Development of an integrated neuroprotective treatments in glaucoma
| Project/Area Number |
22689045
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Tohoku University |
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Principal Investigator |
NAKAZAWA Toru 東北大学, 大学院・医学系研究科, 教授 (30361075)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2010: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Keywords | 緑内障 / 視神経乳頭循環不全 / 乳頭陥凹拡大 / 軸索流障害 / カルパインインヒビター / Laser Speckle Flowgraphy / 酸化ストレス / Nrf2 / カルバイン インヒビター |
|---|
| Research Abstract |
The glaucoma is an eye disease that is the primary cause of vision loss in Japan, and its prevalence rate is still increasing. Although high intraocular pressure was an important risk-factor in glaucoma, in this research, the clinical validity of the ocular fundus blood flow evaluation in glaucoma diagnosis, participation of the oxidant stress defense mechanism and calpain to control of mouse retinal ganglion cell death, and mouse retinal ganglion cell protection ability of antioxidants and calpain inhibitor were newly clarified. These results will be important for pathological elucidation, an early detection, and development of nerve protection treatments in the field of glaucoma.
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Report
(3 results)
Research Products
(58 results)
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[Journal Article] The critical role of calpain in axonal damage-induced retinal ganglion cell death2011
Author(s)
Ryu M, Yasuda M, Shi D, Shanab AY, Watanabe R, Himori N, Omodaka K, Yokoyama Y, Takano J, Saido T, Nakazawa T
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Journal Title
J Neurosci Res
Volume: 5
Pages: 1721-7
Related Report
Peer Reviewed
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[Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid)nanoparticles containing dexamethasone2011
Author(s)
Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K
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Journal Title
J Control Release
Volume: 151
Pages: 65-73
Related Report
Peer Reviewed
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