Analysis of information processing mechanisms of insulin temporal patterns

• Project/Area Number: 22700310
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Bioinformatics/Life informatics
• Research Institution: The University of Tokyo
• Principal Investigator: KUBOTA Hiroyuki 東京大学, 大学院・理学系研究科, 助教 (40376603)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: システムズバイオロジー / インスリン / シグナル伝達 / 時間情報コーディング

Research Abstract

Blood insulin exhibits several temporal patterns. It is reported that the temporal patterns of insulin are important for regulation of metabolic functions. However, how insulin selectively regulates multiple metabolic functions remains unknown. We demonstrate that the AKT pathway can multiplex distinct patterns of insulin and the downstream molecules selectively decode the temporal patterns of insulin usingexperiments and simulation.

Research Products

• [Journal Article] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway (2012)
  • Author(s): Hiroyuki Kubota, Rei Noguchi, Yu Toyoshima, Yu-ichi Ozaki, Shinsuke Uda, Kanako Watanabe, Wataru Ogawa and Shinya Kuroda
  • Journal Title: Molecular Cell Volume: 46(6) Issue: 6 Pages: 820-832
  • DOI: 10.1016/j.molcel.2012.04.018
  • Peer Reviewed
• [Journal Article] AKT経路の情報多重化によるインスリン作用の時間情報コーディング (2012)
  • Author(s): 久保田浩行、黒田真也
  • Journal Title: 実験医学 Volume: 30巻 Pages: 2609-2612
• [Journal Article] AKT経路の情報多重化によるインスリン作用の時間情報コーディング (2012)
  • Author(s): 久保田浩行、黒田真也
  • Journal Title: 新着論文レビュー
  • URL: http://first.lifesciencedb.jp/archives/5054
• [Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway (2012)
  • Author(s): 久保田浩行
  • Organizer: JSDB&JSCB2012、
  • Place of Presentation: 神戸国際会議場
• [Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT pathway (2012)
  • Author(s): 久保田浩行
  • Organizer: Joint meeting of JSDB 45th & JSCB 64th
  • Place of Presentation: 神戸・神戸国際会議場
• [Presentation] AKT経路の情報多重化によるインスリン作用の時間情報コード (2011)
  • Author(s): 久保田浩行
  • Organizer: BMB2011
  • Place of Presentation: パシフィ コ横浜
• [Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway (2011)
  • Author(s): iroyuki Kubota
  • Organizer: ICSB2011
  • Place of Presentation: Heidelberg, Germany
• [Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT pathway (2011)
  • Author(s): 久保田浩行
  • Organizer: MBSJ 2011
  • Place of Presentation: 横浜・パシフィコ横浜
• [Presentation] Temporal Coding of Insulin Action through Multiplexing of the AKT pathway (2011)
  • Author(s): 久保田浩行
  • Organizer: ICSB2011
  • Place of Presentation: ドイツ・ハイデルベルグ
• [Presentation] インスリンシグナル伝達経路の時系列解析 (2010)
  • Author(s): 久保田浩行
  • Organizer: 日本分子生物学会年会
  • Place of Presentation: 神戸ポートアイランド
  • Year and Date: 2010-12-10
• [Presentation] インスリン作用のAKT経路による多重情報コード (2010)
  • Author(s): 久保田浩行
  • Organizer: BMB2010
  • Place of Presentation: 神戸ポートアイランド
• [Remarks]
  • URL: http://kurodalab.bi.s.u-tokyo.ac.jp/ja/index.html
• [Remarks]
  • URL: http://www.u-tokyo.ac.jp/ja/todai-research/research-information/temporal-coding-of-insulin-action-through-multiplexing-of-the-akt-pathway/