Virotherapy for bone and soft tissue sarcoma by telomerase-specific oncolytic adenovirus
| Project/Area Number |
22689040
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Keywords | 骨 / 軟部腫瘍学 / 軟部肉腫 / ウイルス療法 / アデノウイルス / テロメラーゼ / 骨肉腫 |
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| Research Abstract |
Bone and soft tissue sarcoma cells treated by telomerase-specific oncolytic adenovirus showed a dose- and time-dependent viral replication and cytolysis, which were positively associated with the expression levels of coxackie-adenoviral receptor and hTERT. Oncolytic adenoviral infection also induced both apototic and autophagic cell death in these cells, and also showed inhibition of tumor growth in osteosarcoma xenograft mouse model.
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Report
(4 results)
Research Products
(9 results)
