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Analysis of age-related diseases with oxidative stress in mitochondrial ROS-inducible model mice

Research Project

Project/Area Number 22689012
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionTokai University

Principal Investigator

ISHII Takamasa  東海大学, 医学部, 講師 (20548680)

Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords酸化ストレス / ミトコンドリア / 習慣流産 / 不妊 / 神経変性疾患 / 学習記憶 / レドックスシグナル / マウス / 活性酸素 / 生活習慣病 / シグナル伝達 / 学習・記憶
Research Abstract

In this study, we focused on age-related diseases with oxidative stress. The age-dependent alterations of tissue functions caused by oxidative stress were analyzed in mitochondrial reactive oxygen species (ROS)-inducible model Tet-mev-1 mice. In the results, 1) low-birth-weight infants, 2) accelerated age-related corneal dysfunctions with dry eyes by lacrimal gland inflammations, 3) glial environmental defects in hippocampal regions with age, 4) recurrent abortions and maternal death, and 5) chronic hyperglycemia were confirmed as aging phenomena caused by mitochondrial oxidative stress. It was expecting that a means would be demonstrated to suppress the age-dependent homeostatic unbalanced alterations in individuals, when these molecular mechanisms would be clarified in this mouse model.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (72 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (52 results) (of which Invited: 11 results) Remarks (8 results)

  • [Journal Article] Genetically induced oxidative stress in mice causes thrombocytosis, splenomegaly and placental angiodysplasia that leads to recurrent abortion2014

    • Author(s)
      Takamasa Ishii, Masaki Miyazawa, Yumi Takanashi, Maya Tanigawa, Kayo Yasuda, Noboru Kawabe, Junji Mitsushita, Phil S. Hartman, Naoaki Ishii
    • Journal Title

      Redox Biology

      Volume: 2 Pages: 679-685

    • URL

      http://www.sciencedirect.com/science/article/pii/S2213231714000664

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Model animals for the study of oxidative stress from complexII. Biochimica et Bioohysica Acta (BBA) -2013

    • Author(s)
      Takamasa Ishii, Masaki Miyazawa, Hiromi Onouchi, Kayo Yasuda, Phil S. Hartman, Naoaki Ishii
    • Journal Title

      Bioenergetics

      Volume: 1827 Pages: 588-597

    • URL

      http://www.sciencedirect.com/science/article/pii/S0005272812010730

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Model animals for the study of oxidative stress from complex II2013

    • Author(s)
      Takamasa Ishii
    • Journal Title

      Biochem. Biophys. Acta.

      Volume: 1827 Issue: 5 Pages: 588-597

    • DOI

      10.1016/j.bbabio.2012.10.016

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Predicting longevity in C. elegans: fertility, mobility and gene expression.2013

    • Author(s)
      Cypser J.R., Wu D., Park S.K., Ishii T., Tedesco P.M., Mendenhall A.R., Johnson T.E.
    • Journal Title

      MECHANISMS OF AGEING AND DEVELOPMENT

      Volume: 134 Issue: 7-8 Pages: 291-297

    • DOI

      10.1016/j.mad.2013.02.003

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ミトコンドリア酸化ストレス発生mev-1モデルの解析2013

    • Author(s)
      石井恭正
    • Journal Title

      基礎老化研究

      Volume: 37 Pages: 13-20

    • NAID

      10031144410

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oxidative stress induced inflammation initiates functional decline of tear production2012

    • Author(s)
      Uchino Y, Kawakita T, Miyazawa M, Ishii T, Onouchi H, Yasuda K, Ogawa Y, Shimmura S, Ishii N, Tsubota K.
    • Journal Title

      PLoS ONE

      Volume: 7 Issue: 10 Pages: e45805-e45805

    • DOI

      10.1371/journal.pone.0045805

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new mouse model of dry eye disease: oxidative stress affects functional decline in the lacrimal gland.2012

    • Author(s)
      Yuichi Uchino
    • Journal Title

      Cornea

      Volume: 31 Issue: Supplement 1 Pages: S63-S67

    • DOI

      10.1097/ico.0b013e31826a5de1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial superoxide anion overproduction in Tet-mev-1 transgenic mice accelerates age-dependent corneal cell dysfunctions2012

    • Author(s)
      Onouchi H, Ishii T, Miyazawa M, Uchino Y, Yasuda K, Hartman PS, Kawai K, Tsubota K, Ishii N
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53 Issue: 9 Pages: 5780-5787

    • DOI

      10.1167/iovs.12-9573

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial superoxide anion (O_2^-) inducible "mev-1" animal models for aging research2011

    • Author(s)
      Takamasa Ishii, Masaki Miyazawa, Phil S. Hartman, Naoaki Ishii
    • Journal Title

      BMB Rep

      Volume: 44 Pages: 298-305

    • URL

      http://www.bmbreports.org/fulltext/bmbreports/view.php?vol=44&page=298

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation2011

    • Author(s)
      Takamasa Ishii, Masaki Miyazawa, Akira Onodera, Kayo Yasuda, Noboru Kawabe, Mika Kirinashizawa, Shinichi Yoshimura, Naoki Maruyama, Phil S. Hartman, Naoaki Ishii
    • Journal Title

      Mitochondrion

      Volume: 11 Pages: 155-165

    • URL

      http://www.sciencedirect.com/science/article/pii/S1567724910001613

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondria superoxide anion (O_2^-) inducible "mev-I" animal models for aging research2011

    • Author(s)
      Ishii T, Miyazawa M, Hartman PS, Ishii N
    • Journal Title

      BMB report

      Volume: 44 Issue: 5 Pages: 298-305

    • DOI

      10.5483/bmbrep.2011.44.5.298

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation.2011

    • Author(s)
      Takamasa Ishii, et al.
    • Journal Title

      Mitochondrion

      Volume: 11 Pages: 155-165

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mitochondrial reactive oxygen species exert age-dependent contradictory effects on hippocampus-dependent spatial memory2014

    • Author(s)
      Takamasa Ishii, Masaki Miyazawa, Kayo Yasuda, Phil S. Hartman, Naoaki Ishii
    • Organizer
      Aging - Pushing the Limits of Cellular Quality Control, Keystone Symposia on Molecular and Cellular Biology
    • Place of Presentation
      Colorado, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Effects of Mitochondrial ROS from Complex II on Age-related Impairments or Unbalanced Homeostatic Regulations2013

    • Author(s)
      Takamasa Ishii, et al
    • Organizer
      International Symposium on Mitochondria 2013, The Japanese Society of Mitochondrial Research and Medicine
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Invited
  • [Presentation] Mitochondrial ROS and Aging2013

    • Author(s)
      Takamasa Ishii, et al
    • Organizer
      The 20th IAGG World Congress of Gerontology and Geriatrics, IAGG 2013
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] MITOCHONDRIAL ROS AND AGING2013

    • Author(s)
      Takamasa Ishii, Phil S. Hartman, Naoaki Ishii
    • Organizer
      The 20th IAGG World Congress of Gerontology and Geriatrics, IAGG 2013
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ミトコンドリア酸化ストレスに惹起される脳内環境の加齢変化と記憶障害2013

    • Author(s)
      石井恭正、高梨由美、柳原倫太郎、浅利真司、安田佳代、石井直明
    • Organizer
      日本基礎老化学会第36回大会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミトコンドリア酸化ストレスと加齢性角膜障害2013

    • Author(s)
      石井恭正、尾内宏美、内野裕一、高梨由美、宮沢正樹、安田佳代、石井直明
    • Organizer
      第66回日本酸化ストレス学会学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2013 Annual Research Report
  • [Presentation] THE MECHANISM OF LONGEVITY WITH HORMESIS BY THE LOW DOSE X RAY-IRRADIATION IN C. ELEGANS2013

    • Author(s)
      Seitaro Hayashi, Kayo Yasuda, Takamasa Ishii, Naoaki Ishii
    • Organizer
      The 20th IAGG World Congress of Gerontology and Geriatrics, IAGG 2013
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Annual Research Report
  • [Presentation] Energy Metabolic Shift for Longevity with Hormesis by Low Dose X ray-irradiation in C. elegans2013

    • Author(s)
      Seitaro Hayashi, Kayo Yasuda, Takamasa Ishii, Naoaki Ishii
    • Organizer
      International Symposium on Mitochondria 2013, The Japanese Society of Mitochondrial Research and Medicine
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] ミトコンドリア由来活性酸素惹起モデルマウスを用いた酸化ストレスによる肝線維化促進機序の解明2013

    • Author(s)
      茂呂忠、中尾祥絵、住吉秀明、宮沢正樹、石井恭正、石井直明、稲垣豊
    • Organizer
      第45回日本結合組織学会学術大会、第60回マトリックス研究会大会合同学術大会
    • Place of Presentation
      和歌山
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mitochondrial oxidative stress exacerbates inflammation and subsequent fibrogenesis in high fat diet-induced murine hepatic steatosis2013

    • Author(s)
      Tadashi Moro, Sachie Nakao, Hideaki Sumiyoshi, Takamasa Ishii, Masaki Miyazawa, Naoaki Ishii, Yutaka Inagaki
    • Organizer
      17th International Symposium on Cells of the Hepatic Sinusoid, International Society for Hepatic Sinusoidal Research
    • Place of Presentation
      Osaka, Japan
    • Related Report
      2013 Annual Research Report
  • [Presentation] Direct contribution of mitochondrial oxidative stress to hepatic fibrogenesis2013

    • Author(s)
      Tadashi Moro, Sachie Nakao, Hideaki Sumiyoshi, Takamasa Ishii, Masaki Miyazawa, Naoaki Ishii, Yutaka Inagaki
    • Organizer
      The 64th Annual Meeting of the American Association for the Study of Liver Diseases
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Mitochondrial oxidative stress-inducible mev-1 models for aging research. Molecular and Cellular Biology of Aging2012

    • Author(s)
      Takamasa Ishii, et al
    • Organizer
      The 34th Japanese Society for Biomedical Gerontology Symposium and Micro-Nano Global COE
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      2012-10-16
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 活性酸素過剰発生マウスTet-mev-1におけるCoQ10投与効果2012

    • Author(s)
      浅利真司, 他
    • Organizer
      第9回日本コエンザイムQ協会研究会
    • Place of Presentation
      東京工科大学(東京都)
    • Year and Date
      2012-01-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of mitochondrial oxidative stress induced by the complex II SDHC V69E mutation on infertility and habitual abortion. Molecular Genetics of Aging2012

    • Author(s)
      Takamasa Ishii, et al
    • Organizer
      Cold Spring Harbor Meeting 2012
    • Place of Presentation
      New York, USA
    • Related Report
      2013 Final Research Report
  • [Presentation] Mitochondrial Superoxide-accelerated Age-dependent Corneal Cell Dysfunctions2012

    • Author(s)
      Takamasa Ishii, et al
    • Organizer
      The 2012 Spring Conference of the Korean Society for Gerontology and the 11th Korea-Japan Gerontologist Joint meeting
    • Place of Presentation
      Osong, Korea
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Abnormal Lymphocyte Accumulations in Tet-mev-1 (SDHC V69E) Conditional Transgenic Mice2012

    • Author(s)
      Shinji Asari
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(博多)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Mechanism of Longevity with Hormesis by the Low Dose X-irradiation in C. elegans2012

    • Author(s)
      Seitaro Hayashi
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場(博多)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミトコンドリア酸化ストレスと角膜疾患2012

    • Author(s)
      石井恭正
    • Organizer
      日本ミトコンドリア学会第12回年会
    • Place of Presentation
      筑波大学大学会館(つくば)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effects of mitochondrial oxidative stress induced by the complex II SDHC V69E mutation on infertility and habitual abortion2012

    • Author(s)
      Takamasa Ishii
    • Organizer
      The 2012 Cold Spring Harbor Laboratory meeting on Molecular Genetics of Aging
    • Place of Presentation
      Cold Spring Harbor Laboratory (NY)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 線虫C. elegansにおける紫外線感受性株rad-8のエネルギー代謝異常2012

    • Author(s)
      安田佳代
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学川内北キャンパス(仙台)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 低線量X線照射による線虫C. elegansの寿命延長機構の解析2012

    • Author(s)
      林政太朗
    • Organizer
      日本放射線影響学会第55回大会
    • Place of Presentation
      東北大学川内北キャンパス(仙台)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] The mev-1 models with an excess mitochondrial ROS for aging research2012

    • Author(s)
      Takamasa Ishii
    • Organizer
      International Symposium of Asian Association of Aging Research 2012 in Fukuoka -Biology of Aging and Disorders-
    • Place of Presentation
      Tsukushi-Kaikan/ Hotel Fukuoka Garden Palace (Fukuoka)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 低線量X線照射による線虫C. elegansの寿命延長機構の解析2012

    • Author(s)
      林政太朗
    • Organizer
      日本基礎老化学会第35回大会
    • Place of Presentation
      東邦大学習志野キャンパス(船橋)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミトコンドリア酸化ストレスによる不妊および習慣流産2012

    • Author(s)
      石井恭正
    • Organizer
      第65回日本酸化ストレス学会学術集会
    • Place of Presentation
      あわぎんホール(徳島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Mitochondrial Superoxide-accelerated Age-dependent Corneal Cell Dysfunctions2012

    • Author(s)
      Takamasa Ishii
    • Organizer
      2012 Spring Conference of the Korean Society for Gerontology and the 11th Korea-Japan Gerontologist Joint meeting
    • Place of Presentation
      Korean National Institute of Health (Osong)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 活性酸素過剰発生マウスTet-mev-1におけるCoQ10投与効果2011

    • Author(s)
      浅利真司, 他
    • Organizer
      第26回日本酸化ストレス学会関東支部会
    • Place of Presentation
      東京工科大学(東京都)
    • Year and Date
      2011-12-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 細胞内活性酸素種の生体への影響の解明2011

    • Author(s)
      石井恭正
    • Organizer
      2011年度日本放射線影響学会奨励賞受賞講演
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-18
    • Related Report
      2013 Final Research Report
  • [Presentation] 細胞内活性酸素種の生体への影響の解明2011

    • Author(s)
      石井恭正
    • Organizer
      2011年度日本放射線影響学会奨励賞受賞講演
    • Place of Presentation
      神戸商工会議所会館(兵庫県)(招待講演)
    • Year and Date
      2011-11-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of mitochondrial O_2 ・^- inducible complex IImutation on fertility and delivery in mev-1 mouse model2011

    • Author(s)
      Takamasa Ishii, et al
    • Organizer
      The 5th Biennial Meeting of SFRR-Asia, 8th Conference of ASMRM and 11th Conference of J-mit (The Winner of Young Investigator Award)
    • Place of Presentation
      Kagoshima, Japan
    • Year and Date
      2011-09-02
    • Related Report
      2013 Final Research Report
  • [Presentation] Effect of mitochondrial O_2^<.-> inducible complex II mutation on fertility and delivery in mev-1 mouse model2011

    • Author(s)
      Takamasa Ishii, et al
    • Organizer
      The 5^<th> Biennial Meeting of SFRR-Asia, 8^<th> Conference of ASMRM and 11^<th> Conference of J-mit (The winner of Young Investigator Award)
    • Place of Presentation
      Kagoshima Citizens' Culture Hall (Kagoshima)
    • Year and Date
      2011-09-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミトコンドリアとドライアイ2011

    • Author(s)
      内野裕一, 他
    • Organizer
      第16回シェーグレン症候群セミナー(日本シェーグレン症候群学会)
    • Place of Presentation
      HAKUYOHビル(東京都)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 角膜の細胞機能と疾患への酸化ストレスの影響2011

    • Author(s)
      尾内宏美, 他
    • Organizer
      第3回神奈川眼科学会(神奈川眼科医会)
    • Place of Presentation
      ホテルキャメロットジャパン(神奈川県)
    • Year and Date
      2011-04-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Oxidative stress-related diseases on aging in mitochondrial O_2^- inducible mev-1 models.2011

    • Author(s)
      Takamasa Ishii, et al.
    • Organizer
      The 1st Nagasaki-Pusan Joint Seminar on Aging Research
    • Place of Presentation
      Fukuoka
    • Year and Date
      2011-02-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Oxidative stress-related aging diseases involving mitochondrial O_2^<.-> inducible "mev-1" animal models2011

    • Author(s)
      Takamasa Ishii, et al
    • Organizer
      Metabolism and Disease at Cold Spring Harbor Laboratory Symposium
    • Place of Presentation
      Cold Spring Harbor Laboratory (NY)
    • Related Report
      2011 Annual Research Report
  • [Presentation] The Role Of Intracellular Oxidative Stress In The Mechanism Of The Dry Eye Disease2011

    • Author(s)
      Yuichi Uchino, et al
    • Organizer
      ARVO 2011 (The Association for Research in Vision and Ophthalmology)
    • Place of Presentation
      Greater Fort Lauderdale/Broward County Convention Center (FL)
    • Related Report
      2011 Annual Research Report
  • [Presentation] ミトコンドリア電子伝達系複合体II SDHC^<V69E>変異による酸化ストレス発生の不妊と習慣流産への影響2011

    • Author(s)
      石井恭正, 他
    • Organizer
      日本放射線影響学会第54回大会
    • Place of Presentation
      神戸商工会議所会館(兵庫県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 電子伝達系複合体II SDHCサブユニットV69Eアミノ酸点変異の不妊症・習慣流産への影響2011

    • Author(s)
      石井恭正, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会館(京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of Mitochondrial Superoxide anion (O_2^-) on Corneal cell functions in Tet-mev-1 transgenic mice.2010

    • Author(s)
      Hiromi Onouchi, et al.
    • Organizer
      XIX Biennial meeting of International Society for Eye Research
    • Place of Presentation
      Montreal, Canada
    • Year and Date
      2010-07-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of mitochondrial oxidative stress on decrease pregnancy rate, fertility rate, and birthweight.2010

    • Author(s)
      Takamasa Ishii, et al.
    • Organizer
      The 10^<th> Korea-Japan Gerontologist Joint Meeting
    • Place of Presentation
      DaeJeon, Korea
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitochondrial A-Raf drives neuronal differentiation via mitochondrial superoxide production by NGF stimulation in PC12 cells.2010

    • Author(s)
      Masaki Miyazawa, et al.
    • Organizer
      The 10^<th> Korea-Japan Gerontologist Joint Meeting
    • Place of Presentation
      DaeJeon, Korea
    • Year and Date
      2010-07-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of mitochondrial oxidative stress on corneal cell functions and diseases in Tet-mev-1 cells.2010

    • Author(s)
      Hiromi Onouchi, et al.
    • Organizer
      日本基礎老化学会第33回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミトコンドリア活性酸素が海馬依存的学習・記憶能力に及ぼす影響2010

    • Author(s)
      柳原倫太郎, 他
    • Organizer
      日本基礎老化学会第33回大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-06-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] A New Mouse Model Of Age-Related Ocular Disease (Tet-mev-1 Transgenic Mice) : Oxidative Stress-induced Ocular Change.2010

    • Author(s)
      Hiromi Onouchi, et al.
    • Organizer
      ARVO (The Association for Research in Vision and Ophthalmology) 2010
    • Place of Presentation
      FL, USA
    • Year and Date
      2010-05-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of mitochondrial oxidative stress by complex II SDHC V69E mutation on decreased fertility, pregnancy and delivery rates.2010

    • Author(s)
      Takamasa Ishii, et al.
    • Organizer
      Mitochondria, Life and Intervention 2010, The 7th Conference of ASMRM and 10th Conference of J-mit
    • Place of Presentation
      Fukuoka
    • Related Report
      2010 Annual Research Report
  • [Presentation] 加齢性疾患におけるミトコンドリアから生じる酸化ストレスの役割2010

    • Author(s)
      石井直明, 他
    • Organizer
      第33回日本分子生物学会年会&第83回日本生化学会大会合同大会BMB2010,ワークショップ「長寿科学の最前線-ヒト長寿科学と基礎老化科学の融合を目指して」
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitochondrial A-RAF drives neuronal differentiation via superoxide production and PDC activation in mitochondria.2010

    • Author(s)
      Masaki Miyazawa, et al.
    • Organizer
      Mitochondria, Life and Intervention 2010, The 7th Conference of ASMRM and 10th Conference of J-mit
    • Place of Presentation
      Fukuoka
    • Related Report
      2010 Annual Research Report
  • [Presentation] Effects of mitochondrial oxidative stress on decreased pregnancy and fertility rates.2010

    • Author(s)
      Takamasa Ishii, et al.
    • Organizer
      Molecular Genetics of Aging at Cold Spring Harbor Laboratory Meeting
    • Place of Presentation
      NY, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] A NEW MOUSE MODEL OF DRY EYE DISEASE (Tet-mev-1 Mice) : OXIDATIVE STRESS AFFECT FUNCTIONAL DECLINE IN LACRIMAL GLAND.2010

    • Author(s)
      Yuichi Uchino, et al.
    • Organizer
      The 6th International Conference on the Tear Film & Ocular Surface
    • Place of Presentation
      Florence, Italy
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mitochondrial A-Raf drives neuronal differentiation via mitochondrial superoxide production in PC12 cells.2010

    • Author(s)
      Masaki Miyazawa, et al.
    • Organizer
      第33回日本分子生物学会年会&第83回日本生化学会大会合同大会BMB2010
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミトコンドリア酸化ストレスの不妊症と低出生体重児出産への影響2010

    • Author(s)
      石井恭正, 他
    • Organizer
      日本放射線影響学会第53回大会
    • Place of Presentation
      京都
    • Related Report
      2010 Annual Research Report
  • [Presentation] ミトコンドリア機能不全と老化

    • Author(s)
      石井恭正
    • Organizer
      NPO法人国際医科学研究会第7回フォーラム「生物活性物質とミトコンドリア」
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Mitochondrial oxidative stress-inducible mev-1 models for aging research

    • Author(s)
      Takamasa Ishii
    • Organizer
      Molecular and Cellular Biology of Aging, The 34th Japan Society for Biomedical Gerontology Symposium and Micro-Nano Global COE
    • Place of Presentation
      Nagoya University School of Medicine (Nagoya)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Remarks] 東海大学医学部基礎医学系分子生命科学石井研究室(ホームページ等)

    • URL

      http://mls.med.u-tokai.ac.jp/jp/index.htm

    • Related Report
      2013 Final Research Report
  • [Remarks] 東海大学医学科伊勢原キャンパス石井恭正(ホームページ等)

    • URL

      http://kyousho.pr.tokai.ac.jp/index.php?p=s&yyg_shoc=030066&tsc_shoc=&cmp_sho_kubun_cd=100&yyg_bu_cd=2230&yyg_kyoinc=261474

    • Related Report
      2013 Final Research Report
  • [Remarks] 東海大学医学部 基礎医学系分子生命科学 石井研究室

    • URL

      http://mls.med.u-tokai.ac.jp/jp/index.htm

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東海大学医学科伊勢原キャンパス 石井恭正

    • URL

      http://kyousho.pr.tokai.ac.jp/index.php?p=s&yyg_shoc=030066&tsc_shoc=&cmp_sho_kubun_cd=100&yyg_bu_cd=2230&yyg_kyoinc=261474

    • Related Report
      2013 Annual Research Report
  • [Remarks] 東海大学医学部 基礎医学系分子生命科学 石井研究室

    • URL

      http://mls.med.u-tokai.ac.jp/jp/index.htm

    • Related Report
      2012 Annual Research Report
  • [Remarks] 東海大学医学科伊勢原キャンパス 石井恭正

    • URL

      http://kyousho.pr.tokai.ac.jp/index.php?p=s&yyg_shoc=030066&tsc_shoc=&cmp_sho_kubun_cd=100&yyg_bu_cd=2230&yyg_kyoinc=261474

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://kyousho.pr.tokai.ac.jp/index.php?p=s&yyg_shoc=030066&tsc_shoc=&cmp_sho_kubun_cd=100&yyg_bu_cd=2230&yyg_kyoinc=261474

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://prog.pr.tokai.ac.jp/utokai/TkpJin?p_kubun=01&p_shoc=030066&p_kyoushoc=261474

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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