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The role of natural helper cells during helminth infection.

Research Project

Project/Area Number 22689013
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Parasitology (including Sanitary zoology)
Research InstitutionKeio University

Principal Investigator

MORO Kazuyo  慶應義塾大学, 医学部, 特任助教(非常勤) (90468489)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2011: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2010: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Keywordsナチュラルヘルパー細胞 / 寄生虫感染 / IL-33 / IL-25 / Th2サイトカイン / 好酸球浸潤 / 肺 / ケモカイン受容体 / Th2
Research Abstract

Natural helper(NH) cells, which we reported to be novel innate lymphoid cell, proliferated and produced IL-5, IL-13 and eotaxin in response to IL-33 or the combination of IL-2 and IL-25(IL-2+IL-25). While naive NH cells expressed CCR2, IL-33 or IL-2+IL-25 stimulation downregulated CCR2 and induced CCR4, enabling NH cells to migrate to the lung. These cells do not migrate to lymph nodes or express MHC class II, and are distinct from other T_H2-type innate lymphocytes present in lymph nodes shch as nuocyte. Although Nippostrongylus brasiliensis infection or intratracheal administration of IL-33 or IL-2+IL-25 failed to induce lung eosinophilia in・_c^<-/-> Rag-2^<-/-> mice lacking NH cells, adoptive transfer of NH cells restored the accumulation of CCR4^+NH cells and eosinophilia in the lung. NH cells thus play an important role by inducing goblet cell hyperplasia and eosinophilia in the lung during helminth infection.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (34 results)

All 2012 2011 2010 2009

All Journal Article (7 results) Presentation (19 results) Book (8 results)

  • [Journal Article] Natural "Helper" Cells in the Lung : Good or Bad Help?2012

    • Author(s)
      Shigeo Koyasu, Kazuyo Moro
    • Journal Title

      Immunity

      Volume: 36(23) Issue: 3 Pages: 317-319

    • DOI

      10.1016/j.immuni.2012.03.001

    • Related Report
      2011 Final Research Report
  • [Journal Article] Innate Th2-type immune responses and the natural helper cell, a newly identified lymphocyte population2011

    • Author(s)
      Shigeo Koyasu, Kazuyo Moro
    • Journal Title

      Curr Opin Allergy Clin Immunol.

      Volume: 11 Issue: 2 Pages: 109-14

    • DOI

      10.1097/aci.0b013e3283448808

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Type 2 innate immune responses and the natural helper cell2011

    • Author(s)
      Shigeo Koyasu, Kazuyo Moro
    • Journal Title

      Immunology

      Volume: 132 Issue: 4 Pages: 475-81

    • DOI

      10.1111/j.1365-2567.2011.03413.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Innate Th2-type immune responses and the natural helper cell, a newly identified lymphocyte population.2011

    • Author(s)
      Koyasu S
    • Journal Title

      Curr Opin Allergy Clin Immunol.

      Volume: 11 Pages: 109-14

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Type 2 innate immune responses and the natural helper cell.2011

    • Author(s)
      Koyasu S
    • Journal Title

      Immunology.

      Volume: 132 Pages: 475-81

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Natural helper cells : a new player in the innate immune response against helminth infection2010

    • Author(s)
      Shigeo Koyasu, Kazuyo Moro, Tanabe Masanobu, Takeuchi Tutomu
    • Journal Title

      Adv. Immunol.

      Volume: 108 Pages: 21-44

    • Related Report
      2011 Final Research Report
  • [Journal Article] Natural helper cells : a new player in the innate immune response against helminth infection.2010

    • Author(s)
      Koyasu S
    • Journal Title

      Adv Immunol.

      Volume: 108 Pages: 21-44

    • Related Report
      2010 Annual Research Report
  • [Presentation] Th2-type innate immune responses and the natural helper cell2012

    • Author(s)
      Kazuyo Moro, Shigeo Koyasu
    • Organizer
      The 4th Stage Surface Barrier Immunology Group(SBARIS) 3rd Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2012-03-24
    • Related Report
      2011 Final Research Report
  • [Presentation] ナチュラルヘルパー細胞のTh2型免疫応答2012

    • Author(s)
      茂呂和世
    • Organizer
      第8回宮崎サイエンスキャンプ
    • Place of Presentation
      宮崎
    • Year and Date
      2012-02-18
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-25 and IL-33 induced innate Th1-type immune responses of natural helper cell2011

    • Author(s)
      Kazuyo Moro, Shigeo Koyasu
    • Organizer
      第40回日本免疫学会総会・学術集会記録
    • Place of Presentation
      幕張
    • Year and Date
      2011-11-27
    • Related Report
      2011 Final Research Report
  • [Presentation] IL-25やIL-33によって誘導される肺のナチュラルヘルパー細胞の機能解析2011

    • Author(s)
      茂呂和世
    • Organizer
      第61回日本アレルギー学会秋期学術大会
    • Place of Presentation
      東京(グランドプリンスホテル新高輪)(招待講演)
    • Year and Date
      2011-11-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺におけるナチュラルヘルパー細胞の好酸球誘導機構2011

    • Author(s)
      茂呂和世、古賀諭、小安重夫
    • Organizer
      第23回高遠・分子細胞生物学シンポジウム
    • Place of Presentation
      高遠
    • Year and Date
      2011-08-25
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺におけるナチュラルヘルパー細胞の好酸球誘導機構2011

    • Author(s)
      茂呂和世
    • Organizer
      第23回高遠・分子細胞生物学シンポジウム
    • Place of Presentation
      長野(高遠さくらホテル)
    • Year and Date
      2011-08-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nippostrongylus brasiliensis感染におけるナチュラルヘルパー細胞の機能解析2011

    • Author(s)
      古賀諭、茂呂和世、田邊将信、竹内勤、小安重夫
    • Organizer
      第80回日本寄生虫学会大
    • Place of Presentation
      東京
    • Year and Date
      2011-07-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Nippostrongylus brasiliensis感染におけるナチュラルヘルパー細胞の機能解析2011

    • Author(s)
      古賀諭
    • Organizer
      第80回日本寄生虫学会大会
    • Place of Presentation
      東京(東京慈恵会医科大学)
    • Year and Date
      2011-07-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Th2-type innate immune responses and the natural helper cell2011

    • Author(s)
      Kazuyo Moro, Shigeo Koyasu
    • Organizer
      15th International Congress of Mucosal Immunology
    • Place of Presentation
      Paris
    • Year and Date
      2011-07-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Th2-type innate immune responses and the natural helper cell2011

    • Author(s)
      Kazuyo Moro
    • Organizer
      15th International Congress of Mucosal Immunology
    • Place of Presentation
      Paris (Universite Paris Descartes)
    • Year and Date
      2011-07-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] ナチュラルヘルパー細胞のアレルギー性喘息における役割2011

    • Author(s)
      茂呂和世、小安重夫
    • Organizer
      Kyoto T Cell Conference第21回学術集会
    • Place of Presentation
      京都
    • Year and Date
      2011-06-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 自然免疫機構におけるナチュラルヘルパー細胞の役割2011

    • Author(s)
      茂呂和世
    • Organizer
      第9回感染症沖縄フォーラム
    • Place of Presentation
      沖縄
    • Year and Date
      2011-02-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of natural helper cell in helminth infection2010

    • Author(s)
      Kazuyo Moro
    • Organizer
      Awaji International Forum on Infection and Immunity
    • Place of Presentation
      Awaji
    • Year and Date
      2010-09-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脂肪組織に存在する新しいリンパ球ナチュラルヘルパー細胞の役割2010

    • Author(s)
      茂呂和世
    • Organizer
      第3回Sumphony
    • Place of Presentation
      東京
    • Year and Date
      2010-09-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Innate production of Th2 cytokines by adipose tissue-associated natural helper cell2010

    • Author(s)
      Kazuyo Moro
    • Organizer
      14th International Congress Of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] ナチュラルヘルパー細胞のTh2サイトカイン産生による自然免疫誘導機構2010

    • Author(s)
      茂呂和世
    • Organizer
      第31回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2010-08-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新たに発見したリンパ球ナチュラルヘルパー細胞、自己免疫疾患研究会2010

    • Author(s)
      茂呂和世
    • Organizer
      自己免疫疾患研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新しいリンパ球ナチュラルヘルパー細胞のNippostrongylus brasiliensis感染における役割2010

    • Author(s)
      茂呂和世
    • Organizer
      日本寄生虫学会大会
    • Place of Presentation
      旭川
    • Year and Date
      2010-05-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Innate production of Th2 cytokines by adipose tissue-associated c-Kit^+Sca-1^+ lymphocytes2009

    • Author(s)
      Kazuyo Moro
    • Organizer
      The American Association of Immunologists
    • Place of Presentation
      Baltimore
    • Year and Date
      2009-12-02
    • Related Report
      2010 Annual Research Report
  • [Book] 細胞工学2011

    • Author(s)
      茂呂和世、小安重夫
    • Publisher
      秀潤社
    • Related Report
      2011 Final Research Report
  • [Book] BIO Clinica2010

    • Author(s)
      茂呂和世、小安重夫
    • Publisher
      北隆館
    • Related Report
      2011 Final Research Report
  • [Book] 医学のあゆみ2010

    • Author(s)
      茂呂和世、小安重夫
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2011 Final Research Report
  • [Book] 実験医学2010

    • Author(s)
      茂呂和世、小安重夫
    • Publisher
      羊土社
    • Related Report
      2011 Final Research Report
  • [Book] ファルマシア2010

    • Author(s)
      茂呂和世、小安重夫
    • Publisher
      日本薬学会
    • Related Report
      2011 Final Research Report
  • [Book] 分子消化器病2010

    • Author(s)
      茂呂和世、小安重夫
    • Publisher
      先端医学社
    • Related Report
      2011 Final Research Report
  • [Book] 臨床免疫・アレルギー2010

    • Author(s)
      茂呂和世、小安重夫
    • Publisher
      科学評論社
    • Related Report
      2011 Final Research Report
  • [Book] 感染炎症免疫2010

    • Author(s)
      茂呂和世、小安重夫
    • Publisher
      医薬の門社
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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