• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Pathophysiological role of the blood-brain barrier hemichannels and molecular-targeted diagnosis and therapy

Research Project

Project/Area Number 22689005
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Medical pharmacy
Research InstitutionTohoku University (2011-2013)
University of Toyama (2010)

Principal Investigator

TACHIKAWA MASANORI  東北大学, 薬学研究科(研究院), 准教授 (00401810)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2010: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywordsヘミチャネル / 脳毛細血管内皮細胞 / パネキシン / コネキシン / 輸送 / 血液脳関門 / 病態 / 阻害 / トランスポーター
Research Abstract

The present findings have established the new concept that specific subtypes of hemichannels, i.e., pannexin 1 and connexin 43, at the human blood-brain barrier (BBB) make a significant contribution to the dysfunction of the BBB transport system under acute ischemic conditions. This could raise the potential of the BBB hemichannels as a therapeutic target for brain ischemic damage exaggeration.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (73 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (29 results) (of which Peer Reviewed: 24 results) Presentation (38 results) (of which Invited: 5 results) Book (6 results)

  • [Journal Article] Quantitative targeted proteomics for understanding the blood-brain barrier : towards pharmacoproteomics2014

    • Author(s)
      Ohtsuki S, Hirayama M, Ito S, Uchida Y, Tachikawa M, Terasaki T
    • Journal Title

      Expert Rev Proteomics

      Volume: (in press) Issue: 3 Pages: 303-313

    • DOI

      10.1586/14789450.2014.893830

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A study protocol for quantitative targeted absolute proteomics (QTAP) by LC-MS/MS: application for inter-strain differences in protein expression levels of transporters, receptors, claudin-5, and marker proteins at the blood-brain barrier in ddY, FVB, and C57BL/6J mice2013

    • Author(s)
      Uchida Y, Tachikawa M, Obuchi W, Hoshi Y, Tomioka Y, Ohtsuki S, Terasaki T
    • Journal Title

      Fluids Barriers CNS

      Volume: 10(1) Pages: 21-21

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative atlas of blood-brain barrier transporters, receptors and tight junction proteins in rats and common marmoset2013

    • Author(s)
      Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T
    • Journal Title

      J Pharm Sci

      Volume: 102 Pages: 3343-55

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Targeted Absolute Proteomic Analysis of Transporters, Receptors and Junction Proteins for Validation of Human Cerebral Microvascular Endothelial Cell Line hCMEC/D3 as a Human Blood-Brain Barrier Model2013

    • Author(s)
      Ohtsuki S, Ikeda C, Uchida Y, Sakamoto Y, Miller F, Glacial F, Decleves X, Scherrmann JM, Couraud PO, Kubo Y, Tachikawa M, Terasaki T
    • Journal Title

      Mol Pharm

      Volume: 10 Pages: 289-296

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血液脳関門トランスポートソームの定量的絶対発現プロファイル : 動物種間, 系統間, 野生型-遺伝子欠損マウス間の相違性と類似性2013

    • Author(s)
      内田康雄, 立川正憲, 星裕太朗, 寺崎哲也
    • Journal Title

      脳21

      Volume: 16 Pages: 46-52

    • Related Report
      2013 Final Research Report
  • [Journal Article] 動的インターフェースとしての脳関門輸送システムと脳関門生理学・創薬研究2013

    • Author(s)
      立川正憲, 内田康雄, 寺崎哲也
    • Journal Title

      BRAIN and NERVE

      Volume: 65 Pages: 121-137

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
  • [Journal Article] 標的絶対定量プロテオミクスが拓くヒト血液脳関門輸送機能研究2013

    • Author(s)
      立川正憲, 内田康雄, 寺崎哲也
    • Journal Title

      Drug Delivery System

      Volume: 28 Pages: 270-278

    • NAID

      130003384377

    • Related Report
      2013 Final Research Report
  • [Journal Article] Quantitative atlas of blood-brain barrier transporters, receptors and tight junction proteins in rats and common marmoset.2013

    • Author(s)
      Hoshi Y, Uchida Y, Tachikawa M, Inoue T, Ohtsuki S, Terasaki T
    • Journal Title

      J Pharm Sci

      Volume: 102 Issue: 9 Pages: 3343-3355

    • DOI

      10.1002/jps.23575

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 血液脳関門トランスポートソームの定量的絶対発現プロファイル:動物種間,系統間,野生型-遺伝子欠損マウス間の相違性と類似性2013

    • Author(s)
      内田康雄、立川正憲、星裕太朗、寺崎哲也
    • Journal Title

      脳21

      Volume: 16 Pages: 46-52

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E_2 produced in the brain2012

    • Author(s)
      Tachikawa M, Ozeki G, Higuchi T, Akanuma S, Tsuji K, Hosoya K
    • Journal Title

      J Neurochem

      Volume: 12 Pages: 750-760

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid : role of the blood-cerebrospinal barrier transporters2012

    • Author(s)
      Tachikawa M, Tsuji K, Yokoyama R, Higuchi T, Ozeki G, Yashiki A, Akanuma S, Hayashi K, Nishiura A, Hosoya K
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 343 Pages: 608-616

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of the blood-cerebrospinal fluid barrier transporter as a cerebral clearance system for prostaglandin E2 produced in the brain.2012

    • Author(s)
      Tachikawa M
    • Journal Title

      J Neurochem

      Volume: 123 Issue: 5 Pages: 750-760

    • DOI

      10.1111/jnc.12018

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A clearance system for prostaglandin D2, a sleep-promoting factor, in the cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters.2012

    • Author(s)
      Tachikawa M
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 343 Issue: 3 Pages: 608-616

    • DOI

      10.1124/jpet.112.197012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative targeted absolute proteomic analysis of transporters, receptors and junction proteins for validation of human cerebral microvascular endothelial cell line hCMEC/D3 as a human blood-brain barrier model2012

    • Author(s)
      Ohtsuki S
    • Journal Title

      Mol Pharm

      Volume: 10 Issue: 1 Pages: 289

    • DOI

      10.1021/mp3004308

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Strategies for therapy of retinal diseases using systemic drug delivery : relevance of transporters at the blood-retinal barrier2011

    • Author(s)
      Hosoya K, Tomi M, Tachikawa M
    • Journal Title

      Expert Opin Drug Deliv

      Volume: 8 Pages: 1571-1587

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of organic anion/cation transporters at the blood-brain and blood-cerebrospinal fluid barriers involving uremic toxins2011

    • Author(s)
      Hosoya K, Tachikawa M
    • Journal Title

      Clin Exp Nephrol

      Volume: 15 Pages: 478-485

    • NAID

      10029571602

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal transfer of nicotinate by H^+-monocarboxylate transporter at the inner blood-retinal barrier2011

    • Author(s)
      Tachikawa M, Murakami K, Martin P, Hosoya K, Ganapathy V
    • Journal Title

      Microvas Res

      Volume: 82 Pages: 385-390

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Amyloid-β peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier2011

    • Author(s)
      Fujiyoshi M, Tachikawa M, Ohtsuki S, Ito S, Uchida Y, Akanuma S, Kamiie J, Hashimoto T, Hosoya K, Iwatsubo T, Terasaki T
    • Journal Title

      J Neurochem

      Volume: 118 Pages: 407-415

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Inner Blood-Retinal Barrier Mediates L-Isomer-Predominant Transport of Serine2011

    • Author(s)
      Tachikawa M, Okamoto M, Hirose S, Yoneyama D, Akanuma S, Terasaki T, Hosoya K
    • Journal Title

      J Pharm Sci

      Volume: 100 Pages: 3892-903

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 定量的絶対標的プロテオミクスに基づくヒト血液脳関門におけるトランスポーターの発現と生理機能2011

    • Author(s)
      立川正憲, 内田康雄, 大槻純男, 寺崎哲也
    • Journal Title

      脳21

      Volume: 14 Pages: 42-48

    • Related Report
      2013 Final Research Report
  • [Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders2011

    • Author(s)
      Tachikawa M, Hosoya K
    • Journal Title

      Fluids Barriers CNS

      Volume: 8 Pages: 13-13

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hypertonicity Enhances GABA Uptake by Cultured Rat Retinal Capillary Endothelial Cells2011

    • Author(s)
      Yahara T, Tachikawa M, Akanuma S, Hosoya K
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 25 Pages: 611-615

    • NAID

      10027744026

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The inner blood-retinal barrier mediates L-isomer-predominant transport of serine2011

    • Author(s)
      Tachikawa M., Okamoto M., et al
    • Journal Title

      J Pharm Sci

      Volume: 100 Issue: 9 Pages: 3892-3903

    • DOI

      10.1002/jps.22626

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transport systems of serine at the brain barriers and in brain parenchymal cells2011

    • Author(s)
      Kasai Y., Tachikawa M., Hirose S., Akanuma S., Hosoya K.
    • Journal Title

      J. Neurochem

      Volume: 118 Issue: 2 Pages: 304-13

    • DOI

      10.1111/j.1471-4159.2011.07313.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal transfer of nicotinate by H^+-monocarboxylate transporter at the inner blood-retinal barrier2011

    • Author(s)
      Tachikawa M., Murakami K., et al
    • Journal Title

      Microvasc Res

      Volume: 82 Issue: 3 Pages: 385-390

    • DOI

      10.1016/j.mvr.2011.06.009

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier : relevance to neural disorders.2011

    • Author(s)
      Tachikawa M.
    • Journal Title

      Fluids Barriers CNS

      Volume: 8 Pages: 13-13

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lipophilicity and transporter influence on blood-retinal barrier permeability : a comparison with blood-brain barrier permeability2010

    • Author(s)
      Hosoya K, Yamamoto A, Akanuma S, Tachikawa M
    • Journal Title

      Pharm Res

      Volume: 27 Pages: 2715-2724

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lipophilicity and transporter influence on blood-retinal barrier permeability : a comparison with blood-brain barrier permeability.2010

    • Author(s)
      Hosoya K.
    • Journal Title

      Pharm Res

      Volume: 27 Pages: 2715-2724

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypertonicity enhances GABA uptake by cultured rat retinal capillary endothelial cell.2010

    • Author(s)
      Yahara T.
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 25 Pages: 611-615

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 血液脳関門ヘミチャネルの病態生理学的役割と中枢疾患治療標的としての可能性2014

    • Author(s)
      立川正憲, 金子洋介, 赤荻諒, 内田康雄, 大槻純男, 寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本
    • Year and Date
      2014-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Pharmacological impact of the brain barrier prostaglandin transport2014

    • Author(s)
      Tachikawa M
    • Organizer
      20th Annual Blood-Brain Barrier Consortium Meeting
    • Place of Presentation
      Sunriver, USA
    • Year and Date
      2014-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 血液脳関門輸送機能変動因子としてのヘミチャネル2013

    • Author(s)
      立川正憲
    • Organizer
      第35回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-11-22
    • Related Report
      2013 Final Research Report
  • [Presentation] Pathophysiological impact and characteristics of pannexin and connexin hemichannels-mediated transport at the blood-brain barrier2013

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      日本薬物動態学会第28年会
    • Place of Presentation
      東京
    • Year and Date
      2013-10-11
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of pannexin and connexin hemichannels in the pathological human blood-brain barrier transport2013

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      10th International ISSX Meeting
    • Place of Presentation
      Toronto, Canada
    • Year and Date
      2013-09-30
    • Related Report
      2013 Final Research Report
  • [Presentation] Application of quantitative targeted proteomics to the human blood-brain barrier hemichannel research2013

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      International Gap Junction Conference 2013
    • Place of Presentation
      Charleston, USA
    • Year and Date
      2013-07-16
    • Related Report
      2013 Final Research Report
  • [Presentation] 標的プロテオミクスに基づくヘミチャネルファミリーの生体内定量的分布と機能2013

    • Author(s)
      立川正憲, 金子洋介, 内田康雄, 大槻純男, 寺崎哲也
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋
    • Year and Date
      2013-05-25
    • Related Report
      2013 Final Research Report
  • [Presentation] 標的プロテオミクスに基づく組織細胞特異的ヘミチャネル発現プロファイルの構築2013

    • Author(s)
      立川正憲, 金子洋介, 内田康雄, 大槻純男, 寺崎哲也
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Year and Date
      2013-03-28
    • Related Report
      2013 Final Research Report
  • [Presentation] Impact of pannexin and connexin hemichannels on the human blood-brain barrier transport : An application of quantitative targeted proteomics2013

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      10th international conference on Cerebral Vascular Biology
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of pannexin and connexin hemichannels in the pathological human blood-brain barrier transport.2013

    • Author(s)
      Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
    • Organizer
      10th International ISSX Meeting
    • Place of Presentation
      Toronto, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] Impact of pannexin and connexin hemichannels on the human blood-brain barrier transport: An application of quantitative targeted proteomics2013

    • Author(s)
      Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
    • Organizer
      10th international conference on Cerebral Vascular Biology
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2013 Annual Research Report
  • [Presentation] Functional expression of pannexin an connexin hemichannels at the human blood-brain barrier2012

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Ohtsuki S, Couraud PO, Terasaki T
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Year and Date
      2012-11-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Profile of hemichannls mRNA expresson at the blood-brain and inner blood-retinal barriers in mice2012

    • Author(s)
      Akanuma S, Murakami K, Tachikawa M, Kubo Y, Hosoya K
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Year and Date
      2012-11-20
    • Related Report
      2013 Final Research Report
  • [Presentation] ヘミチャネルファミリーを標的とした定量プロテオミクス2012

    • Author(s)
      立川正憲, 金子洋介, 内田康雄, 寺崎哲也
    • Organizer
      日本薬学会東北支部大会
    • Place of Presentation
      青森
    • Year and Date
      2012-10-07
    • Related Report
      2013 Final Research Report
  • [Presentation] Pathophysiological impact of hemichannels on the blood-brain barrier transport2012

    • Author(s)
      Tachikawa M, Kaneko Y, Uchida Y, Couraud PO, Terasaki T
    • Organizer
      Fifteenth International Symposium Signal Transduction in the Blood-Brain Barriers
    • Place of Presentation
      Potsdam-Sanssouci, Germany
    • Year and Date
      2012-09-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Proteomics-based technology as a new path to toxicological evaluation2012

    • Author(s)
      Tachikawa M
    • Organizer
      2012 International Symposium on Green Toxicology & Technology : Prediction of Kidney Toxicity
    • Place of Presentation
      Seoul, South Korea
    • Year and Date
      2012-09-07
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳及び網膜毛細血管内皮細胞におけるヘミチャネル分子のmRNA 発現解析2012

    • Author(s)
      村上晃路, 立川正憲, 赤沼伸乙, 久保義行, 細谷健一
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 脳及び網膜毛細血管皮細胞におけるヘミチャネル分子のmRNA発現解析2012

    • Author(s)
      村上晃路、立川正憲, 他
    • Organizer
      日本薬学会第132年会
    • Place of Presentation
      札幌
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Targeted proteomics for pannexin and connexin hemichannels in human brain capillary endothelial cells2012

    • Author(s)
      金子洋介、立川正憲, 他
    • Organizer
      BRI International Symposium 2012
    • Place of Presentation
      新潟
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional expression of pannexin and connexin hemichannels at the blood-brain barrier and inner blood-retinal barrier in rodents2012

    • Author(s)
      立川正憲、村上晃路, 他
    • Organizer
      BRI International Symposium 2012
    • Place of Presentation
      新潟
    • Year and Date
      2012-03-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] Targeted proteomics for pannexin and connexin hemichannels in human brain capillary endothelial cells2012

    • Author(s)
      金子洋介, 立川正憲, 寺崎哲也
    • Organizer
      第2回新潟大学脳研究所共同研究拠点国際シンポジウム
    • Place of Presentation
      新潟
    • Related Report
      2013 Final Research Report
  • [Presentation] Functional expression of pannexin and connexin hemichannels at the blood-brain barrier and inner blood-retinal barrier in rodents2012

    • Author(s)
      立川正憲, 村上晃路, 赤沼伸乙, 細谷健一
    • Organizer
      第2回新潟大学脳研究所共同研究拠点国際シンポジウム
    • Place of Presentation
      新潟
    • Related Report
      2013 Final Research Report
  • [Presentation] Pathophysiological impact of hemichannels on the blood-brain barrier transport.2012

    • Author(s)
      Tachikawa M
    • Organizer
      15th International Symposium Signal Transduction in the Blood-Brain Barriers
    • Place of Presentation
      Potsdam-Sanssouci, Germany
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] グアニジノ化合物のトランスポーターと脳関門輸送2011

    • Author(s)
      立川正憲
    • Organizer
      第32回グア ニジノ化合物研究会
    • Place of Presentation
      酒田
    • Year and Date
      2011-10-29
    • Related Report
      2013 Final Research Report
  • [Presentation] グアニジノ化合物のトランスポーターと脳関門輸送2011

    • Author(s)
      立川正憲
    • Organizer
      第32回グアニジノ化合物研究会
    • Place of Presentation
      酒田(招待講演)
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 「脳関門-神経-グリア」機能的ネットワークにおけるトランスポーターの役割2010

    • Author(s)
      立川正憲, 細谷健一
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山
    • Year and Date
      2010-11-30
    • Related Report
      2013 Final Research Report
  • [Presentation] 「脳関門-神経-グリア」機能的ネットワークにおけるトランスポーターの役割2010

    • Author(s)
      立川正憲
    • Organizer
      第32回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      富山国際会議場(富山市)
    • Year and Date
      2010-11-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 標的プロテオミクスに基づくヘミチャネルファミリーの生体内定量的分布と機能

    • Author(s)
      立川正憲、金子洋介、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬剤学会第28年会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pathophysiological impact and characteristics of pannexin and connexin hemichannels-mediated transport at the blood-brain barrier.

    • Author(s)
      Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
    • Organizer
      日本薬物動態学会第28年会
    • Place of Presentation
      東京都江戸川区
    • Related Report
      2013 Annual Research Report
  • [Presentation] 血液脳関門輸送機能変動因子としてのヘミチャネル

    • Author(s)
      立川正憲
    • Organizer
      第35回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      東京都文京区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 血液脳関門ヘミチャネルの病態生理学的役割と中枢疾患治療標的としての可能性

    • Author(s)
      立川正憲、金子洋介、赤荻諒、内田康雄、大槻純男、寺崎哲也
    • Organizer
      日本薬学会第134年会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Application of quantitative targeted proteomics to the human blood-brain barrier hemichannel research

    • Author(s)
      Tachikawa M., Kaneko Y., Uchida Y., Couraud P.O., Terasaki T.
    • Organizer
      International Gap Junction Conference 2013
    • Place of Presentation
      Charleston, South Carolina, United States
    • Related Report
      2013 Annual Research Report
  • [Presentation] Pharmacological impact of the brain barrier prostaglandin transport

    • Author(s)
      Tachikawa M.
    • Organizer
      20th Annual Blood-Brain Barrier Consortium Meeting
    • Place of Presentation
      Sunriver, Oregon, United States
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 標的プロテオミクスに基づく組織細胞特異的ヘミチャネル発現プロファイルの構築

    • Author(s)
      立川正憲
    • Organizer
      日本薬学会第133年会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] Proteomics-based technology as a new path to toxicological evaluation

    • Author(s)
      Tachikawa M
    • Organizer
      2012 International Symposium on Green Toxicology & Technology: Prediction of Kidney Toxicity
    • Place of Presentation
      Seoul, South Korea
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Functional expression of pannexin an connexin hemichannels at the human blood-brain barrier.

    • Author(s)
      Tachikawa M
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] Profile of hemichannls mRNA expresson at the blood-brain and inner blood-retinal barriers in mice.

    • Author(s)
      Akanuma S
    • Organizer
      日本薬物動態学会第27年会
    • Place of Presentation
      千葉
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヘミチャネルファミリーを標的とした定量プロテオミクス

    • Author(s)
      立川正憲
    • Organizer
      日本薬学会東北支部大会
    • Place of Presentation
      青森
    • Related Report
      2012 Annual Research Report
  • [Book] Recent progress in the blood-brain barrier and the blood-CSF barrier transport research : Pharmaceutical relevance of drug delivery to the brain. Drug Delivery to the Brain-Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)2014

    • Author(s)
      Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
    • Publisher
      Springer, New York
    • Related Report
      2013 Final Research Report
  • [Book] Blood-brain barrier (BBB) pharmacoproteomics : a new research field opened up by quantitative targeted absolute proteomics (QTAP). Drug Delivery to the Brain-Physiological Concepts, Methodologies and Approaches, Hammarlund-Udenaes M, de Lange E, and Thorne R (Ed)2014

    • Author(s)
      Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Publisher
      Springer, New York
    • Related Report
      2013 Final Research Report
  • [Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014

    • Author(s)
      Uchida Y, Tachikawa M, Ohtsuki S, Terasaki T
    • Total Pages
      731
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] Drug Delivery to the Brain ; Physiological Concepts, Methodologies and Approaches2014

    • Author(s)
      Tachikawa M, Uchida Y, Ohtsuki S, Terasaki T
    • Total Pages
      731
    • Publisher
      Springer
    • Related Report
      2013 Annual Research Report
  • [Book] Systemic route for retinal drug delivery : role of the blood-retinal barrier transporters. Drug Product Development for the Back of the Eye, Kompella U. B. and Edelhauser H. F. (Ed), American Association of Pharmaceutical Scientists2011

    • Author(s)
      Tachikawa M, Ganapathy V, Hosoya K
    • Publisher
      Press-Springer, New York
    • Related Report
      2013 Final Research Report
  • [Book] Systemic route for retinal drug delivery : role of the blood-retinal barrier, In Drug Product Development for the Back of the Eye2011

    • Author(s)
      Tachikawa M., Ganapathy V., Hosoya K.
    • Publisher
      Springer
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi