Blast-induced traumatic brain injury : Mechanism of injury and recovery by brain-machine interface
Project/Area Number |
22689039
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Cerebral neurosurgery
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥16,120,000 (Direct Cost: ¥12,400,000、Indirect Cost: ¥3,720,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2010: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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Keywords | 衝撃波工学 / レーザー工学 / 高エネルギー外傷 / 対側損傷 / 部外傷モデル / blast injury / アジ化銀 / 高速度撮影 / 頭部外傷モデル / blast wave injury |
Research Abstract |
The primary blast-induced traumatic brain injury (bTBI)phase represents the response of brain tissue to the initial blast wave. Among the four phases of bTBI, there is a remarkable paucity of information about the cause of primary bTBI. There is increasing demand to understand mechanism and pathophysiology of bTBI. Understanding the mechanism of blast propagation into skull, and the development of animal model that is validated in terms of shock wave physics and can be conducted on the bench top is a key issue to understand the mechanism, pathophysiology, and to develop proper treatment and protection for this"new" form of TBI. We have evaluated the mechanism of propagation of blast wave and shock wave in terms of visualization, pressure measurement, and numerical simulation. The experiments in brain phantom revealed that propagated wave through the skull has temporal increase of pressure on the side of wave entry and on the opposite side to the entry. The latter may explain the mechanism of contra coup injury, which is often observed in severe traumatic brain injury. The distribution of wave distribution correlated with the histological damage in animal model experiments. The results of present investigation not only has impact on understanding the mechanism of blast wave-induced traumatic brain injury, but also helps to develop brain protection methods in traumatic brain injury by high energy traffic accident, and traumatic injury by high pressure waves during natural/industrial disasters.
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Report
(3 results)
Research Products
(99 results)
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[Journal Article] Pulsed laser-induced liquid jet : evolution from shock/bubble interaction to neurosurgical application.2012
Author(s)
Nakagawa A, Kumabe T, Ogawa Y, Hirano T, Nakano T, Watanabe M, Yamamoto H, Ohtani K, Satomi S, Takayama K, Tominaga T
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Journal Title
Shock Waves
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Hypotension and hypoxia within 72 hours in traumatic brain injury patients : Retrospective analysis of prevalence and impact on hospital discharge death at Japanese tertiary referral hospital2012
Author(s)
Nakagawa A, Furuya K, Washio T, Mugikura S, Kudo D, Arafune T, Mata Mbemba D, Miyamura N, Tateno M, Sato T, Karibe H, Kushimoto S, Tominaga T
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Journal Title
Acta Neurochir (Suppl)
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Chronological analysis in Tohoku University Hospital during the first 72 hours after the Great East Japan Earthquake2012
Author(s)
Nakagawa A, Furukawa H, Kudo D, Abe Y, Sato D, Washio T, Arafune T, Arii M, Yamanouchi S, Kushimoto S, Tominaga T
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Journal Title
IEEE PULSE
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Pulsed laser-induced liquid jet : evolution from shock/bubble interaction to neurosurgical application2012
Author(s)
Nakagawa A, Kumabe T, Ogawa Y, Hirano T, Nakano T, Watanabe M, Yamamoto H, Ohtani K, Satomi S, Takayama K, Tominaga T
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Journal Title
Shock Waves
Volume: (未定)(in press)
Related Report
Peer Reviewed
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[Journal Article] Experimental application of pulsed laser-induced water jet for endoscopic submucosal dissection : mechanical investigation and preliminary experiment in swine2012
Author(s)
Sato C, Nakano T, Nakaeawa A, Yamada M, Yamamoto H, Kamei T, Miyata G, Sato A, Fujishima F, Nakai M, Niinomi M, Takayama K, Tominaga T, Satomi S
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Journal Title
Digestive Endoscopy
Volume: (未定)(in press)
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Peer Reviewed
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[Journal Article] Chronological analysis in Tohoku University Hospital during the first 72 hours after the Great East Japan Earthquake2012
Author(s)
Nakagawa A, Furukawa H, Kudo D, Abe Y, Sato D, Washio T, Arafune T, Arii M, Yamanouchi S, Kushimoto S, Tominaga T
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Journal Title
IEEE Pulse
Volume: (未定)(in press)
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Peer Reviewed
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[Journal Article] Experimental application of pulsed laser-induced liquid jet (LILJ) technology for esophagogastrointestinal endoscopic treatment2012
Author(s)
Nakano T, Yamada M, Nakagawa A, Yamamoto H, Nakagawa A, Yamamoto H, Nakai M, Miyata G, Miyazaki S, Sato A, Takayama K, Tominaga T, Satomi S
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Journal Title
Proceedings of BMPE
Volume: (未定)(in press)
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[Journal Article] Preliminary experiment for neuroendoscopic application of pulsed Ho : YAG laser-induced liquid jet2012
Author(s)
Nakagawa A, Nakano T, Ogawa Y, Yamamoto H, Sato C, Yamada M, Nakai M, Sun M, Miyata G, Niinomi M, Takayama K, Satomi S, Tominaga T
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Journal Title
Proceedings of BMPE
Volume: (未定)(in press)
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[Journal Article] Pulsed laser-induced liquid jet : evolution from shock/bubble interaction to neurosurgical application.2011
Author(s)
Nakagawa A, Kumabe T, Ogawa Y, Hirano T, Nakano T, Watanabe M, Yamamoto H, Ohtani K, Satomi S, Takayama K, Tominaga T.
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Journal Title
Shock Waves
Volume: (未定 in press)
Related Report
Peer Reviewed
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[Journal Article] Experimental application of pulsed laser-induced liquid jet (LILJ) technology for esophagogastrointestinal endoscopic treatment.2011
Author(s)
Nakano T, Yamada M, Nakagawa A, Yamamoto H, Nakai M, Miyata G, Miyazaki S, Sato A, Takayama K, Tominaga T, Satomi S.
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Journal Title
Proceedings of BMPE
Volume: (未定 in press)
Related Report
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[Journal Article] reliminary experiment for neuroendoscopic application of pulsed Ho : YAG laser-induced liquid jet.2011
Author(s)
Nakagawa A, Nakano T, Ogawa Y, Yamamoto H, Sato C, Yamada M, Nakai M, Sun M, Miyata G, Niinomi M, Takayama K, Satomi S, Tominaga T.
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Journal Title
Proceedings of BMPE
Volume: (未定 in press)
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[Presentation] 重症頭部外傷の管理2012
Author(s)
中川敦寛
Organizer
第35回日本脳神経外傷学会脳神経外科教育セミナー
Place of Presentation
学術総合センター東京
Year and Date
2012-03-10
Related Report
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[Presentation] Hypotension and hypoxia within 72 hours in traumatic brain injury patients : Retrospective analysis of prevalence and impact on hospital discharge death at Japanese tertiary referral hospital.2011
Author(s)
Nakagawa A, Furuya K, Washio T, Mugikura S, Kudo D, Tatsuhiko A, Mata Mbemba Daddy, Miyamura N, Tateno M, Sato T, Karibe H, Kushimoto S, Tominaga T
Organizer
XV International Conference on Brain Edema and Cellular Injury
Place of Presentation
Tokyo
Year and Date
2011-11-24
Related Report
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[Presentation] Hypotension and hypoxia within 72 hours in traumatic brain injury patients : Retrospective analysis of prevalence and impact on hospital discharge death at Japanese tertiary referral hospital2011
Author(s)
Nakagawa A, Furuya K, Washio T, Mugikura S, Kudo D, Tatsuhiko A, Mata Mbemba Daddy, Miyamura N, Tateno M, Sato T, Karibe H, Kushimoto S, Tominaga T
Organizer
XV International Conference on Brain Edema and Cellular Injury
Place of Presentation
Nichidai Kaikan, Tokyo
Year and Date
2011-11-24
Related Report
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[Presentation] Clues to deal with "unexpected" disaster and huge mismatching during the first 72 hours : Lessons from the chronologies2011
Author(s)
Nakagawa A, Furukawa H, Abe Y, Kudo D, Endo T, Yamanouchi S, Kushimoto S, Tominaga T
Organizer
在ボストン日本領事館東北大学中川医師、Masschusetts医師会、在ボストン災害識者を交えての総領事主催懇談会
Place of Presentation
在ボストン日本総領事館,Boston, MA, United States(講演招待)
Year and Date
2011-09-01
Related Report
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[Presentation] Clinical microsurgical experience and experimental endoscopic application of pulsed Ho : YAG laser-induced liquid jet2011
Author(s)
Nakagawa A, Nakano T Ogawa Y, Yamamoto H, Sato C, Yamada M, Nakai M, Sun M, Miyata G, Niinomi M, Takayama K, Satomi M, Tominaga T
Organizer
50 th aanual conference of Japanese annual conference of Japanse society of Biogical engineering
Place of Presentation
東京電機大学
Year and Date
2011-05-01
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