| Budget Amount *help |
¥23,790,000 (Direct Cost: ¥18,300,000、Indirect Cost: ¥5,490,000)
Fiscal Year 2012: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2011: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2010: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Research Abstract |
In this study, we collected genome samples and clinical information from gout/hyperuricemia cases and controls. As a case only study, we genotyped 644 hyperuricemia patients for ABCG2 dysfunctional variants, which revealed that “decrease of extra-renal urate excretion is a common cause of hyperuricemia”（Nature Communications, 2012）. In addition, a genome wide association study of gout is also ongoing with the support of the Grant-in-Aid for Scientific Research on Innovative Areas ”Genome Sciences”. So far, we obtained several positive data by preliminary analysis, and we convince ourselves that we will report on the important gout susceptible genes soon.
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