The mechanisms of recognition ofStreptococcus pneumoniae by innate lymphocytes
Project/Area Number |
22689031
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Infectious disease medicine
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
KINJO Yuki 国立感染症研究所, 生物活性物質部, 室長 (20570831)
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2010: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
Keywords | 感染症 / 内科 / 免疫学 / 細菌 / 脂質 |
Research Abstract |
Pneumonia is the third leading cause of death in Japan. The aim of this research project is to elucidate the mechanisms of host defense against Streptococcus pneumonia, the leading causative agent of pneumonia. We have found that a lymphocyte called NKT cell detects bacterial glycolipid antigen rapidly after S. pneumonia infection. Our data show that the recognition of glycolipid antigen by NKT cell is important for bacterial clearance. Furthermore, human NKT cells also respond to S. pneumonia glycolipid similar to mouse NKT cells. These data indicate that the recognition of bacterial glycolipid antigen by NKT cells plays an important role in the host defense against S. pneumonia infection.
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Report
(4 results)
Research Products
(19 results)
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[Presentation] Microbial glycolipid antigen recognition by invariant Natural killer T cells2011
Author(s)
Li Y, Girardi E, Yu ED, Wang J, Tarumoto N, Pei B, Painter GF, Illarionov PA, Kinjo Y, Kronenberg M, Zajonc DM
Organizer
The 6th International Symposium on CD1 and NKT
Place of Presentation
米国シカゴ
Year and Date
2011-09-24
Related Report
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[Presentation] Invariant NKT cells detect pathogenic Gram-positive bacteria2010
Author(s)
Yuki Kinjo, Petr Illarionov, Bo Pei, Jose Luis Vela, Enrico Girardi, Xiangming Li, Yali Li, Kazuyoshi Kawakami, Gurdyal S.Besra, Moriya Tsuji, Dirk M.Zajonc, Mitchell Kronenberg
Organizer
第14回国際免疫学会
Place of Presentation
兵庫県、神戸国際展示場
Year and Date
2010-08-23
Related Report
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