Research Project
Grant-in-Aid for Young Scientists (A)
In c-Src-induced transformation, we found that the lipid composition of rafts and the expression of lipid metabolism genes are changed. The addition of cholesterol to rafts efficiently suppressed c-Src-induced cell transformation. We also found that the miR-99a-mTOR/ FGFR3 pathway is crucial for controlling tumor growth and that c-Src. miR-542-3p. ILK. FAK circuit plays a pivotal role in controlling tumor progression. Our study provides insights into these novel signaling axes in the Src-related oncogenic pathway.
All 2012 2011 2010 Other
All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (22 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)
Oncogene 2012
Volume: 31(13) Issue: 13 Pages: 1623-35
10.1038/onc.2011.367
Biochem Biophys Res Commun
Volume: 417(4) Pages: 1151-7
J Biol Chem
Volume: 287(2) Issue: 2 Pages: 1588-99
10.1074/jbc.m111.315127
Volume: 417(4) Issue: 4 Pages: 1151-7
10.1016/j.bbrc.2011.12.082
Oncogene 2011
Volume: 30(32) Issue: 32 Pages: 3489-501
10.1038/onc.2011.63
J Cell Sci 2011
Volume: 124(Pt 10) Issue: 10 Pages: 1726-38
10.1242/jcs.080291
J Biol Chem 2011
Volume: 286(18) Issue: 18 Pages: 15698-706
10.1074/jbc.m110.195362
Mol Cancer Res
Volume: 9(1) Issue: 1 Pages: 103-14
10.1158/1541-7786.mcr-10-0340
Oncogene
Volume: (印刷中)
J Cell Sci
J Biol Chem.
Mol Cancer Res.
Volume: 9 Pages: 103-114
Genes Cells
Volume: 15(10) Issue: 10 Pages: 1051-1062
10.1111/j.1365-2443.2010.01439.x
Diabetes
Volume: 60(1) Issue: 1 Pages: 218-226
10.2337/db10-0021
Volume: 60 Pages: 218-226
Volume: 15 Pages: 1051-1062
http://www.biken.osaka-u.ac.jp/biken/oncogene/index.htm