Spatial immunological network at mucosal immune system
| Project/Area Number |
22689015
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Immunology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
JUN Kunisawa 東京大学, 医科学研究所, 准教授 (80376615)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2011: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Fiscal Year 2010: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
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| Keywords | 粘膜免疫 / イメージング / 感染症 |
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| Research Abstract |
In this study, we performed an immunological studies using some imaging system for analyzing bacterial distribution and growth as well as host immune system at mucosal tissues. Using chemiluminescence-based microbial detection system, we can evaluate nasal vaccine effects against Streptococcus pneumoniae. As host immune system, we identified M cell-like cells in the epithelial cell layer of the nasal cavity as a new pathogen uptake pathway. In addition, macro-confocal laser microscopy allowed us to reveal the unique dendritic cell function in the formation of T cell areas in the Peyer's patches by regulating the retention rather than entering step of T cells in the Peyer's patches. Taken together, our imaging systems reveal the novel immunological functions and bacterial distribution and growth, which can be applied to the basic immunological analyses and the evaluation of mucosal vaccines.
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Report
(3 results)
Research Products
(64 results)
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[Journal Article] Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation2012
Author(s)
S. Takagi, Y. Saito, A. Hijikata, S.Tanaka, T. Watanabe, T. Hasegawa, S. Mochizuki, J. Kunisawa, H. Kiyono, H. Koseki, O. Ohara, T. Saito, S. Taniguchi, L. D. Shultz, F. Ishikawa
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Journal Title
Blood
Volume: 119
Pages: 2768-77
Related Report
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[Journal Article] The airway antigen sampling system: respiratory M cells as an alternative gateway for inhaled antigens2011
Author(s)
D. Y., Kim, A. Sato, S. Fukuyama, H.Sagara, T. Nagatake, I. G. Kong, K. Goda, T. Nochi, J. Kunisawa, S. Sato, Y. Yokota, C. H. Lee, and H. Kiyono
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Journal Title
J Immunol
Volume: 186
Pages: 4253-62
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[Journal Article] Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus2010
Author(s)
H. Kayamuro, Y. Yoshioka, Y. Abe, S.Arita, K. Katayama, T. Nomura, T. Yoshikawa, R. Kubota-Koketsu, K. Ikuta, S. Okamoto, Y. Mori, J. Kunisawa, H. Kiyono, N. Itoh, K. Nagano, H. Kamada, Y. Tsutsumi, S.I. Tsunoda
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Journal Title
J Virol
Volume: 84
Pages: 12703-12
Related Report
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[Journal Article] Indigenous opportunistic bacteria inhabit mammalian gut-associated lymphoid tissues and share a mucosal antibody-mediated symbiosis2010
Author(s)
T. Obata, Y. Goto, J. Kunisawa, S. Sato, M. Sakamoto, H. Setoyama, T. Matsuki,K. Nonaka, N. Shibata, M. Gohda, Y. Kagiyama, T. Nochi, Y. Yuki, Y. Fukuyama, A. Mukai, S. Shinzaki, K. Fujihashi, C. Sasakawa, H. Iijima, M. Goto, Y. Umesaki, Y. Benno, and H. Kiyono
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Journal Title
Proc Natl Acad Sci USA
Volume: 107
Pages: 7419-24
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