| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2010: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Research Abstract |
In this study, we focused on age-related diseases with oxidative stress. The age-dependent alterations of tissue functions caused by oxidative stress were analyzed in mitochondrial reactive oxygen species (ROS)-inducible model Tet-mev-1 mice. In the results, 1) low-birth-weight infants, 2) accelerated age-related corneal dysfunctions with dry eyes by lacrimal gland inflammations, 3) glial environmental defects in hippocampal regions with age, 4) recurrent abortions and maternal death, and 5) chronic hyperglycemia were confirmed as aging phenomena caused by mitochondrial oxidative stress. It was expecting that a means would be demonstrated to suppress the age-dependent homeostatic unbalanced alterations in individuals, when these molecular mechanisms would be clarified in this mouse model.
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