signaling, is critical for developmental angiogenesis.2014
Author(s)
Lee M, Skoura A, Park EJ, Landskroner-Eiger S, Jozsef L, Luciano A, Murata T, Pasula S, Dong Y, Bouaouina M, Calderwood D, Ferguson S, DeCamilli P, Sessa WC.
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Journal Title
Development
Volume: 141
Pages: 1465-72
Related Report
Peer Reviewed
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[Journal Article] Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement2013
Author(s)
Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H
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Journal Title
Proc Natl Acad Sci U S A
Volume: 110(13)
Issue: 13
Pages: 5205-5210
DOI
Related Report
Peer Reviewed
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[Journal Article] Anti-inflammatory role of PGD2 in acute lung inflammation and therapeutic application of its signal enhancement.2013
Author(s)
Murata T, Aritake K, Tsubosaka Y, Maruyama T, Nakagawa T, Hori M, Hirai H, Nakamura M, Narumiya S, Urade Y, Ozaki H.
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Journal Title
Proceedings of the National Academy of Sciences of the United States of America.
Volume: 110
Pages: 5205-10
Related Report
Peer Reviewed
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[Book] 年報2013
Author(s)
食物アレルギー治療方法と病態マーカーの探索
Total Pages
3
Publisher
持田記念財団年報
Related Report
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