Elucidation of the mechanism of in vivo ketogenesis by astrocytes

• Project/Area Number: 22689028
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Neurology
• Research Institution: Keio University
• Principal Investigator: NAKAHARA Jin 慶應義塾大学, 医学部, 特任講師 (60537950)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000); Fiscal Year 2012: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000); Fiscal Year 2010: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
• Keywords: 神経分子病態学 / 脳代謝 / アストロサイト / ケトン体 / 遺伝子改変マウス / HMGCS2 / Conditionl KOマウス

Research Abstract

Regulation of brain metabolism is critical in the treatment or prevention of neurological diseases or in future regenerative medicine in central nervous system. Recently, ketone bodies were shown to have a pivotal role in brain metabolism and act as a neu

Research Products

• [Journal Article] Current concepts in multiple sclerosis : autoimmunity versus oligodendrogliopathy (2012)
  • Author(s): Nakahara J, Maeda M, Aiso S, Suzuki N
  • Journal Title: Clin Rev Allergy Immunol Volume: 42 Issue: 1 Pages: 26-34
  • DOI: 10.1007/s12016-011-8287-6
  • Peer Reviewed
• [Journal Article] Autoimmunity versus oligodendrogliopathy: The pathogenesis of multiple sclerosis. (2010)
  • Author(s): Jin Nakahara, Sadakazu Aiso, Norihiro Suzuki.
  • Journal Title: Arch Immunol Ther Exp Volume: 58 Pages: 325-333
  • Peer Reviewed
• [Presentation] 髄鞘化を促進する髄鞘脂質前駆体の探索-多発性硬化症の新規治療戦略開発を目指して (2013)
  • Author(s): 中原仁
  • Organizer: 第54回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 髄鞘化を促進する髄鞘脂質前駆体の探索－多発性硬化症の新規治療戦略開発を目指して (2013)
  • Author(s): 中原仁
  • Organizer: 第54回日本神経学会学術大会
  • Place of Presentation: 東京
• [Presentation] Novel experimental remyelination therapy for multiple sclerosis (2012)
  • Author(s): Jin Nakahara
  • Organizer: Pan-Asian Congress on Treatment and Research in Multiple Sclerosis
  • Place of Presentation: 中国・北京
• [Presentation] オリゴデンドロサイトパチーと新たな髄鞘再生戦略 (2012)
  • Author(s): 中原仁
  • Organizer: 第53回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] Novel experimental remyelination therapy for multiple sclerosis (2012)
  • Author(s): Jin Nakahara
  • Organizer: 5th Pan-Asian Congress on Treatment and Research in Multiple Sclerosis
  • Place of Presentation: 中国・北京
  • Invited
• [Presentation] オリゴデンドロサイトパチーと新たな髄鞘再生戦略 (2012)
  • Author(s): 中原仁
  • Organizer: 第53回日本神経学会学術大会
  • Place of Presentation: 東京
  • Invited
• [Presentation] Research for the development of central nervous system remyelination medicines (2011)
  • Author(s): 中原仁
  • Organizer: 第88回日本生理学大会・第116回日本解剖学会総会全国区術集会 合同大会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2011-03-29
• [Presentation] Research for the development of central nervous system remyelination medicines (2011)
  • Author(s): 中原仁
  • Organizer: 第88回日本生理学大会/第116回日本解剖学会総会・全国学術集会合同大会
  • Place of Presentation: 横浜
• [Presentation] オリゴデンドロサイト前駆細胞の分化促進抗体による中枢神経系髄鞘再生誘導の試み (2011)
  • Author(s): 中原仁
  • Organizer: 第52回日本神経学会学術大会
  • Place of Presentation: 名古屋
• [Presentation] Induced maturation of oligodendrocytes and promotion of remyelination by FcRgamma-targeting monoclonal antibody (2011)
  • Author(s): Jin Nakahara
  • Organizer: 5th Joint Triennial Congress of the European and Americas Committee for Treatment and Research in Multiple Sclerosis
  • Place of Presentation: オランダ
• [Presentation] Blueprint for the development of remyelination medicines for multiple sclerosis (2010)
  • Author(s): 中原仁
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2010-05-21
• [Presentation] Why remyelination fails in multiple sclerosis and how could we overcome (2010)
  • Author(s): Jin Nakahara
  • Organizer: NeuroTalk 2010
  • Place of Presentation: シンガポール
• [Presentation] Blueprint for the development of remyelination medicines for multiple sclerosis (2010)
  • Author(s): 中原仁
  • Organizer: 第51回日本神経学会総会
  • Place of Presentation: 東京
• [Presentation] 多発性硬化症に対する髄鞘再生誘導抗体医薬の開発
  • Author(s): 中原仁
  • Organizer: 第2回創薬Innovation Forum
  • Place of Presentation: 東京
  • Invited
• [Remarks]
  • URL: http://www.careerpath-prj.keio.ac.jp/kanrinmaru/scholar/nakahara/
• [Remarks]
  • URL: http://www.careerpath-prj.keio.ac.jp/kanrinmaru/scholar/nakahara/