Development and use of scan statistics for community diagnosis with considering regional differences in spatial epidemiology

• Project/Area Number: 22700301
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Statistical science
• Research Institution: National Institute of Public Health
• Principal Investigator: TAKAHASHI Kunihiko 国立保健医療科学院, 政策技術評価研究部, 主任研究官 (50323259)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 空間・環境統計 / 空間疫学 / 地域診断 / スキャン統計量 / 空間統計学 / 疾病集積性 / ベイズ推定 / 疾病地図

Research Abstract

We proposed several scan statistics for detecting disease clusters and Bayesian approach to indices of regional healthcare expenditure in Japan for spatial epidemiology and community diagnosis, with taking account of regional differences which are caused by population size of each area. Our simulation studies could show that the proposed methods can accurately detect the clusters and stably estimate the level of regional medical expenses in compared with conventional methods.

Research Products

• [Journal Article] A flexible spatial scan statistic with a restricted likelihood ratio for detecting disease clusters (2012)
  • Author(s): Tango T, Takahashi K
  • Journal Title: Statistics in Medicine Volume: (印刷中)
• [Journal Article] A scan statistic to extract causal gene clusters from case-control genome-wide rare CNV data (2011)
  • Author(s): Nishiyama T, Takahashi K, Tango T, Pinto D, Scherer SW, Takami S, Kishino H
  • Journal Title: BMC Bioinformatics Volume: 12 Pages: 205-205
• [Journal Article] A space-time scan statistic for detecting emerging outbreaks (2011)
  • Author(s): Tango T, Takahashi K, Kohriyama K
  • Journal Title: Biometrics Volume: 67 Pages: 106-115
• [Journal Article] A scan statistic to extract causal gene clusters fromcase-control genome-wide rare CNV data (2011)
  • Author(s): Nishiyama, T., Takahashi, K., Tango, T., Pinto, D., Scherer, S. W., Takami, S., and Kishino, H
  • Journal Title: BMC Bioinformatics Volume: 12 Issue: 1 Pages: 205-205
  • DOI: 10.1186/1471-2105-12-205
  • Peer Reviewed
• [Journal Article] Temporal trends and geographic clusters of mortality from amyotrophic lateral sclerosis in Japan, 1995-2004 (2010)
  • Author(s): Doi Y, Yokoyama T, Tango T, Takahashi K, Fujimoto K, Nakano I
  • Journal Title: Journal of the Neurological Sciences Volume: 298 Pages: 78-84
• [Journal Article] A space-time scan statistic for detecting emerging outbreak (2010)
  • Author(s): Tango T
  • Journal Title: Biometrics Volume: 67 Pages: 106-115
  • Peer Reviewed
• [Journal Article] Temporal trends and geographic clusters of mortality amyotrophic lateral sclerosis in Japan, 1995-2004 (2010)
  • Author(s): Doi Y
  • Journal Title: Journal of the Neurological Sciences Volume: 298 Pages: 78-84
  • Peer Reviewed
• [Journal Article] Assignment of grouped exposure levels for trend estimation in a regression analysis of summarized data (2010)
  • Author(s): Takahashi K
  • Journal Title: Statistics in Medicine Volume: 29 Pages: 2605-2616
  • Peer Reviewed
• [Presentation] 特定疾患(難病)医療受給者証所持者数の地域比較 (2012)
  • Author(s): 高橋邦彦,横山徹爾,金谷泰宏,土井由利子
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 東京都
  • Year and Date: 2012-01-28
• [Presentation] 特定疾患(難病)医療受給者証所持者数の地域比較学 (2012)
  • Author(s): 高橋邦彦, 横山徹爾, 他
  • Organizer: 第22回日本疫学会学術総会
  • Place of Presentation: 学術総合センター(東京都)
  • Year and Date: 2012-01-28
• [Presentation] わが国における年間の心肺停止傷病者救急搬送件数の時間的集積性の検出 (2011)
  • Author(s): 高橋邦彦, 武村真治, 他
  • Organizer: 第70回日本公衆衛生学会総会
  • Place of Presentation: 秋田市
  • Year and Date: 2011-10-20
• [Presentation] FleXScanによる疾病集積性の検出～特定疾患(難病)の地域比較への適用～ (2011)
  • Author(s): 高橋邦彦,土井由利子,横山徹爾,金谷泰宏
  • Organizer: 2011年度統計関連学会連合大会企画セッション「医学データの分類と判別」
  • Place of Presentation: 九州大学
  • Year and Date: 2011-09-06
• [Presentation] FleXScanによる疾病集積性の検出～特定疾患(難病)の地域比較への適用～ (2011)
  • Author(s): 高橋邦彦, 土井由利子, 他
  • Organizer: 11年度統計関連学会連合大会
  • Place of Presentation: 九州大学(企画セッション招待講演)
  • Year and Date: 2011-09-06
• [Presentation] 区間データを用いた回帰分析における曝露量の定め方 (2011)
  • Author(s): 高橋邦彦
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2011-01-21
• [Presentation] FleXScan with a restricted likelihood ratio : a spatial scan statistic for irregularly shaped clusters (2011)
  • Author(s): Tango T, Takahashi K.
  • Organizer: 32nd Annual Conference of the International Society for Clinical Biostatistics
  • Place of Presentation: Ottawa, Canada
• [Presentation] On a flexible scan statistic with a restricted likelihood ratio (2011)
  • Author(s): 丹後俊郎,高橋邦彦
  • Organizer: 2011年度日本計量生物学会年会
  • Place of Presentation: 大阪大学
• [Presentation] スキャン統計量を用いた遺伝子パスウェイに基づくゲノムワイドCopy Number Variation(CNV)データ解析法の開発 (2011)
  • Author(s): 西山毅,高橋邦彦,丹後俊郎,高見聖,岸野洋久
  • Organizer: 第21回日本疫学会学術総会
  • Place of Presentation: 北海道札幌市
• [Presentation] A maximum scan score-type statistic based on Anscombe's variance stabilization transformation for disease clustering (2010)
  • Author(s): Takahashi K
  • Organizer: XXVth International Biometric Conference
  • Place of Presentation: Florianoplis, Brazi
  • Year and Date: 2010-12-10
• [Presentation] A maximum scan score-type statistic based on Anscombe's variance stabilization transformation for disease clustering (2010)
  • Author(s): Takahashi K, Tango T.
  • Organizer: XXVth International Biometric Conference
  • Place of Presentation: Florianoplis, Brazil
• [Presentation] 隣接地域の影響を考慮した医療費地域差指数のベイズ推定 (2010)
  • Author(s): 高橋邦彦,飛田英祐,山岡和枝,丹後俊郎
  • Organizer: 第69回日本公衆衛生学会総会
  • Place of Presentation: 東京国際フォーラム
• [Book] 疾病地図 (2011)
  • Author(s): 高橋邦彦
  • Publisher: 丸善
• [Book] 統計応用の百科事典 (2011)
  • Author(s): 松原望, 美添泰人, 他(編)
  • Publisher: 丸善出版
• [Book] 空間スキャン統計量 (2010)
  • Author(s): 高橋邦彦
  • Publisher: 朝倉書店
• [Book] 症候サーベイランス (2010)
  • Author(s): 高橋邦彦
  • Publisher: 朝倉書店
• [Book] 医学統計学の事典 (2010)
  • Author(s): 丹後俊郎
  • Publisher: 朝倉書店