Technology creation of iPS cell-based alveolar bone regenerationusing the gingiva as a cell source
Project/Area Number |
22689049
|
Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Single-year Grants |
Research Field |
Prosthetic dentistry
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Research Institution | Osaka University |
Principal Investigator |
EGUSA Hiroshi 大阪大学, 大学院・歯学研究科, 助教 (30379078)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥22,360,000 (Direct Cost: ¥17,200,000、Indirect Cost: ¥5,160,000)
Fiscal Year 2012: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2011: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2010: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
|
Keywords | iPS細胞 / 歯肉 / 再生歯科医療 / 骨組織再生 / 口腔粘膜 / 細胞移植 / 歯槽堤再建 |
Research Abstract |
iPS cells can be generated from somatic cells by forced expression of defined exogenous factors. We found that the gingiva, which is often resected during general dental treatments and treated as biomedical waste, is a promising source of iPS cells. These iPS cells were capable of osteogenic differentiation, which could be greatly enhanced by some small molecules. The generation of iPS cells from the gingiva offers a promising method for the facile production of iPS cells by dentists, which represent an important step toward the development of novel alveolar bone regeneration technology.
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Report
(4 results)
Research Products
(150 results)
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[Presentation] Comparative analysis of iPSCs and MSCs during osteogenic differentiation
Author(s)
Uraguchi S, Egusa H, Kayashima H, Wang F, Yu G, Okawa H, Yamamoto H, Fukuyasu S, Akashi Y, Yatani H
Organizer
91th IADR General Session
Place of Presentation
Seattle, USA
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