Analysis of Protein-protein interactions and development of protein-protein docking method

• Project/Area Number: 22700314
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Bioinformatics/Life informatics
• Research Institution: Kitasato University
• Principal Investigator: TERASHI Genki 北里大学, 薬学部, 講師 (40383658)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 生体生命情報学 / バイオインフォマティクス / タンパク質間相互作用

Research Abstract

In order to analyzethe protein-protein interactions(PPIs) and new docking method, we have developed the PPIsdatabasewhich consists the three dimensionalcoordinates of interactingsitesand a new fast structure based search algorithm.

Research Products

• [Journal Article] A Protein Three-Dimensional Substructure Search Program Based on the Lower Bound of a Root Mean Square Deviation Value (2012)
  • Author(s): Terashi G, Shibuya T, Takeda-Shitaka M
  • Journal Title: Journal of computational biology Volume: 19(5) Issue: 5 Pages: 493-503
  • DOI: 10.1089/cmb.2011.0230
  • URL: http://online.liebertpub.com/doi/abs/10.1089/cmb.2011.0230
  • Peer Reviewed
• [Presentation] LB3D : Fast protein 3D substructure search program (2011)
  • Author(s): 寺師玄記
  • Organizer: 2011年日本バイオインフォマティクス学会年会
  • Place of Presentation: 神戸
  • Year and Date: 2011-12-08
• [Presentation] LB3D : Fast protein 3D substructure search program (2011)
  • Author(s): 寺師玄記
  • Organizer: 日本バイオインフォマティクス学会2011年会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2011-11-08
• [Presentation] タンパク質間相互作用予測プログラムの開発と応用 (2010)
  • Author(s): 寺師玄記
  • Organizer: 第23回北里バイオサイエンスフォーラム
  • Place of Presentation: 青森県十和田
  • Year and Date: 2010-08-06