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Functional data analysis for medical data and its application

Research Project

Project/Area Number 22700298
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Statistical science
Research InstitutionKurume University

Principal Investigator

ARAKI Yuko  久留米大学, バイオ統計センター, 助教 (80403913)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords医薬生物 / ゲノム統計解析 / 関数化データ解析 / 関数データ解析 / 情報量基準 / 高次元医学データ / 基底展開法 / 正則化法 / 変数選択 / スパース性 / 高次元データ / 情報量規準 / 判別モデル / 統計的モデリング / 生物統計 / 次元縮小 / モデル選択 / 判別
Research Abstract

To extract valuable information from medical data which has a lots of observational points result in high dimensional data with complex structure, we developed statistical methods and applied them to the analysis of medical data. We proposed functional data analytic approach for dimension reduction of high dimensional data such as medical imaging data, brain waves or shape data. We further proposed classification model for high dimensional data and its evaluation methods. We also developed an efficient nonlinear model selection method based on information criterion. The proposed methods were applied to life science problems.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (39 results)

All 2013 2012 2011 2010 Other

All Journal Article (17 results) (of which Peer Reviewed: 11 results) Presentation (19 results) (of which Invited: 1 results) Book (2 results) Remarks (1 results)

  • [Journal Article] Regularized logistic discrimination with basis expansions for the early detection of Alzheimer's disease based on three-dimensional MRI data.2013

    • Author(s)
      Araki,Y., Kawaguchi,A., Yamashita,F.
    • Journal Title

      Advances in Data Analysis and Classification

      Volume: 7 Issue: 1 Pages: 109-119

    • DOI

      10.1007/s11634-013-0127-5

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient regularization parameter selection via information criteria2013

    • Author(s)
      Araki,Y.
    • Journal Title

      Communications in Statistics - Simulation and Computation-

      Volume: 42 Issue: 2 Pages: 280-293

    • DOI

      10.1080/03610918.2011.639969

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 高次元脳画像解析のための二段階正則化関数判別モデル.2012

    • Author(s)
      荒木由布子,川口淳.
    • Journal Title

      応用統計学会年会講演予稿集

      Pages: 33-38

    • Related Report
      2012 Final Research Report
  • [Journal Article] 高次元脳画像解析のための二段階正則化関数判別モデル2012

    • Author(s)
      荒木由布子
    • Journal Title

      応用統計学会2012年度年会講演予稿集

      Volume: なし Pages: 33-38

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Efficient regularization parameter selection via information criteria2012

    • Author(s)
      Yuko Araki
    • Journal Title

      Communication in statistics, simulation and computation

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 低置胎盤の術中出血量に影響を及ぼす因子についての検討.2011

    • Author(s)
      蔵本昭孝,堀大蔵,井上茂,堀之内崇士,品川貴章,上妻友隆,下村卓也,河田高伸,林龍之介,嘉村敏治,山下拓人,荒木由布子,角間辰之.
    • Journal Title

      日本周産期・新生児医学会雑誌

      Volume: 47(4) Pages: 873-877

    • NAID

      10030287754

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 関 数データ解析の 3 次元脳画像解析へ の応用2011

    • Author(s)
      川口淳, 荒木由 布子 , 山下典夫.
    • Journal Title

      日本計算機統計学会第25回 講演論文集

      Pages: 85-88

    • Related Report
      2012 Final Research Report
  • [Journal Article] 山下典夫.3次元脳画像によるアルツハイマー病早期発見のための関数データ解析.2011

    • Author(s)
      荒木由布子,川口淳
    • Journal Title

      応用統計学会年会講演予稿集

      Pages: 67-72

    • Related Report
      2012 Final Research Report
  • [Journal Article] Prefrontal brain function in children with anorexia nervosa: A near-infrared spectroscopy study.2011

    • Author(s)
      Nagamitsu S, Araki Y., et al.
    • Journal Title

      Brain & Development

      Volume: 33 Issue: 1 Pages: 35-44

    • DOI

      10.1016/j.braindev.2009.12.010

    • NAID

      10029560112

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 三次元脳画像によるアルツハイマー病早期発見のための関数データ解析2011

    • Author(s)
      荒木由布子
    • Journal Title

      応用統計学会2011年度年会講演予稿集

      Pages: 67-72

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 低置胎盤の術中出血量に影響を及ぼす因子についての検討2011

    • Author(s)
      蔵本昭孝
    • Journal Title

      日本周産期・新生児医学会雑誌

      Volume: 47(4) Pages: 873-877

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prefrontal brain function in children with anorexia nervosa : A near-infrared spectroscopy study2011

    • Author(s)
      Nagamitsu S.
    • Journal Title

      Brain & Development

      Volume: 33 Pages: 35-44

    • Related Report
      2011 Annual Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 関数データ解析の三次元脳画像解析への応用2011

    • Author(s)
      川口淳
    • Journal Title

      日本計算機統計学会第25回大会講演論文集

      Pages: 85-88

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Characteristic prefrontal blood volume patterns when imaging bodytype, high-calorie food, and mother-child attachment in childhood anorexia nervosa: A near infrared spectroscopy study.2010

    • Author(s)
      Nagamitsu S, Yamasita F, Araki Y., et al.
    • Journal Title

      Brain & Development

      Volume: 32 Issue: 2 Pages: 162-167

    • DOI

      10.1016/j.braindev.2009.01.002

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of the strngths and difficulties questionnaire scores between children withhigh-functioning autism apectrum disorder(HFASD) andattention-deficit/hyperactivity disorder(AD/HD).2010

    • Author(s)
      Iizuka C, Yamashita Y, Nagamitsu S, Yamashita T, Araki Y, Ohya T, Hara M, Shibuya I, Kakuma T, Matsuishi T.
    • Journal Title

      Brain & Development

      Volume: 32 Pages: 609-612

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regularized functional classification of the kinetic trace of developmental mouse retina2010

    • Author(s)
      Yuko Araki
    • Journal Title

      Proceedings of Australian Statistical Conference 2010

      Volume: 2010 Pages: 55-55

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characteristic prefrontal blood volume patterns when imaging body type, high-calorie food, and mother-child attachment in childhood anorexia nervosa : A near infrared spectroscopy study2010

    • Author(s)
      Nagamitsu S.
    • Journal Title

      Brain & Development

      Volume: 32 Pages: 162-167

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 二段階正則化に基づく生存時間解析法と脳画像データへの適用2012

    • Author(s)
      荒木由布子
    • Organizer
      2012年度統計関連学会連合大会
    • Place of Presentation
      北海道大学
    • Year and Date
      2012-09-11
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] Two-Way RegularizedFunctional Classification for HighDimensional Brain MRI Data.2012

    • Author(s)
      Araki Y
    • Organizer
      26th International Biometric Conference
    • Place of Presentation
      Kobe International Conference Center.
    • Year and Date
      2012-08-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 正則化関数データモデリングとその適用.2012

    • Author(s)
      荒木由布子.
    • Organizer
      第7回BiostatisticsNetwork
    • Place of Presentation
      統計数理研究所
    • Year and Date
      2012-08-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 高次元脳画像解析のための二段階正則化関数判別モデル.2012

    • Author(s)
      荒木由布子
    • Organizer
      応用統計学会2012年度年会
    • Place of Presentation
      統計数理研究所
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] The analysis ofhigh-dimensional brain image via sparse principal componentfunctional regression.2012

    • Author(s)
      Araki,Y.
    • Organizer
      East Asia Regional Biometric Conference 2012.
    • Place of Presentation
      Seoul National University, Seoul, Korea.
    • Related Report
      2012 Final Research Report
  • [Presentation] The analysis of high-dimensional brain image via sparse principal component functional regression2012

    • Author(s)
      Yuko Araki
    • Organizer
      East Asia Regional Biometric Conference 2012
    • Place of Presentation
      ソウル大学,ソウル,韓国
    • Related Report
      2011 Annual Research Report
  • [Presentation] The early detection of Alzheimer's diseases based on MRI data via sparse functional logistic classification.2011

    • Author(s)
      Araki,Y.
    • Organizer
      Joint Meeting of the 2011 Taipei International Statistical Symposium and 7th Conference of the Asian Regional Section of the IASC.
    • Place of Presentation
      AcademiaSinica, Taipei, Taiwan.
    • Related Report
      2012 Final Research Report
  • [Presentation] 認知症早期発見のための三次元脳画像に基づく関数データ解析2011

    • Author(s)
      荒木由布子.
    • Organizer
      2011年度統計関連学会連合大会
    • Place of Presentation
      九州大学伊都キャンパス.
    • Related Report
      2012 Final Research Report
  • [Presentation] 三次元脳画像によるアルツハイマー病早期発見のための関数データ解析2011

    • Author(s)
      荒木由布子.
    • Organizer
      応用統計学会2011年度年会
    • Place of Presentation
      大阪大学吹田キャンパス銀杏会館ホール.
    • Related Report
      2012 Final Research Report
  • [Presentation] 関数データ解析の三次元脳画像解析への応用.2011

    • Author(s)
      川口淳.
    • Organizer
      日本計算機統計学会第25回大会
    • Place of Presentation
      函館市亀田福祉センター.
    • Related Report
      2012 Final Research Report
  • [Presentation] The early detection of Alzheimer's diseases based on MRI data via sparse functional logistic classification2011

    • Author(s)
      Yuko Araki
    • Organizer
      Joint meeting of the 2011 Taipei International Statistical Symposium
    • Place of Presentation
      Academia Sinica,台北,台湾
    • Related Report
      2011 Annual Research Report
  • [Presentation] 認知症早期発見のための3次元脳画像に基づく関数データ解析2011

    • Author(s)
      荒木由布子
    • Organizer
      2011年度統計関連学会連合大会
    • Place of Presentation
      九州大学,福岡
    • Related Report
      2011 Annual Research Report
  • [Presentation] 三次元脳画像によるアルツハイマー病早期発見のための関数データ解析2011

    • Author(s)
      荒木由布子
    • Organizer
      応用統計学会2011年度年会
    • Place of Presentation
      大阪大学,大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] 関数データ解析の3次元脳画像解析への応用2011

    • Author(s)
      川口淳
    • Organizer
      日本計算機統計学会第25回大会
    • Place of Presentation
      函館市亀田福祉センター,函館,北海道
    • Related Report
      2011 Annual Research Report
  • [Presentation] Regularized functional classification of the kinetic trace of developmental mouse retina2010

    • Author(s)
      Yuko Araki
    • Organizer
      Australian Statistical Conference 2010
    • Place of Presentation
      パース,オーストラリア
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Regularized functional classification of the kinetic trace of developmental mouse retina.2010

    • Author(s)
      Araki, Y.
    • Organizer
      The 20th Australian Statistical Conference
    • Place of Presentation
      Fremantle, Australia.
    • Related Report
      2012 Final Research Report
  • [Presentation] Two-Way Regularized Functional Classification for High Dimensional Brain MRI Data

    • Author(s)
      Araki, Y.
    • Organizer
      26th International Biometric Conference
    • Place of Presentation
      Kobe International Conference Center
    • Related Report
      2012 Annual Research Report
  • [Presentation] 正則化関数データモデリングとその適用

    • Author(s)
      荒木由布子
    • Organizer
      第7回Biostatistics Network
    • Place of Presentation
      統計数理研究所
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 高次元脳画像解析のための二段階正則化関数判別モデル

    • Author(s)
      荒木由布子
    • Organizer
      応用統計学会2012年度年会
    • Place of Presentation
      統計数理研究所
    • Related Report
      2012 Annual Research Report
  • [Book] バイオ統計の基礎2010

    • Author(s)
      柳川堯,荒木由布子
    • Publisher
      近代科学社
    • Related Report
      2012 Final Research Report
  • [Book] バイオ統計の基礎2010

    • Author(s)
      柳川尭
    • Publisher
      近代科学社
    • Related Report
      2010 Annual Research Report
  • [Remarks] 久留米大学バイオ統計センター WEBSITE

    • URL

      http://www.med.kurume-u.ac.jp/med/biostat/staff/araki/index.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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