| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Research Abstract |
The glaucoma is an eye disease that is the primary cause of vision loss in Japan, and its prevalence rate is still increasing. Although high intraocular pressure was an important risk-factor in glaucoma, in this research, the clinical validity of the ocular fundus blood flow evaluation in glaucoma diagnosis, participation of the oxidant stress defense mechanism and calpain to control of mouse retinal ganglion cell death, and mouse retinal ganglion cell protection ability of antioxidants and calpain inhibitor were newly clarified. These results will be important for pathological elucidation, an early detection, and development of nerve protection treatments in the field of glaucoma.
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