Development of Br-76-labeled amino acid derivatives for imaging tumors

• Project/Area Number: 22689035
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Chiba University (2011-2013); Gunma University (2010)
• Principal Investigator: HANAOKA Hirofumi 千葉大学, 薬学研究科(研究院), 助教 (50361390)
• Project Period (FY): 2010-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000); Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2011: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000); Fiscal Year 2010: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
• Keywords: がん / 診断 / 薬学 / 癌

Research Abstract

Br-76 is an attractive positron emitter due to its long half-life (t1/2=16.1 h). In this study, Br-76-labeled amino acid derivatives were designed, and their potential as a tumor imaging agent was evaluated.
Among several Br-76-labeled amino acid derivatives, 2-[Br-76]bromo-alpha-methyl L-phenylalanine (2-[Br]-AMP) exhibited preferred pharmacokinetics and tumor accumulation in vivo. These findings suggest that 2-[Br-76]-AMP would constitute a potential new PET tracer for tumor imaging.

Research Products

• [Journal Article] Biological evaluation of 3-[18F]fluoro-α-methyl-D-tyrosine (D-[18F]FAMT) as a novel amino acid tracer for positron emission tomography. (2013)
  • Author(s): Ohshima Y
  • Journal Title: Ann Nucl Med Volume: 27 Issue: 4 Pages: 314-324
  • DOI: 10.1007/s12149-013-0687-7
  • Peer Reviewed
• [Journal Article] Preparation and biological evaluation of 3-[76Br] bromo-α-methyl-L-tyrosine, a novel tyrosine analog for positron emission tomography imaging of tumors (2011)
  • Author(s): Ohshima Y, Hanaoka H, Watanabe S, Sugo Y, Watanabe S, Tominaga H, Oriuchi N, Endo K, Ishioka NS
  • Journal Title: Nucl Med Biol Volume: 38 Issue: 6 Pages: 857-865
  • DOI: 10.1016/j.nucmedbio.2011.02.001
  • Peer Reviewed
• [Journal Article] Preparation and biological evaluation of 3-[^<76>Br]bromo-α-methyl-L-tyrosine, a novel tyrosine analog for PET imaging of tumors (2011)
  • Author(s): Ohshima Y, et al
  • Journal Title: Nucl Med Biol Volume: (in press)
  • Peer Reviewed
• [Presentation] Development of ^<76>Br-labeled α-methyl L-phenylalanine for imaging tumors (2013)
  • Author(s): Hanaoka H, Watanabe S, Ohshima Y, Suzuki Y, Yamaguchi A, Uehara T, Ishioka NS, Tsushima Y, Endo K, Arano Y
  • Organizer: 2013 Society of Nuclear Medicine Annual Meeting
  • Place of Presentation: Vancouver, Canada
• [Presentation] Development of 76Br-labeled α-methyl L-phenylalanine for imaging tumors (2013)
  • Author(s): 花岡宏史
  • Organizer: 米国会医学会
  • Place of Presentation: バンクーバー (カナダ）
• [Presentation] 3-[^<76>Br]bromo-α-methyl-D-tyrosine の腫瘍PET イメージング薬剤としての有用性の評価 (2012)
  • Author(s): 大島康宏, 花岡宏史, 渡邉茂樹, 渡辺智, 須郷由美, 織内昇, 遠藤啓吾, 石岡典子
  • Organizer: 第52回日本核医学会総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-10-12
• [Presentation] 3‐[76Br]bromo‐α‐methyl‐D‐tyrosineの腫瘍PETイメージング薬剤としての有用性の評価 (2012)
  • Author(s): 大島康宏
  • Organizer: 第52回日本核医学会総会
  • Place of Presentation: 札幌市
• [Presentation] 3-[^<18>F]fluoro-α-methyl-D-tyrosine によるD 体アミノ酸トレーサーの低腎集積機構の検討 (2011)
  • Author(s): 大島康宏, 花岡宏史, 富永英之, 渡邉茂樹, 織内昇, 遠藤啓吾, 石岡典子
  • Organizer: 第51回日本核医学会総会
  • Place of Presentation: つくば
  • Year and Date: 2011-10-28
• [Presentation] 3-[^<18>F]Fluoro-α-methyl-D-tyrosineによるD体アミノ酸トレーサーの低腎集積機構の検討 (2011)
  • Author(s): 大島康宏
  • Organizer: 第51回日本核医学会総会
  • Place of Presentation: つくば国際会議場(茨城県)
  • Year and Date: 2011-10-28
• [Presentation] PET imaging of renal and bladder tumor with 3-[^<18>F]Fluoro-α-methyl- D-tyrosine (D-[^<18>F]FAMT) (2011)
  • Author(s): 大島康宏, 花岡宏史, 渡邉茂樹, 織内昇, 遠藤啓吾, 石岡典子
  • Organizer: 第70回日本癌学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] PETimaging of renal and bladder tumor with 3-[^<18>F]Fluoro-α-methyl-D-tyrosine(D-[^<18>F]FAMT) 3-[^<18>F]Fluoro-α-methyl-D-tyrosine(D-[^<18>F]FAMT)による腎臓がんおよひ膀胱がんのPETイメージング (2011)
  • Author(s): 大島康宏
  • Organizer: 第51回日本核医学会総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-03
• [Presentation] Development of ^<76>Br-labeled amino acid derivative for PET imaging of tumor (2010)
  • Author(s): 花岡宏史, 渡邉茂樹, 大島康宏, 織内昇, 石岡典子, 遠藤啓吾
  • Organizer: 第69回日本癌学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-24
• [Presentation] Development of ^<76>Br-labeled amino acid derivative for PET imaging of tumor (2010)
  • Author(s): Hanaoka H, et al
  • Organizer: 第69回日本癌学会学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2010-09-24