Genome tailor-made evaluation of gout risk by molecular epidemiologic analysis toward early prevention of gout
| Project/Area Number |
22689021
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | National Defense Medical College |
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Principal Investigator |
MATSUO Hirotaka 防衛医科大学校, 医学教育部医学科専門課程, 講師 (00528292)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Keywords | 分子遺伝疫学 / 予防医学 / 個人差医療 / 尿酸 / 遺伝統計学 / 個人差医療に基づく予防医学 |
|---|
| Research Abstract |
In this study, we collected genome samples and clinical information from gout/hyperuricemia cases and controls. As a case only study, we genotyped 644 hyperuricemia patients for ABCG2 dysfunctional variants, which revealed that “decrease of extra-renal urate excretion is a common cause of hyperuricemia”（Nature Communications, 2012）. In addition, a genome wide association study of gout is also ongoing with the support of the Grant-in-Aid for Scientific Research on Innovative Areas ”Genome Sciences”. So far, we obtained several positive data by preliminary analysis, and we convince ourselves that we will report on the important gout susceptible genes soon.
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Report
(4 results)
Research Products
(150 results)
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[Journal Article] Decreased extra-renal urate excretion is a common cause of hyperuricemia2012
Author(s)
K.Ichida, H.Matsuo. T.Takada, A.Nakayama, K.Murakami, T.Shimizu, Y.Yamanashi, H.Kasuga, H.Nakashima, T.Nakamura, Y.Takada, Y.Kawamura, H.Inoue, C.Okada, Y.Utsumi, Y.Ikebuchi, K.Ito, M.Nakamura, Y.Shinohara, M.Hosoyamada, Y.Sakurai, N.Shinomiya, T.Hosoya, H.Suzuki
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Journal Title
Nat Commun
Volume: (in press)
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Peer Reviewed
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[Journal Article] Identification of ABCG2 dysfunction as a major factor contributing to gout2011
Author(s)
H.Matsuo, T.Takada, K.Ichida, T.Nakamura, A.Nakayama, Y.Takada, C.Okada, Y.Sakurai, T.Hosoya, Y.Kanai, H.Suzuki, N.Shinomiya
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Journal Title
Nucleosides Nucleotides Nucleic Acids
Volume: 30
Issue: 12
Pages: 1098-1104
DOI
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Peer Reviewed
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[Presentation] Changes in uric acid levels with dysfunctional ABCG2 and novel pathophysiological model of hyperuricemia2012
Author(s)
Akiyoshi Nakayama, Hirotaka Matsuo, Kimiyoshi Ichida, Tappei Takada, Yuzo Takada, Hiroshi Nakashima, Takahiro Nakamura, Yutaka Sakurai, Nobuyuki Hamajima, Hiroshi Suzuki, Nariyoshi Shinomiya
Organizer
4th FEBS special Meeting (ABC2012)
Place of Presentation
Innsbruck, Austria
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[Presentation] ABCG2 is a major causative gene for gout2011
Author(s)
H.Matsuo, T.Takada, K.Ichida, T.Nakamura, A.Nakayama, T.Chiba, Y.Takada, H.Inoue, Y.Kawamura, Y.Utsumi, K.Suzuki, S.Watanabe, Y.Sakurai, T.Hosoya, H.Suzuki, N.Hamajima, N.Shinomiya
Organizer
the 1st Symposium of Asia Pacific League of Associations for Rheumatology
Place of Presentation
Taipei, Taiwan
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[Presentation] Molecular pathogenesis for paroxysmal involuntary movements as a channelopathy : genetic analysis of human cases and an animal model2011
Author(s)
H.Matsuo. C.Okada, S.E.Sander, M.Hamann, A.Richter, T.Hamada, A.Nakayama, Y.Utsumi, Y.Kawamura, H.Onoue, K.Kaida, Y.Kobayashi, K. Kamakura, N.Shinomiya
Organizer
2011 International congress of human genetics
Place of Presentation
Montreal, Canada
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[Presentation] 発作性ジストニー性舞踊アテトーゼの病因分子の探索;家系症例と疾患モデル動物の遺伝学的解析2011
Author(s)
松尾洋孝, 岡田千沙, 濱田剛, 中山昌喜, 内海由貴, 河村優輔, 尾上裕行, 海田賢一, 守本祐司, 小林靖, 鎌倉恵子, 四ノ宮成祥
Organizer
第56回日本人類遺伝学会・第11回東アジア人類遺伝学会
Place of Presentation
千葉
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[Presentation] 痛風の主要病因遺伝子ABCG2の同定と分子遺伝疫学的解析2011
Author(s)
松尾洋孝, 高田龍平, 市田公美, 中村好宏, 中島宏, 中山昌喜, 井上寛規, 高田雄三, 若井建志, 内藤真理子, 細谷龍男, 鈴木洋史, 櫻井裕, 浜島信之, 四ノ宮成祥
Organizer
第21回日本疫学会学術総会
Place of Presentation
札幌
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[Presentation] 痛風の主要病因遺伝子ABCG2の臨床遺伝学的解析2011
Author(s)
松尾洋孝, 市田公美, 清水徹, 高田龍平, 中村好宏, 中山昌喜, 高田雄三, 井上寛規, 櫻井裕, 金井好克, 鈴木洋史, 浜島信之, 細谷龍男, 四ノ宮成祥
Organizer
第44回日本痛風・核酸代謝学会総会
Place of Presentation
東京
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[Presentation] ABCG2/BCRP as a major cause for gout2011
Author(s)
Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Hiroshi Suzuki, Tatsuo Hosoya, Nariyoshi Shinomiya
Organizer
14th International Symposium on Purine and Pyrimidine Metabolism in Man, PP 11
Place of Presentation
Tokyo(招待講演)
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[Presentation] Identification of ABCG2 as a major cause for gout2011
Author(s)
Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Akiyoshi Nakayama, Yuzo Takada, Yutaka Sakurai, Tatsuo Hosoya, Yoshikatsu Kanai, Hiroshi Suzuki, Nariyoshi Shinomiya
Organizer
14th International Symposium on Purine and Pyrimidine Metabolism in Man, PP 11
Place of Presentation
Tokyo
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[Presentation] ABCG2 is a high-capacity urate transporter and its genetic impairment increase serum uric acid levels in humans2011
Author(s)
Akiyoshi Nakayama, Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Yuki Ikebuchi, Kousei Ito, Tatsuo Hosoya, Yoshikatsu Kanai, Hiroshi Suzuki, Nariyoshi Shinomiya
Organizer
14th International Symposium on Purine and Pyrimidine Metabolism in Man, PP11
Place of Presentation
Tokyo
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[Presentation] Pathogenic GLUT9 mutations causing renal hypouricemia type 2 (RHUC2)2011
Author(s)
Yusuke Kawamura, Hirotaka Matsuo, Toshinori Chiba, Shushi Nagamori, Akiyoshi Nakayama, Hiroki Inoue, Yoshitaka Utsumi, Takashi Oda, Junichiro Nishiyama, Yoshikatsu Kanai, Nariyoshi Shinomiya
Organizer
14th International Symposium on Purine and Pyrimidine Metabolism in Man, PP 11
Place of Presentation
Tokyo
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[Presentation] Molecular mechanism of urate reabsorption and excretion in humans2010
Author(s)
Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Akiyoshi Nakayama, Yuki Ikebuchi, Kousei Ito, Yuzo Takada, Hiroki Inoue, Yutaka Sakurai, Tatsuo Hosoya, Hiroshi Suzuki, Nariyoshi Shinomiya
Organizer
第87回日本生理学会大会
Place of Presentation
盛岡
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[Presentation] 痛風の主要病因遺伝子ABCG2/BCRPの同定2010
Author(s)
松尾洋孝, 高田龍平, 市田公美, 中村好宏, 中山昌喜, 高田雄三, 井上寛規, 櫻井裕, 細谷龍男, 金井好克, 鈴木洋史, 四ノ宮成祥
Organizer
日本人類遺伝学会第55回大会
Place of Presentation
大宮
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[Presentation] 痛風の主要病因遺伝子の探索と同定2010
Author(s)
松尾洋孝, 高田龍平, 市田公美, 中村好宏, 中山昌喜, 池淵祐樹, 伊藤晃成, 高田雄三, 井上寛規, 河村優輔, 内海由貴, 櫻井裕, 細谷龍男, 金井好克, 鈴木洋史, 四ノ宮成祥
Organizer
BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会 合同大会)
Place of Presentation
神戸
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[Presentation] (学会賞・受賞)ABCG2/BCRP is a high-capacity urate transporter and its common variant increases serum uric acid levels in humans2010
Author(s)
Akiyoshi Nakayama, Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Yuki Ikebuchi, Kousei Ito, Tatsuo Hosoya, Yoshikatsu Kanai, Hiroshi Suzuki, Nariyoshi Shinomiya
Organizer
Gordon Research Conference on Membrane Transport Proteins
Place of Presentation
Biddeford, ME, USA
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[Presentation] Pathogenic GLUT9 mutations in renal hypouricemia type 2, Gordon Research Conference on Membrane Transport Proteins2010
Author(s)
Yusuke Kawamura, Hirotaka Matsuo, Toshinori Chiba, Shushi Nagamori, Akiyoshi Nakayama, Hiroki Inoue, Hideharu Domoto, Yuichi Kikuchi, Takashi Oda, Junichiro Nishiyama, Yoshikatsu Kanai, Nariyoshi Shinomiya
Organizer
Gordon Research Conference on Membrane Transport Proteins
Place of Presentation
Biddeford, ME, USA
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[Presentation] ABCG2/BCRP encodes a high-capacity urate transporter and its common variant increases serum uric acid levels in humans2010
Author(s)
Hiroki Inoue, Hirotaka Matsuo, Tappei Takada, Kimiyoshi Ichida, Takahiro Nakamura, Akiyoshi Nakayama, Koji Suzuki, Tatsuo Hosoya, Hiroshi Suzuki, Nobuyuki Hamajima, Nariyoshi Shinomiya
Organizer
2010 American Society of Human Genetics Annual Meeting
Place of Presentation
Washington DC, USA
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[Book] 細胞工学2012
Author(s)
松尾洋孝, 市田公美, 高田龍平, 中山昌喜, 四ノ宮成祥
Publisher
秀潤社(印刷中)
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[Book] 実験医学2010
Author(s)
松尾洋孝, 高田龍平, 市田公美, 中村好宏, 鈴木洋史, 四ノ宮成祥
Total Pages
5
Publisher
羊土社
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