Analysis of intrinsically disordered proteins based on molecular evolution
| Project/Area Number |
22700318
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | National Institute of Advanced Industrial Science and Technology |
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Principal Investigator |
HIROSE Shuichi 独立行政法人産業技術総合研究所, 生命情報工学研究センター, 協力研究員 (60549898)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 分子進化 / 遺伝子進化 / 天然変性タンパク質 / バイオインフォマティクス / 進化系統樹 |
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| Research Abstract |
In order to find out distinctive features of intrinsically disordered proteins and means for classification of them, we conducted the bioinformatics analysis based on molecular evolution. As a result, two features, which are "ortholog distribution pattern in phylogenetic tree" and "change of disordered region proportion", were identified as features. Additionally, it was indicated that intrinsically disordered proteins can be classified based on the two features. Moreover, new knowledge concerning relationship between increase in disordered region and protein function acquisition was obtained.
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Report
(3 results)
Research Products
(4 results)
